MAGED1 and SIM2

Number of citations of the paper that reports this interaction (PubMedID 27472814)
0

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		MAGED1	SIM2
Description		MAGE family member D1	SIM bHLH transcription factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Protein-containing Complex	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Transcription Coactivator Activity Protein Binding Identical Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Protein Localization To Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Embryonic Pattern Specification Cell Differentiation Lung Development Negative Regulation Of DNA-templated Transcription System Development
Pathways		NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases
GWAS		Bell's palsy ( 33602968)	Appendicular lean mass ( 33097823) Asthma and hay fever ( 24388013) Cerebellum cortex volume ( 31530798) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Night sleep phenotypes ( 27126917) Red blood cell count ( 27863252)
Interacting Genes		128 interacting genes: AGRN AKAP9 ARHGEF16 ARID5A ARNT2 BAG3 BAG4 BARD1 BHLHE40 BIRC8 BRCA2 C1orf94 CA8 CAPN7 CCDC120 CCDC33 CDC23 CERCAM CFAP206 CHERP DAB1 DAZAP2 DDX6 DLX4 DLX5 DMRT2 EIF3J EIF4E2 EP300 ERCC3 FAM83A FOXD2 FOXH1 FOXI1 FXR1 FXR2 GATA5 GLRA1 GLYCTK GPANK1 GPR135 GRAP2 HEMK1 HGS HIVEP1 HNRNPH1 HNRNPLL HOXC9 HSF2BP HUNK KPNA2 KPNA6 KRTAP19-5 KRTAP6-1 KRTAP6-3 LARP4B LENG8 LONRF1 MAPK1IP1L MAPK3 MDFI MEOX2 MGAT5B MKRN3 MPC1 MSX2 NAF1 NGFR NOTCH1 NOTO NPAS4 NUMBL PHF1 PITX1 PJA1 PJA2 PLK1 PNMA5 POM121 PRKAB2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSMF1 RAMAC RBFOX1 RBFOX2 RBM23 RBPMS RBPMS2 RFX1 RHOXF2 RNF6 RNF8 ROR2 RUSC1 RXFP4 SIM2 SIRT7 SMAP2 SMN1 SMN2 SNRPC SOX10 SOX5 TBX6 TFG TIAL1 TLX3 TRAF4 TRIM28 TSGA10IP TTC23 TTC32 TUBA4A UNC5A VASP VENTX XIAP YTHDF1 ZFYVE26 ZIC1 ZNF488 ZNF688	9 interacting genes: ADD3 ARNT EPS15L1 MAGED1 PAX6 PPP5C PREX1 PRKN PTGES3
Entrez ID		9500	6493
HPRD ID		02202	02935
Ensembl ID		ENSG00000179222	ENSG00000159263
Uniprot IDs		Q9Y5V3	Q14190
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Cytoplasmic Stress Granule Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process System Development Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Nucleic Acid Binding Nervous System Development Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Pattern Specification Process Embryonic Morphogenesis MRNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Identical Protein Binding Negative Regulation Of RNA Metabolic Process Cytoplasmic Ribonucleoprotein Granule Nuclear Androgen Receptor Binding RNA Binding Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Protein Import Into Nucleus Regulation Of Nucleocytoplasmic Transport Viral Penetration Into Host Nucleus Regulation Of RNA Splicing Transcription Regulator Complex	Cytoplasm Response To Oxidative Stress Protein-containing Complex Embryonic Camera-type Eye Morphogenesis Embryonic Eye Morphogenesis Protein Serine/threonine Kinase Inhibitor Activity Cellular Response To Oxidative Stress Positive Regulation Of ATP Metabolic Process Protein Folding Chaperone Complex Hsp90 Protein Binding Lens Development In Camera-type Eye Protein Stabilization Hsp70 Protein Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization System Process Cytosol Regulation Of Epithelial Cell Proliferation Nuclear Aryl Hydrocarbon Receptor Complex Regulation Of ATP Metabolic Process Cellular Response To Chemical Stress Regulation Of Purine Nucleotide Metabolic Process Eye Morphogenesis Sensory Organ Morphogenesis Response To Hydrogen Peroxide Regulation Of Protein Stability Camera-type Eye Development Protein-folding Chaperone Binding Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Heat Shock Protein Binding Response To Curcumin Protein Polymerization Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Habenula Development Pallium Development Response To Arachidonate
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