OCRL and RAB14

Number of citations of the paper that reports this interaction (PMID 16902405)
44

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		OCRL	RAB14
Gene Name		oculocerebrorenal syndrome of Lowe	RAB14, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Early Endosome Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Coated Pit Clathrin-coated Vesicle Phagocytic Vesicle Membrane Early Endosome Membrane Extracellular Vesicular Exosome	Golgi Membrane Intracellular Lysosome Lysosomal Membrane Early Endosome Late Endosome Rough Endoplasmic Reticulum Golgi Apparatus Golgi Stack Cytosol Plasma Membrane Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Primary Cilium
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Rac GTPase Activator Activity Rac GTPase Binding Inositol Phosphate Phosphatase Activity	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding
	Biological Process	In Utero Embryonic Development Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Small GTPase Mediated Signal Transduction Regulation Of Rac GTPase Activity Positive Regulation Of Rac GTPase Activity Cilium Assembly Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation Regulation Of Small GTPase Mediated Signal Transduction	Intracellular Protein Transport Golgi To Endosome Transport Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Vesicle-mediated Transport Endocytic Recycling Rab Protein Signal Transduction Regulation Of Protein Localization Intracellular Transport Membrane Organization Phagolysosome Assembly Involved In Apoptotic Cell Clearance
Pathways		Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Golgi Associated Vesicle Biogenesis Clathrin derived vesicle budding Inositol phosphate metabolism Rho GTPase cycle Synthesis of IP3 and IP4 in the cytosol Synthesis of IP2, IP, and Ins in the cytosol Signaling by Rho GTPases Phospholipid metabolism trans-Golgi Network Vesicle Budding PI Metabolism	Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		10 interactors: CDC42 CLTC GOLGA5 GRB2 RAB14 RAB1A RAB5A RAB6A RAB8A RAC1	9 interactors: APP CHM EXOC5 OCRL OPTN RAB11FIP5 RBSN RUFY1 SMURF2
Entrez ID		4952	51552
HPRD ID		02395	06693
Ensembl ID		ENSG00000122126	ENSG00000119396
Uniprot IDs		Q01968	P61106
PDB IDs		2KIE 2QV2 3QBT 3QIS	1Z0F 4DRZ
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Rab Protein Signal Transduction Ras Protein Signal Transduction Golgi Vesicle Transport Endocytosis Cellular Protein Localization Cellular Localization Intracellular Transport Intracellular Signal Transduction Protein Localization Establishment Of Localization In Cell Transport Endomembrane System Organization Intracellular Protein Transport Receptor Internalization Organelle Transport Along Microtubule Phagocytosis T Cell Costimulation Golgi Organization Receptor Metabolic Process Cell Morphogenesis Involved In Differentiation Establishment Of Organelle Localization Protein Transport Establishment Of Protein Localization Membrane Organization Regulation Of Cell Projection Assembly Cell-cell Signaling Organelle Localization Blood Coagulation Microtubule-based Transport Hemostasis Cytoskeleton-dependent Intracellular Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Morphogenesis Cellular Component Assembly Axonogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Organelle Organization Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Establishment Of Vesicle Localization Wound Healing Endosomal Transport Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of T Cell Activation	Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Exocytosis Protein Localization Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Cellular Localization Secretion By Cell Synaptic Growth At Neuromuscular Junction Intracellular Transport Secretion Collateral Sprouting In Absence Of Injury Negative Regulation Of Receptor Recycling Transport Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Insulin Secretion Involved In Cellular Response To Glucose Stimulus Axon Choice Point Recognition Golgi Ribbon Formation Ubiquitin-dependent SMAD Protein Catabolic Process Membrane Organization Cellular Response To Acidic PH Protein Geranylgeranylation Establishment Of Protein Localization To Membrane Neuron Remodeling Golgi Vesicle Transport Positive Regulation Of Hydrolase Activity
Tagcloud ?		1016790a cataracts cilia ciliary cilium congenital eye glaucoma gli1 hydrostatic inositol intraocular lowe mechanosensation mechanosensory mechanotransduction meshwork organelles polyphosphate pressure senses shed shorten shortened tm trabecular trpv4 vanilloid vesicular	a2 abundantly alveolar annexin bodies details egfp immunoprecipitated indeed interference lamellar localized microarray nevertheless overexpressing phospholipid regulated rescued returned secretion selected silenced silencing surfactant tagged targets thirteen transcriptome validated
Tagcloud (Difference) ?		1016790a cataracts cilia ciliary cilium congenital eye glaucoma gli1 hydrostatic inositol intraocular lowe mechanosensation mechanosensory mechanotransduction meshwork organelles polyphosphate pressure senses shed shorten shortened tm trabecular trpv4 vanilloid vesicular	a2 abundantly alveolar annexin bodies details egfp immunoprecipitated indeed interference lamellar localized microarray nevertheless overexpressing phospholipid regulated rescued returned secretion selected silenced silencing surfactant tagged targets thirteen transcriptome validated
Tagcloud (Intersection) ?