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H2BC21 and UBE2A
Number of citations of the paper that reports this interaction (PubMedID
28031328
)
35
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
H2BC21
UBE2A
Description
H2B clustered histone 21
ubiquitin conjugating enzyme E2 A
Image
GO Annotations
Cellular Component
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Chromosome
Cytosol
Extracellular Exosome
Chromatin
Nucleoplasm
Lysosome
Endosome
Late Endosome
Cytosol
HULC Complex
Molecular Function
DNA Binding
Protein Binding
Structural Constituent Of Chromatin
Protein Heterodimerization Activity
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Innate Immune Response In Mucosa
Nucleosome Assembly
Antibacterial Humoral Response
Defense Response To Bacterium
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Cytoplasmic Translation
DNA Repair
Postreplication Repair
Chromatin Organization
Chromatin Remodeling
Ubiquitin-dependent Protein Catabolic Process
DNA Damage Response
Response To UV
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Positive Regulation Of Mitophagy
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Replacement of protamines by nucleosomes in the male pronucleus
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Brain connectivity (
23471985
)
Interacting Genes
73 interacting genes:
AIRE
AKT1
ANP32A
AP2M1
ARID1B
ATF2
ATXN7L3
BRD7
CDK9
CREBBP
DNMT3L
DYRK2
EP300
GADD45A
GATAD2A
GATAD2B
GZMA
HDAC2
HIPK2
HIRA
HIRIP3
HSPD1
IL33
IL7R
KAT2A
KAT2B
KPNA1
LALBA
LOX
MAP4K4
MDM2
MSL1
MSL2
NAP1L4
NCL
NEIL3
NPM1
PARP10
PARP9
PBRM1
PELP1
PRMT6
PTMA
RAG1
RCC1
RNF168
RNF20
RNF8
RPS6KA5
SAP30
SART3
SIRT7
SMU1
SPANXN2
STK38
STK4
TAF1A
TAF1B
TBL1X
TBL1XR1
TGM2
TNPO1
TRAF6
TSPY1
UBC
UBE2A
USP12
USP15
USP22
USP46
USP49
USP8
VRK1
32 interacting genes:
CBX5
CDK1
CDK2
CDK9
CDKN2A
CRMP1
EEF1D
H2BC21
H2BC3
HECTD3
HLTF
KCMF1
MDM2
PCNA
PRKN
PSMG1
RAD18
RC3H1
RNF167
RNF20
RNF4
RNF40
SDCBP
TP53
TRIM27
UBA1
UBA6
UBC
UBR1
UBR3
UBR5
ZMYM2
Entrez ID
8349
7319
HPRD ID
03494
02422
Ensembl ID
ENSG00000184678
ENSG00000077721
Uniprot IDs
Q16778
A0A0D9SG71
P49459
PDB IDs
4NFT
6A7U
6KBB
6M4D
6M4G
6M4H
7BXT
7EA8
7U0G
7U0I
7U0J
8DK5
8EVG
8EVH
8EVI
8EVJ
8H1T
8SPS
8SPU
8SYP
8UQ8
8UQ9
8UQA
8UQB
8UQC
8UQD
8UQE
8YJF
6CYO
6CYR
8BTL
8IEJ
Enriched GO Terms of Interacting Partners
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Chromatin Organization
Chromatin Remodeling
Histone Binding
Nucleoplasm
Nucleus
Protein Modification Process
Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Chromatin Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Protein Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Damage Response
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Cellular Response To Stress
Post-translational Protein Modification
Regulation Of DNA Metabolic Process
Regulation Of DNA Repair
Negative Regulation Of Macromolecule Metabolic Process
Transferase Activity
Nucleic Acid Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Epigenetic Regulation Of Gene Expression
Cellular Response To Stress
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein-containing Complex
Positive Regulation Of Transcription By RNA Polymerase II
Transcription Coactivator Activity
Regulation Of Signal Transduction By P53 Class Mediator
Histone H3K18 Acetyltransferase Activity
Post-translational Protein Modification
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Ubiquitin Protein Ligase Activity
Protein Modification Process
Ubiquitin-protein Transferase Activity
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein Polyubiquitination
Protein Metabolic Process
Cellular Response To Stress
Macromolecule Catabolic Process
Transferase Activity
DNA Damage Response
Proteolysis
Catabolic Process
Chromatin Organization
Protein K63-linked Ubiquitination
Macromolecule Metabolic Process
Response To Stress
Nucleoplasm
PML Body
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Chromatin Remodeling
Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Response To Oxidative Stress
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K29-linked Ubiquitination
Ubiquitin Ligase Complex
Regulation Of Transcription By RNA Polymerase II
Proteasomal Protein Catabolic Process
Nucleus
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
SUMO Transferase Activity
Positive Regulation Of Metabolic Process
Cellular Response To Hydrogen Peroxide
Protein Autoubiquitination
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
P53 Binding
Regulation Of RNA Biosynthetic Process
Cyclin-dependent Protein Kinase Activity
Cellular Response To Actinomycin D
Ubiquitin Activating Enzyme Activity
Negative Regulation Of DNA-templated Transcription
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Tagcloud (Intersection)
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