GPRASP1 and OPRK1

Number of citations: 0 (PubMedID 15086532)
Data Source: BioGRID (pull down)

		GPRASP1	OPRK1
Name		G protein-coupled receptor associated sorting protein 1	opioid receptor kappa 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Mitochondrion Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum T-tubule Dendrite Synaptic Vesicle Membrane Sarcolemma Presynaptic Membrane Neuron Projection Neuronal Cell Body Perikaryon Axon Terminus Postsynaptic Membrane
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Receptor Serine/threonine Kinase Binding Dynorphin Receptor Activity Neuropeptide Binding
	Biological Process	Endosome To Lysosome Transport G Protein-coupled Receptor Catabolic Process	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Sensory Perception Locomotory Behavior Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Insulin Positive Regulation Of Dopamine Secretion Negative Regulation Of Luteinizing Hormone Secretion Response To Nicotine G Protein-coupled Opioid Receptor Signaling Pathway Response To Cocaine Maternal Behavior Eating Behavior Response To Estrogen Estrous Cycle Response To Ethanol Regulation Of Saliva Secretion Behavioral Response To Cocaine Sensory Perception Of Temperature Stimulus Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Glucose Stimulus Positive Regulation Of P38MAPK Cascade Positive Regulation Of Potassium Ion Transmembrane Transport Response To Acrylamide Positive Regulation Of Eating Behavior Conditioned Place Preference
Pathways		None	Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates neuronal receptors and channels
Drugs		None	Tramadol Atomoxetine Morphine Codeine Amitriptyline Hydromorphone Mirtazapine Progesterone Meperidine Oxycodone Dextromethorphan Lamotrigine Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Fentanyl Levomenthol Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Naloxone Dezocine Ketamine Aripiprazole 3-Methylthiofentanyl Diamorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Asimadoline CR665 ADL 10-0101 Mianserin Tapentadol Nalmefene Alvimopan Amisulpride Morphine glucuronide Ketobemidone Methylnaltrexone Butyrfentanyl Pholcodine Eluxadoline Opium Pentoxyverine Naldemedine Difelikefalin Samidorphan Loxicodegol
GWAS		No GWAS studies recorded	Age at first sexual intercourse ( 34211149 ) Body size at age 10 ( 32376654 ) IgE levels in asthmatics (D.p. specific) ( 23967269 ) Modic changes ( 30808802 ) Systolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373 )
Interacting Genes		48 interacting genes: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 DSCAM F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1	6 interacting genes: GABARAPL1 GNA15 GPRASP1 NHERF1 NKG7 OPRD1
Entrez ID		9737	4986
HPRD ID		02333	01309
Ensembl ID		ENSG00000198932	ENSG00000082556
Uniprot IDs		Q5JY77	A0A5F9ZI09 P41145
PDB IDs		Not available	4DJH 6B73 6VI4 7T10 7T11 7UL2 7UL3 7UL5 7Y1F 7YIT 7YMJ 8DZP 8DZQ 8DZR 8DZS 8F7W 8FEG 8HNN 8K2W 8VVE 8VVF 8VVG 9D61
GO Terms Enriched among Interactors		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G Protein-coupled Acetylcholine Receptor Activity Regulation Of Blood Pressure Signal Transduction Regulation Of Smooth Muscle Contraction Trans-synaptic Signaling System Process Synaptic Signaling G Protein-coupled Peptide Receptor Activity Regulation Of System Process G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Chemical Synaptic Transmission Vascular Process In Circulatory System Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Blood Pressure Dendrite Blood Vessel Diameter Maintenance Regulation Of Tube Size Circulatory System Process G Protein-coupled Opioid Receptor Activity Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Postsynaptic Signal Transduction Positive Regulation Of Muscle Contraction Plasma Membrane G Protein-coupled Opioid Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Smooth Muscle Contraction Signaling Regulation Of Biological Quality Positive Regulation Of Flagellated Sperm Motility Tachykinin Receptor Activity Cell Communication Regulation Of Muscle Contraction Positive Regulation Of Cilium Movement Regulation Of Blood Circulation Regulation Of Flagellated Sperm Motility Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Muscle System Process Positive Regulation Of MAPK Cascade	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target G Protein-coupled Enkephalin Receptor Activity Renal Phosphate Ion Absorption Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding G Protein-coupled Receptor Catabolic Process Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Natural Killer Cell Degranulation Cytolytic Granule Membrane Immune Response To Tumor Cell Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vesicle Receptor Serine/threonine Kinase Binding G Protein-coupled Opioid Receptor Activity Spine Apparatus Microvillus Organization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Type 3 Metabotropic Glutamate Receptor Binding Establishment Of Golgi Localization Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Phospholipase C-activating Dopamine Receptor Signaling Pathway Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding G Protein-coupled Opioid Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Cytolytic Granule Granzyme-mediated Programmed Cell Death Signaling Pathway Cellular Response To Toxic Substance Negative Regulation Of Sodium Ion Transport Gamma-aminobutyric Acid Transport Golgi Localization Maintenance Of Cell Polarity Glutathione Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cerebrospinal Fluid Circulation Phosphatidylethanolamine Binding Cellular Response To Nitrogen Starvation Tat Protein Binding Glycophagy Plasma Membrane Protein Complex