ARF1 and PLEKHA8

Number of citations of the paper that reports this interaction (PubMedID 15107860)
0

Data Source:
HPRD (in vitro)

		ARF1	PLEKHA8
Description		ARF GTPase 1	pleckstrin homology domain containing A8
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endomembrane System Postsynaptic Density Membrane Sarcomere Cell Leading Edge Protein-containing Complex Neuron Projection Synapse Extracellular Exosome	Golgi Membrane Nucleoplasm Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding	Protein Binding Lipid Binding Glycolipid Transfer Activity Glycolipid Binding Phosphatidylinositol-4-phosphate Binding Ceramide Binding Lipid Transfer Activity Ceramide 1-phosphate Binding Ceramide 1-phosphate Transfer Activity
	Biological Process	Regulation Of Receptor Internalization Intracellular Copper Ion Homeostasis Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Long-term Synaptic Depression Dendritic Spine Organization Cellular Response To Virus Mitotic Cleavage Furrow Ingression	Lipid Transport Protein Transport ER To Golgi Ceramide Transport Ceramide Transport Glycolipid Transport Intermembrane Lipid Transfer Ceramide 1-phosphate Transport
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Glycosphingolipid transport	Synthesis of PIPs at the plasma membrane Glycosphingolipid transport
Drugs		1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Chlortetracycline Glycerin
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091)	Estradiol levels ( 22675492) Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292)
Interacting Genes		50 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DENND1A DENND1B DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 SNCA TMED10 TMED2 TMEM106A WBP11	1 interacting genes: ARF1
Entrez ID		375	84725
HPRD ID		00054	10555
Ensembl ID		ENSG00000143761	ENSG00000106086
Uniprot IDs		P84077	A0A087X1S6 A0A2P1JJM6 B5MDU3 Q96JA3
PDB IDs		1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE 7DN8 7DN9 7MGE 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9U 8D9W 8SDW 9C58 9C59 9C5A 9C5B	5KDI
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Protein Localization Golgi Apparatus Protein Transport Establishment Of Protein Localization Cellular Localization Intracellular Transport Establishment Of Localization In Cell Golgi Vesicle Transport Intracellular Protein Transport Membrane Coat Golgi Membrane Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Trans-Golgi Network Membrane Melanosome Assembly Localization Within Membrane Platelet Dense Granule Organization Post-Golgi Vesicle-mediated Transport Vesicle Cargo Loading COPI Vesicle Coat COPI-coated Vesicle Melanosome Organization Pigment Granule Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Protein Localization To Membrane Golgi To Vacuole Transport Early Endosome Transport Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Trans-Golgi Network Secretory Granule Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Localization To Cell Surface Intra-Golgi Vesicle-mediated Transport Organelle Organization Vesicle Organization Clathrin-coated Vesicle Membrane Synaptic Vesicle Transport Vesicle Coating AP-3 Adaptor Complex Protein Localization To Cell Periphery Endocytosis Clathrin Adaptor Complex Organelle Transport Along Microtubule Cytosol Synaptic Vesicle Budding From Endosome Vacuolar Transport	Mitotic Cleavage Furrow Ingression Cleavage Furrow Ingression Mitotic Cytokinetic Process Neuron Projection Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Intracellular Copper Ion Homeostasis Dendritic Spine Organization Postsynapse Organization Membrane Invagination Copper Ion Homeostasis Long-term Synaptic Depression Negative Regulation Of Synaptic Transmission Cytokinetic Process Regulation Of Actin Nucleation Sarcomere Cell Leading Edge Regulation Of Receptor Internalization Cellular Response To Virus Regulation Of Receptor-mediated Endocytosis
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