ARF1 and ASAP1

Number of citations of the paper that reports this interaction (PubMedID 16332543)
0

Data Source:
BioGRID (enzymatic study, imaging technique)
HPRD (in vitro, in vivo)

		ARF1	ASAP1
Description		ARF GTPase 1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endomembrane System Postsynaptic Density Membrane Sarcomere Cell Leading Edge Protein-containing Complex Neuron Projection Synapse Extracellular Exosome	Golgi Membrane Podosome Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Trans-Golgi Network Membrane Centriolar Satellite
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Cadherin Binding Metal Ion Binding
	Biological Process	Regulation Of Receptor Internalization Intracellular Copper Ion Homeostasis Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Long-term Synaptic Depression Dendritic Spine Organization Cellular Response To Virus Mitotic Cleavage Furrow Ingression	Cell Projection Organization Cilium Assembly Protein Localization To Cilium Positive Regulation Of Membrane Tubulation
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Glycosphingolipid transport	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs		1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Chlortetracycline Glycerin
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091)	Appendicular lean mass ( 33097823) Diisocyanate-induced asthma ( 25918132) HDL cholesterol levels in HIV infection ( 33109212) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Multiple sclerosis ( 19525955) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 27863252) Platelet distribution width ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Progressive supranuclear palsy ( 30089514) Refractive error ( 32231278) Sleep duration (> 10 hours) ( 33075057) Tuberculosis ( 25774636) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		50 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DENND1A DENND1B DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 SNCA TMED10 TMED2 TMEM106A WBP11	15 interacting genes: ARF1 ARF6 CBL CRK DNAJB6 GRB2 HCK PACSIN3 PTK2 PTK2B PXN RAB11FIP3 REPS2 SH3KBP1 SRC
Entrez ID		375	50807
HPRD ID		00054	05809
Ensembl ID		ENSG00000143761	ENSG00000153317
Uniprot IDs		P84077	A0A0A0MRE5 Q9ULH1
PDB IDs		1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE 7DN8 7DN9 7MGE 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9U 8D9W 8SDW 9C58 9C59 9C5A 9C5B	2D1X 2DA0 2ED1 2RQT 2RQU
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Intracellular Protein Localization Golgi Apparatus Protein Transport Establishment Of Protein Localization Cellular Localization Intracellular Transport Establishment Of Localization In Cell Golgi Vesicle Transport Intracellular Protein Transport Membrane Coat Golgi Membrane Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Trans-Golgi Network Membrane Melanosome Assembly Localization Within Membrane Platelet Dense Granule Organization Post-Golgi Vesicle-mediated Transport Vesicle Cargo Loading COPI Vesicle Coat COPI-coated Vesicle Melanosome Organization Pigment Granule Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Protein Localization To Membrane Golgi To Vacuole Transport Early Endosome Transport Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Trans-Golgi Network Secretory Granule Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Localization To Cell Surface Intra-Golgi Vesicle-mediated Transport Organelle Organization Vesicle Organization Clathrin-coated Vesicle Membrane Synaptic Vesicle Transport Vesicle Coating AP-3 Adaptor Complex Protein Localization To Cell Periphery Endocytosis Clathrin Adaptor Complex Organelle Transport Along Microtubule Cytosol Synaptic Vesicle Budding From Endosome Vacuolar Transport	Focal Adhesion Signal Complex Assembly Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization ERBB Signaling Pathway Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Binding Regulation Of Actin Filament-based Process Enzyme-linked Receptor Protein Signaling Pathway Cytosol Regulation Of Cell Morphogenesis Endocytosis Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Actin Filament Organization Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Vesicle-mediated Transport Plasma Membrane Positive Regulation Of Organelle Organization Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Component Biogenesis Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Import Into Cell Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Immune Effector Process Anchoring Junction Positive Regulation Of Protein Polymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Cytoplasm Positive Regulation Of Cellular Component Organization Integrin-mediated Signaling Pathway Protein Localization To Cleavage Furrow SH3 Domain Binding Cellular Response To Fluid Shear Stress Protein Autophosphorylation Fc-gamma Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity
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