ARF1 and ARHGAP21

Number of citations: 37 (PubMedID 17347647)
Data Source: HPRD (two hybrid, in vitro)

		ARF1	ARHGAP21
Name		ARF GTPase 1	Rho GTPase activating protein 21
Structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endomembrane System Postsynaptic Density Membrane Sarcomere Cell Leading Edge Protein-containing Complex Neuron Projection Synapse Extracellular Exosome	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Cell Junction Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Anchoring Junction
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding	GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Receptor Internalization Intracellular Copper Ion Homeostasis Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Long-term Synaptic Depression Dendritic Spine Organization Cellular Response To Virus Mitotic Cleavage Furrow Ingression	Golgi Organization Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Golgi Localization Establishment Of Golgi Localization Maintenance Of Golgi Location Organelle Transport Along Microtubule
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Glycosphingolipid transport	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND3 GTPase cycle
Drugs		1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Chlortetracycline Glycerin	None
GWAS		Adolescent idiopathic scoliosis ( 31417091 )	Advanced age-related macular degeneration ( 26691988 ) Appendicular lean mass ( 33097823 ) Birth weight ( 31043758 ) Diisocyanate-induced asthma ( 25918132 ) Immature fraction of reticulocytes ( 32888494 ) Lobe attachment (rater scored) ( 29198719 ) Lobe attachment (rater-scored or self-reported) ( 29198719 ) Optic disc area ( 31798171 ) Optic disc size ( 31809533 ) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770 ) Triglyceride levels x loop diuretics use interaction ( 31806883 )
Novel Interactors		None recorded	1 novel interactors: ODAD2
Interacting Genes		50 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DENND1A DENND1B DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 SNCA TMED10 TMED2 TMEM106A WBP11	9 interacting genes: ARF1 EEF1D PCNT PTK2B RHOA SP1 TULP3 VPS26C ZNF177
Entrez ID		375	57584
HPRD ID		00054	06445
Ensembl ID		ENSG00000143761	ENSG00000107863
Uniprot IDs		P84077	A0A805TBS0 Q5T5U3
PDB IDs		1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE 7DN8 7DN9 7MGE 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9U 8D9W 8SDW 9C58 9C59 9C5A 9C5B	2DHJ 2J59 2YUY
GO Terms Enriched among Interactors		Vesicle-mediated Transport Intracellular Protein Localization Golgi Apparatus Protein Transport Establishment Of Protein Localization Cellular Localization Intracellular Transport Establishment Of Localization In Cell Golgi Vesicle Transport Intracellular Protein Transport Membrane Coat Golgi Membrane Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Trans-Golgi Network Membrane Melanosome Assembly Localization Within Membrane Platelet Dense Granule Organization Post-Golgi Vesicle-mediated Transport Vesicle Cargo Loading COPI Vesicle Coat COPI-coated Vesicle Melanosome Organization Pigment Granule Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Protein Localization To Membrane Golgi To Vacuole Transport Early Endosome Transport Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Trans-Golgi Network Secretory Granule Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Localization To Cell Surface Intra-Golgi Vesicle-mediated Transport Organelle Organization Vesicle Organization Clathrin-coated Vesicle Membrane Synaptic Vesicle Transport Vesicle Coating AP-3 Adaptor Complex Protein Localization To Cell Periphery Endocytosis Clathrin Adaptor Complex Organelle Transport Along Microtubule Cytosol Synaptic Vesicle Budding From Endosome Vacuolar Transport	Mitotic Cytokinetic Process Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Cleavage Furrow Ingression Membrane Invagination Regulation Of Supramolecular Fiber Organization Cytokinetic Process Mitotic Cleavage Furrow Ingression Aortic Valve Formation Regulation Of Endothelial Cell Migration Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Lymphocyte Migration Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Positive Regulation Of Lymphocyte Migration Skeletal Muscle Satellite Cell Migration Neurotransmitter Receptor Regulator Activity Positive Regulation Of B Cell Chemotaxis Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Response To Wortmannin Bronchus Morphogenesis Ciliary Base Mitotic Spindle Organization Positive Regulation Of Mononuclear Cell Migration Focal Adhesion Beta Selection Intraciliary Transport Particle A Binding