OCRL and RAB6A

Number of citations of the paper that reports this interaction (PMID 16902405)
44

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		OCRL	RAB6A
Gene Name		oculocerebrorenal syndrome of Lowe	RAB6A, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Early Endosome Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Coated Pit Clathrin-coated Vesicle Phagocytic Vesicle Membrane Early Endosome Membrane Extracellular Vesicular Exosome	Golgi Membrane Golgi Apparatus Trans-Golgi Network Cytosol Membrane Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Rac GTPase Activator Activity Rac GTPase Binding Inositol Phosphate Phosphatase Activity	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	In Utero Embryonic Development Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Small GTPase Mediated Signal Transduction Regulation Of Rac GTPase Activity Positive Regulation Of Rac GTPase Activity Cilium Assembly Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation Regulation Of Small GTPase Mediated Signal Transduction	Protein Targeting To Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Peptidyl-cysteine Methylation Antigen Processing And Presentation Rab Protein Signal Transduction Protein Localization To Golgi Apparatus Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Minus-end-directed Organelle Transport Along Microtubule
Pathways		Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Golgi Associated Vesicle Biogenesis Clathrin derived vesicle budding Inositol phosphate metabolism Rho GTPase cycle Synthesis of IP3 and IP4 in the cytosol Synthesis of IP2, IP, and Ins in the cytosol Signaling by Rho GTPases Phospholipid metabolism trans-Golgi Network Vesicle Budding PI Metabolism	Pre-NOTCH Processing in Golgi Signaling by NOTCH Pre-NOTCH Expression and Processing
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: CDC42 CLTC GOLGA5 GRB2 RAB14 RAB1A RAB5A RAB6A RAB8A RAC1	20 interactors: BICD1 BICD2 CHM CHML DCTN1 ERC1 FKBP2 GDI1 GOLGA1 GOLGA2 GOLGA4 KIF20A OCRL PMM1 RAB7A RABAC1 RABGAP1 RABGGTB SYTL5 TMF1
Entrez ID		4952	5870
HPRD ID		02395	01543
Ensembl ID		ENSG00000122126	ENSG00000175582
Uniprot IDs		Q01968	P20340 Q53ET8
PDB IDs		2KIE 2QV2 3QBT 3QIS	1YZQ 2GIL 3BBP 3CWZ 4DKX
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Rab Protein Signal Transduction Ras Protein Signal Transduction Golgi Vesicle Transport Endocytosis Cellular Protein Localization Cellular Localization Intracellular Transport Intracellular Signal Transduction Protein Localization Establishment Of Localization In Cell Transport Endomembrane System Organization Intracellular Protein Transport Receptor Internalization Organelle Transport Along Microtubule Phagocytosis T Cell Costimulation Golgi Organization Receptor Metabolic Process Cell Morphogenesis Involved In Differentiation Establishment Of Organelle Localization Protein Transport Establishment Of Protein Localization Membrane Organization Regulation Of Cell Projection Assembly Cell-cell Signaling Organelle Localization Blood Coagulation Microtubule-based Transport Hemostasis Cytoskeleton-dependent Intracellular Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Morphogenesis Cellular Component Assembly Axonogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Organelle Organization Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Establishment Of Vesicle Localization Wound Healing Endosomal Transport Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of T Cell Activation	Protein Geranylgeranylation Protein Localization Establishment Of Localization In Cell Intracellular Transport Cellular Localization Protein Prenylation Protein Transport Establishment Of Protein Localization Minus-end-directed Organelle Transport Along Microtubule Cellular Protein Localization Transport Retrograde Transport, Endosome To Golgi Microtubule Anchoring At Microtubule Organizing Center Intracellular Protein Transport Vesicle-mediated Transport Microtubule-based Movement Positive Regulation Of Hydrolase Activity Microtubule-based Transport Protein Targeting To Golgi Cytoskeleton-dependent Intracellular Transport Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Protein Targeting Organelle Assembly Protein Localization To Golgi Apparatus Endosomal Transport Protein Localization To Organelle Regulation Of Proteinase Activated Receptor Activity Epidermal Growth Factor Catabolic Process Negative Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Testosterone Secretion Positive Regulation Of Catalytic Activity Organelle Transport Along Microtubule Intra-Golgi Vesicle-mediated Transport Microtubule Anchoring Rab Protein Signal Transduction Regulation Of Catalytic Activity Luteinizing Hormone Secretion Negative Regulation Of Phospholipase C Activity Positive Regulation Of Androgen Secretion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Establishment Of Protein Localization To Organelle Microtubule-based Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Phagosome-lysosome Fusion Phagosome Acidification Negative Regulation Of Protein Targeting To Membrane
Tagcloud ?		1016790a cataracts cilia ciliary cilium congenital eye glaucoma gli1 hydrostatic inositol intraocular lowe mechanosensation mechanosensory mechanotransduction meshwork organelles polyphosphate pressure senses shed shorten shortened tm trabecular trpv4 vanilloid vesicular	autosomal axonal causal coh1 cohen constitutively disability dystrophy golgi gtpase inactive integrity intellectual interfered microcephaly neurite neuritogenesis outgrowth preferentially preparations prevents q72l recessive rnai scaffold solubilization t27n vps13b
Tagcloud (Difference) ?		1016790a cataracts cilia ciliary cilium congenital eye glaucoma gli1 hydrostatic inositol intraocular lowe mechanosensation mechanosensory mechanotransduction meshwork organelles polyphosphate pressure senses shed shorten shortened tm trabecular trpv4 vanilloid vesicular	autosomal axonal causal coh1 cohen constitutively disability dystrophy golgi gtpase inactive integrity intellectual interfered microcephaly neurite neuritogenesis outgrowth preferentially preparations prevents q72l recessive rnai scaffold solubilization t27n vps13b
Tagcloud (Intersection) ?