HIST2H2BE and IL33

Number of citations of the paper that reports this interaction (PMID 18688256)
29

Data Source:
BioGRID (pull down)

		HIST2H2BE	IL33
Gene Name		histone cluster 2, H2be	interleukin 33
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Extracellular Vesicular Exosome	Extracellular Space Nucleus Chromosome Transport Vesicle
	Molecular Function	DNA Binding Protein Heterodimerization Activity	Cytokine Activity Protein Binding
	Biological Process	Innate Immune Response In Mucosa Chromatin Organization Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium	Negative Regulation Of Leukocyte Migration Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Type 2 Immune Response Transcription, DNA-templated Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Type 2 Immune Response Positive Regulation Of Macrophage Activation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Inflammatory Response Positive Regulation Of Immunoglobulin Secretion Negative Regulation Of Immunoglobulin Secretion Positive Regulation Of Chemokine Secretion Extrinsic Apoptotic Signaling Pathway
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS			Asthma ( 21804549 20860503) Endometriosis ( 23472165) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		74 interactors: AIRE AKT1 ANP32A ARID1B ATF2 ATXN7L3 BAZ1B BRD2 BRD7 CDK9 CHFR CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HIST1H4A HIST2H2AC HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 MST1 NAP1L4 NCL NPM1 PARP10 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF20 RNF40 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMARCA4 SSRP1 STK4 TAF1A TAF1B TBL1X TBL1XR1 TCF20 TGM2 TNPO1 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 VRK1	5 interactors: CASP1 CRMP1 HIST2H2AA3 HIST2H2BE IL1RL1
Entrez ID		8349	90865
HPRD ID		03494	12275
Ensembl ID		ENSG00000184678	ENSG00000137033
Uniprot IDs		Q16778	O95760
PDB IDs			2KLL 4KC3
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Organelle Organization Cellular Protein Modification Process Cellular Metabolic Process Regulation Of Gene Expression Gene Expression Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Chromatin Remodeling Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Assembly Or Disassembly Protein Catabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Histone Acetylation Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Internal Peptidyl-lysine Acetylation Cellular Protein Catabolic Process Viral Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation	Positive Regulation Of Cytokine Secretion Interleukin-33-mediated Signaling Pathway Regulation Of Cytokine Secretion Mitochondrial Depolarization Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Protein Secretion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Regulation Of Inflammatory Response Immune Response Negative Regulation Of T-helper 1 Type Immune Response Pyrimidine Nucleobase Catabolic Process Positive Regulation Of Secretion Positive Regulation Of Chemokine Secretion Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Positive Regulation Of Macrophage Activation Regulation Of Protein Secretion Interleukin-1 Beta Production Positive Regulation Of Interleukin-5 Production Innate Immune Response In Mucosa Response To Bacterium Response To External Stimulus Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Cytokine Production Regulation Of Interleukin-1 Beta Secretion Regulation Of Macrophage Activation Regulation Of Interleukin-5 Production Response To ATP Antibacterial Humoral Response Antimicrobial Humoral Response Positive Regulation Of Interleukin-1 Beta Production Regulation Of Protein Transport Immune System Process Positive Regulation Of Interleukin-1 Production Mucosal Immune Response Regulation Of Secretion Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Interferon-gamma Production Regulation Of Establishment Of Protein Localization Negative Regulation Of Adaptive Immune Response Membrane Hyperpolarization Pyrimidine Nucleobase Metabolic Process Toxin Transport Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Other Organism Positive Regulation Of Chemokine Production Positive Regulation Of Transport
Tagcloud ?		5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis	10ko acp5 aia arthritic arthritis autoinflammatory blockade casp1 driven erosions ex exogenous focal hence histological histopathology il1b inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Difference) ?		5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis	10ko acp5 aia arthritic arthritis autoinflammatory blockade casp1 driven erosions ex exogenous focal hence histological histopathology il1b inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Intersection) ?