HIST2H2BE and VRK1

Number of citations of the paper that reports this interaction (PMID 17938195)
28

Data Source:
BioGRID (pull down)

		HIST2H2BE	VRK1
Gene Name		histone cluster 2, H2be	vaccinia related kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Spindle Cytosol
	Molecular Function	DNA Binding Protein Heterodimerization Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Nucleosomal Histone Binding Histone Kinase Activity (H3-S10 Specific) Histone Kinase Activity (H3-T3 Specific)
	Biological Process	Innate Immune Response In Mucosa Chromatin Organization Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium	Mitotic Cell Cycle Protein Phosphorylation Endocytosis Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Mitotic Nuclear Envelope Reassembly Regulation Of Cell Shape Wnt Signaling Pathway Histone H3-S10 Phosphorylation Protein Autophosphorylation Cell Division Histone H3-T3 Phosphorylation Golgi Disassembly
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Mitotic Prophase Nuclear Envelope Breakdown Nuclear Envelope Reassembly Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase Initiation of Nuclear Envelope Reformation Cell Cycle, Mitotic M Phase Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS			Neutrophil count ( 21507922)
Protein-Protein Interactions		74 interactors: AIRE AKT1 ANP32A ARID1B ATF2 ATXN7L3 BAZ1B BRD2 BRD7 CDK9 CHFR CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HIST1H4A HIST2H2AC HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 MST1 NAP1L4 NCL NPM1 PARP10 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF20 RNF40 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMARCA4 SSRP1 STK4 TAF1A TAF1B TBL1X TBL1XR1 TCF20 TGM2 TNPO1 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 VRK1	5 interactors: HIST2H2BE HIST2H3C PLK3 SRPK2 TP53
Entrez ID		8349	7443
HPRD ID		03494	03701
Ensembl ID		ENSG00000184678	ENSG00000100749
Uniprot IDs		Q16778	Q99986
PDB IDs			2KTY 2KUL 2LAV 3OP5
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Organelle Organization Cellular Protein Modification Process Cellular Metabolic Process Regulation Of Gene Expression Gene Expression Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Chromatin Remodeling Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Assembly Or Disassembly Protein Catabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Histone Acetylation Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Internal Peptidyl-lysine Acetylation Cellular Protein Catabolic Process Viral Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation	Positive Regulation Of Neuron Apoptotic Process Response To Stress Mitotic G1/S Transition Checkpoint Positive Regulation Of Neuron Death Response To Osmotic Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Nuclear Speck Organization Cellular Response To Oxygen Levels Chromatin Assembly Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia Chromatin Assembly Or Disassembly Mitotic Cell Cycle Checkpoint Regulation Of Cell Cycle DNA Packaging Golgi Disassembly Endomitotic Cell Cycle Negative Regulation Of Helicase Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Cell Cycle Checkpoint Regulation Of Neuron Apoptotic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Intracellular Transport Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process DNA Conformation Change Mitochondrial DNA Repair Positive Regulation Of Cell Cycle Organelle Organization Regulation Of Neuron Death Immune Response Response To Hypoxia Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Golgi Inheritance Glial Cell Apoptotic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Oxidative Stress-induced Premature Senescence ER Overload Response Regulation Of Apoptotic Process Negative Regulation Of Macroautophagy Stress-induced Premature Senescence Regulation Of Cell Death DNA Methylation On Cytosine
Tagcloud ?		5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis	affects ashkenazi atrophy dead electroporation founder homozygosity hypoplasia impairs infantile jews manifestations microcephaly migration muscular neuronal noncatalytic nonsense origins partly pch pontocerebellar r358x rescues shrna sma threonine utero vaccinia
Tagcloud (Difference) ?		5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis	affects ashkenazi atrophy dead electroporation founder homozygosity hypoplasia impairs infantile jews manifestations microcephaly migration muscular neuronal noncatalytic nonsense origins partly pch pontocerebellar r358x rescues shrna sma threonine utero vaccinia
Tagcloud (Intersection) ?