OCRL and GOLGA5

Number of citations of the paper that reports this interaction (PMID 9915833)
13

Data Source:
HPRD (two hybrid)

		OCRL	GOLGA5
Gene Name		oculocerebrorenal syndrome of Lowe	golgin A5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Early Endosome Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Coated Pit Clathrin-coated Vesicle Phagocytic Vesicle Membrane Early Endosome Membrane Extracellular Vesicular Exosome	Golgi Membrane Golgi Apparatus Cis-Golgi Network Membrane Integral Component Of Membrane Golgi Cisterna
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Rac GTPase Activator Activity Rac GTPase Binding Inositol Phosphate Phosphatase Activity	Rab GTPase Binding Protein Homodimerization Activity
	Biological Process	In Utero Embryonic Development Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Small GTPase Mediated Signal Transduction Regulation Of Rac GTPase Activity Positive Regulation Of Rac GTPase Activity Cilium Assembly Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation Regulation Of Small GTPase Mediated Signal Transduction	Golgi Organization Golgi Vesicle Transport
Pathways		Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Golgi Associated Vesicle Biogenesis Clathrin derived vesicle budding Inositol phosphate metabolism Rho GTPase cycle Synthesis of IP3 and IP4 in the cytosol Synthesis of IP2, IP, and Ins in the cytosol Signaling by Rho GTPases Phospholipid metabolism trans-Golgi Network Vesicle Budding PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CDC42 CLTC GOLGA5 GRB2 RAB14 RAB1A RAB5A RAB6A RAB8A RAC1	4 interactors: CUX1 ITSN1 OCRL RAB1A
Entrez ID		4952	9950
HPRD ID		02395	06079
Ensembl ID		ENSG00000122126	ENSG00000066455
Uniprot IDs		Q01968	Q8TBA6
PDB IDs		2KIE 2QV2 3QBT 3QIS
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Rab Protein Signal Transduction Ras Protein Signal Transduction Golgi Vesicle Transport Endocytosis Cellular Protein Localization Cellular Localization Intracellular Transport Intracellular Signal Transduction Protein Localization Establishment Of Localization In Cell Transport Endomembrane System Organization Intracellular Protein Transport Receptor Internalization Organelle Transport Along Microtubule Phagocytosis T Cell Costimulation Golgi Organization Receptor Metabolic Process Cell Morphogenesis Involved In Differentiation Establishment Of Organelle Localization Protein Transport Establishment Of Protein Localization Membrane Organization Regulation Of Cell Projection Assembly Cell-cell Signaling Organelle Localization Blood Coagulation Microtubule-based Transport Hemostasis Cytoskeleton-dependent Intracellular Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Morphogenesis Cellular Component Assembly Axonogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Organelle Organization Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Establishment Of Vesicle Localization Wound Healing Endosomal Transport Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of T Cell Activation	Small GTPase Mediated Signal Transduction Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Cell Morphogenesis Establishment Of Vesicle Localization Positive Regulation Of Metabolic Process Vesicle Localization Positive Regulation Of Rho GTPase Activity Interleukin-8 Production Golgi Vesicle Transport Regulation Of Rho GTPase Activity Vesicle-mediated Transport Establishment Of Organelle Localization Regulation Of Rho Protein Signal Transduction Cargo Loading Into Vesicle Growth Hormone Secretion Organelle Localization Intracellular Signal Transduction Anatomical Structure Development Positive Regulation Of Ras GTPase Activity Establishment Of Localization In Cell Organelle Assembly Positive Regulation Of Glycoprotein Metabolic Process Developmental Process Regulation Of Ras GTPase Activity COPII-coated Vesicle Budding Regulation Of Rac GTPase Activity Virion Assembly Cellular Localization Anatomical Structure Morphogenesis Endocytosis Regulation Of Ras Protein Signal Transduction Positive Regulation Of Cellular Metabolic Process Phosphatidylinositol Dephosphorylation Cell Morphogenesis Involved In Differentiation Positive Regulation Of GTPase Activity Auditory Receptor Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Cytokine Secretion Vesicle Transport Along Microtubule Melanosome Transport Synaptic Vesicle Endocytosis Pigment Granule Transport Regulation Of Rac Protein Signal Transduction Regulation Of GTPase Activity Establishment Of Melanosome Localization Synaptic Vesicle Recycling Positive Regulation Of Dendrite Morphogenesis Hair Cell Differentiation Phospholipid Dephosphorylation
Tagcloud ?		1016790a cataracts cilia ciliary cilium congenital eye glaucoma gli1 hydrostatic inositol intraocular lowe mechanosensation mechanosensory mechanotransduction meshwork organelles polyphosphate pressure senses shed shorten shortened tm trabecular trpv4 vanilloid vesicular	abomasum actb b2m blat butterfat calculating cops7a coro1b cows dnajc19 eif3k emd gapdh genorm goodness gpr175 icg linoleic lipogenic marveld1 mine mrpl39 mtg1 normalization qpcr supplements unsupplemented uxt verification
Tagcloud (Difference) ?		1016790a cataracts cilia ciliary cilium congenital eye glaucoma gli1 hydrostatic inositol intraocular lowe mechanosensation mechanosensory mechanotransduction meshwork organelles polyphosphate pressure senses shed shorten shortened tm trabecular trpv4 vanilloid vesicular	abomasum actb b2m blat butterfat calculating cops7a coro1b cows dnajc19 eif3k emd gapdh genorm goodness gpr175 icg linoleic lipogenic marveld1 mine mrpl39 mtg1 normalization qpcr supplements unsupplemented uxt verification
Tagcloud (Intersection) ?