OCRL and CLTC

Number of citations of the paper that reports this interaction (PMID 15917292)
42

Data Source:
HPRD (two hybrid, in vitro)

		OCRL	CLTC
Gene Name		oculocerebrorenal syndrome of Lowe	clathrin, heavy chain (Hc)
Image
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Early Endosome Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Coated Pit Clathrin-coated Vesicle Phagocytic Vesicle Membrane Early Endosome Membrane Extracellular Vesicular Exosome	Cytoplasm Spindle Cytosol Plasma Membrane Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Membrane Vesicle Trans-Golgi Network Membrane Melanosome Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome Clathrin Complex
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Rac GTPase Activator Activity Rac GTPase Binding Inositol Phosphate Phosphatase Activity	Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Poly(A) RNA Binding
	Biological Process	In Utero Embryonic Development Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Small GTPase Mediated Signal Transduction Regulation Of Rac GTPase Activity Positive Regulation Of Rac GTPase Activity Cilium Assembly Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation Regulation Of Small GTPase Mediated Signal Transduction	Osteoblast Differentiation Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Mitotic Nuclear Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Transferrin Transport Membrane Organization Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Golgi Associated Vesicle Biogenesis Clathrin derived vesicle budding Inositol phosphate metabolism Rho GTPase cycle Synthesis of IP3 and IP4 in the cytosol Synthesis of IP2, IP, and Ins in the cytosol Signaling by Rho GTPases Phospholipid metabolism trans-Golgi Network Vesicle Budding PI Metabolism	Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Axon guidance Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking WNT5A-dependent internalization of FZD4 EPH-Ephrin signaling Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CDC42 CLTC GOLGA5 GRB2 RAB14 RAB1A RAB5A RAB6A RAB8A RAC1	60 interactors: AMPH AP1B1 AP1G1 AP2A2 AP2B1 AP3B1 AP3B2 ARMCX3 ARR3 ARRB1 ARRB2 C10orf88 CLINT1 CLTA CLTB DNAJC6 EHD1 EP300 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 NCALD NDRG1 OCRL PICALM PPP1CA PPP1CC PRKACA PXN QARS SCYL2 SNX5 SNX9 SRC STAM STAMBP SYNJ1 TFAP2A TNK2 TOM1 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9
Entrez ID		4952	1213
HPRD ID		02395	00350
Ensembl ID		ENSG00000122126	ENSG00000141367
Uniprot IDs		Q01968	Q00610
PDB IDs		2KIE 2QV2 3QBT 3QIS	2XZG 4G55
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Rab Protein Signal Transduction Ras Protein Signal Transduction Golgi Vesicle Transport Endocytosis Cellular Protein Localization Cellular Localization Intracellular Transport Intracellular Signal Transduction Protein Localization Establishment Of Localization In Cell Transport Endomembrane System Organization Intracellular Protein Transport Receptor Internalization Organelle Transport Along Microtubule Phagocytosis T Cell Costimulation Golgi Organization Receptor Metabolic Process Cell Morphogenesis Involved In Differentiation Establishment Of Organelle Localization Protein Transport Establishment Of Protein Localization Membrane Organization Regulation Of Cell Projection Assembly Cell-cell Signaling Organelle Localization Blood Coagulation Microtubule-based Transport Hemostasis Cytoskeleton-dependent Intracellular Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Morphogenesis Cellular Component Assembly Axonogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Organelle Organization Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Establishment Of Vesicle Localization Wound Healing Endosomal Transport Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of T Cell Activation	Vesicle-mediated Transport Endocytosis Transport Establishment Of Localization In Cell Intracellular Transport Cellular Localization Intracellular Protein Transport Cellular Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport ERBB Signaling Pathway Protein Transport Signaling Establishment Of Protein Localization Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Endocytosis Negative Regulation Of ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Membrane Organization Positive Regulation Of Transport Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Synaptic Transmission Endosomal Transport Negative Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Signal Transduction Regulation Of Defense Response To Virus By Virus Nervous System Development Receptor-mediated Endocytosis Regulation Of Cellular Component Organization Cell-cell Signaling Response To Stimulus Positive Regulation Of Receptor-mediated Endocytosis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Receptor Internalization Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Endocytosis
Tagcloud ?		1016790a cataracts cilia ciliary cilium congenital eye glaucoma gli1 hydrostatic inositol intraocular lowe mechanosensation mechanosensory mechanotransduction meshwork organelles polyphosphate pressure senses shed shorten shortened tm trabecular trpv4 vanilloid vesicular	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Difference) ?		1016790a cataracts cilia ciliary cilium congenital eye glaucoma gli1 hydrostatic inositol intraocular lowe mechanosensation mechanosensory mechanotransduction meshwork organelles polyphosphate pressure senses shed shorten shortened tm trabecular trpv4 vanilloid vesicular	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Intersection) ?