OCRL and RAB5A

Number of citations of the paper that reports this interaction (PubMedID 16902405)
36

Data Source:
BioGRID (proximity labelling technology)
HPRD (two hybrid, in vitro, in vivo)

		OCRL	RAB5A
Description		OCRL inositol polyphosphate-5-phosphatase	RAB5A, member RAS oncogene family
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosome Endosome Early Endosome Golgi Apparatus Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Cilium Microtubule Cytoskeleton Membrane Clathrin-coated Vesicle Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Centriolar Satellite Ciliary Basal Body Cell Projection Neuron Projection	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Cell Projection Neuronal Cell Body Terminal Bouton Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity GTPase Activator Activity Protein Binding Hydrolase Activity Phosphatase Activity Small GTPase Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Bisphosphate Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Inositol Phosphate Phosphatase Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding GDP Binding
	Biological Process	In Utero Embryonic Development Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Cell Projection Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Cilium Assembly Membrane Organization	Intracellular Protein Transport Endocytosis Phagocytosis Protein Transport Endosomal Transport Receptor Internalization Synaptic Vesicle Recycling Host-mediated Perturbation Of Viral Process Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Endosome Size Regulation Of Filopodium Assembly Canonical Wnt Signaling Pathway Membrane Fusion Amyloid-beta Clearance By Transcytosis Protein Localization To Early Endosome Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis RHOJ GTPase cycle RAC3 GTPase cycle	Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Respiratory syncytial virus (RSV) attachment and entry Factors involved in megakaryocyte development and platelet production
Drugs			L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases		Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis Lowe syndrome; Oculocerebrorenal Dystrophy (OCRL)
GWAS			Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)
Interacting Genes		13 interacting genes: CDC42 CLTC GOLGA5 GRB2 LHX3 RAB14 RAB1A RAB31 RAB5A RAB6A RAB8A RAC1 TFAP2A	37 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 SNCA STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL WEE2-AS1
Entrez ID		4952	5868
HPRD ID		02395	01542
Ensembl ID		ENSG00000122126	ENSG00000144566
Uniprot IDs		A0A2X0TVZ9 Q01968 Q504W7	P20339
PDB IDs		2KIE 2QV2 3QBT 3QIS 4CMN	1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U 7BL1
Enriched GO Terms of Interacting Partners?		GTPase Activity Vesicle-mediated Transport GTP Binding G Protein Activity Phagocytic Vesicle Endocytosis Intracellular Protein Transport Import Into Cell Receptor Internalization Trans-Golgi Network Myosin V Binding GDP Binding Cellular Localization Endosome Intracellular Transport Melanosome Intracellular Protein Localization Trans-Golgi Network Membrane Endosomal Transport Endomembrane System Cytoplasmic Vesicle Golgi Vesicle Transport Golgi Organization Extracellular Exosome Golgi Membrane Establishment Of Localization In Cell Protein Transport Receptor-mediated Endocytosis Hydrolase Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Amyloid-beta Clearance By Transcytosis Regulation Of Neuronal Synaptic Plasticity Early Endosome Membrane Nucleotide Binding Protein Kinase Binding Establishment Of Protein Localization Thioesterase Binding Plasma Membrane Bounded Cell Projection Organization Golgi Apparatus Phagocytic Vesicle Membrane Phagosome Maturation Organelle Transport Along Microtubule Localization Within Membrane Secretory Granule Membrane Retrograde Transport, Endosome To Golgi Recycling Endosome Membrane Trans-Golgi Network Transport Vesicle Early Endosome To Golgi Transport Protein Localization To Membrane Anatomical Structure Arrangement	GTPase Activator Activity Small GTPase Binding Vesicle-mediated Transport Endosome Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Endocytosis Cytoplasmic Vesicle Regulation Of Cellular Component Organization Cellular Localization Import Into Cell Intracellular Transport Regulation Of Cilium Assembly Endosomal Transport Small GTPase-mediated Signal Transduction Macropinosome Establishment Of Protein Localization Protein Transport Early Endosome Membrane Cytosol Establishment Of Localization In Cell Positive Regulation Of Pinocytosis Regulation Of Transport Early Endosome Regulation Of Organelle Assembly Cytoplasm Positive Regulation Of Macropinocytosis Regulation Of Cell Projection Assembly Endocytic Vesicle Membrane Fusion Positive Regulation Of Endocytosis Rab-protein Geranylgeranyltransferase Complex Phagocytic Vesicle Signal Transduction Intracellular Protein Localization Vesicle Fusion Retrograde Transport, Endosome To Golgi Protein Geranylgeranylation Organelle Membrane Fusion Ruffle Guanyl-nucleotide Exchange Factor Activity Synapse Adiponectin-activated Signaling Pathway Regulation Of Organelle Organization Protein Prenylation Organelle Fusion Cytosolic Transport Plasma Membrane To Endosome Transport Recycling Endosome Cell Projection
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