ARF1 and AGAP2

Number of citations of the paper that reports this interaction (PubMedID 22453919)
69

Data Source:
BioGRID (enzymatic study)

		ARF1	AGAP2
Description		ARF GTPase 1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endomembrane System Postsynaptic Density Membrane Sarcomere Cell Leading Edge Protein-containing Complex Neuron Projection Synapse Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Membrane Extracellular Exosome Flemming Body
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Zinc Ion Binding Protein Kinase Binding Protein Kinase Activator Activity Phosphatidylinositol 3-kinase Regulator Activity Metal Ion Binding Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Regulation Of Receptor Internalization Intracellular Copper Ion Homeostasis Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Long-term Synaptic Depression Dendritic Spine Organization Cellular Response To Virus Mitotic Cleavage Furrow Ingression	Protein Transport Endosomal Transport Actin Cytoskeleton Organization Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Kinase Activity
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Glycosphingolipid transport	Netrin-1 signaling
Drugs		1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Chlortetracycline Glycerin
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091)	Heel bone mineral density ( 30598549) Multiple sclerosis ( 21833088)
Interacting Genes		50 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DENND1A DENND1B DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 SNCA TMED10 TMED2 TMEM106A WBP11	16 interacting genes: AKT1 ARF1 BTG3 CDC42 CDK4 EPB41L1 GRIP1 HOMER1 HOMER2 NF2 PIK3R1 PLCG1 PRKAA1 RAC1 RAC2 RHOA
Entrez ID		375	116986
HPRD ID		00054	05687
Ensembl ID		ENSG00000143761	ENSG00000135439
Uniprot IDs		P84077	Q99490
PDB IDs		1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE 7DN8 7DN9 7MGE 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9U 8D9W 8SDW 9C58 9C59 9C5A 9C5B	2BMJ 2IWR 2RLO
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Protein Localization Golgi Apparatus Protein Transport Establishment Of Protein Localization Cellular Localization Intracellular Transport Establishment Of Localization In Cell Golgi Vesicle Transport Intracellular Protein Transport Membrane Coat Golgi Membrane Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Trans-Golgi Network Membrane Melanosome Assembly Localization Within Membrane Platelet Dense Granule Organization Post-Golgi Vesicle-mediated Transport Vesicle Cargo Loading COPI Vesicle Coat COPI-coated Vesicle Melanosome Organization Pigment Granule Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Protein Localization To Membrane Golgi To Vacuole Transport Early Endosome Transport Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Trans-Golgi Network Secretory Granule Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Localization To Cell Surface Intra-Golgi Vesicle-mediated Transport Organelle Organization Vesicle Organization Clathrin-coated Vesicle Membrane Synaptic Vesicle Transport Vesicle Coating AP-3 Adaptor Complex Protein Localization To Cell Periphery Endocytosis Clathrin Adaptor Complex Organelle Transport Along Microtubule Cytosol Synaptic Vesicle Budding From Endosome Vacuolar Transport	Intracellular Signaling Cassette Intracellular Signal Transduction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Transport Regulation Of Stress Fiber Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Actin Filament-based Process Regulation Of Cell-substrate Adhesion Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cell Projection Organization Cytosol Membrane Invagination Regulation Of Actin Filament Organization Dendrite Regulation Of Lamellipodium Organization Positive Regulation Of Stress Fiber Assembly Cytoplasm Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Vesicle-mediated Transport Regulation Of Organelle Organization Positive Regulation Of Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Cell Projection Organization Cell Projection Actin Cytoskeleton Organization Positive Regulation Of Locomotion Signal Transduction Regulation Of Supramolecular Fiber Organization Apical Part Of Cell Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Actin Filament-based Process Regulation Of Leukocyte Migration Positive Regulation Of Immune System Process Postsynapse Regulation Of Cell Projection Assembly Regulation Of Cell Motility Ruffle Membrane G Protein-coupled Glutamate Receptor Binding Regulation Of Cellular Component Organization Protein Kinase Binding Regulation Of Locomotion
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