HIST2H2BE and STK4

Number of citations of the paper that reports this interaction (PMID 12757711)
114

Data Source:
BioGRID (enzymatic study, enzymatic study)

		HIST2H2BE	STK4
Gene Name		histone cluster 2, H2be	serine/threonine kinase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Heterodimerization Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Dimerization Activity
	Biological Process	Innate Immune Response In Mucosa Chromatin Organization Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium	Cell Morphogenesis Patterning Of Blood Vessels Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Proliferation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation Keratinocyte Differentiation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		74 interactors: AIRE AKT1 ANP32A ARID1B ATF2 ATXN7L3 BAZ1B BRD2 BRD7 CDK9 CHFR CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HIST1H4A HIST2H2AC HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 MST1 NAP1L4 NCL NPM1 PARP10 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF20 RNF40 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMARCA4 SSRP1 STK4 TAF1A TAF1B TBL1X TBL1XR1 TCF20 TGM2 TNPO1 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 VRK1	16 interactors: AKT1 CASP3 CNKSR1 CSN1S1 HIST2H2BE IL2RG LATS1 MBP NEDD4 PRKRIR RASSF1 RASSF5 SAV1 SGMS1 SIRT1 TP53
Entrez ID		8349	6789
HPRD ID		03494	05395
Ensembl ID		ENSG00000184678	ENSG00000101109
Uniprot IDs		Q16778	Q13043
PDB IDs			2JO8 3COM
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Organelle Organization Cellular Protein Modification Process Cellular Metabolic Process Regulation Of Gene Expression Gene Expression Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Chromatin Remodeling Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Assembly Or Disassembly Protein Catabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Histone Acetylation Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Internal Peptidyl-lysine Acetylation Cellular Protein Catabolic Process Viral Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation	Response To Cytokine Positive Regulation Of Protein Metabolic Process Hippo Signaling Intracellular Signal Transduction Response To Tumor Necrosis Factor Negative Regulation Of Helicase Activity Response To Stimulus Response To UV Signaling Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Aging Intrinsic Apoptotic Signaling Pathway Glial Cell Apoptotic Process Response To Radiation Response To Organic Substance Signal Transduction Cellular Response To Organic Substance Negative Regulation Of Protein Kinase Activity Apoptotic Mitochondrial Changes Cellular Response To Stimulus Response To Stress Negative Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Apoptotic Process Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Programmed Cell Death Keratinocyte Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Neuron Death Cell Death Cellular Response To Hypoxia Death Positive Regulation Of Cell Death Cellular Response To Decreased Oxygen Levels Negative Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Autophagy Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Phosphorylation Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Aging Cellular Response To Oxygen Levels Negative Regulation Of Cell Proliferation Response To Light Stimulus Apoptotic Signaling Pathway
Tagcloud ?		5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis	abl1 centered coactivator damage elicits hematologic hematological hippo inactivation instability lethal malignancies myeloma notably oncogene ongoing pervasive presenting proapoptotic relevance relocalization restores selectively serine synthetic threonine triggering triggers yap1
Tagcloud (Difference) ?		5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis	abl1 centered coactivator damage elicits hematologic hematological hippo inactivation instability lethal malignancies myeloma notably oncogene ongoing pervasive presenting proapoptotic relevance relocalization restores selectively serine synthetic threonine triggering triggers yap1
Tagcloud (Intersection) ?