MAGED1 and SIRT7

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MAGED1	SIRT7
Gene Name		melanoma antigen family D, 1	sirtuin 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Plasma Membrane Protein Complex	Nucleus Nucleolus Nucleolus Organizer Region Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding	Chromatin Binding Protein Binding Metal Ion Binding NAD+ Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription On Exit From Mitosis RRNA Transcription Histone H3 Deacetylation Histone H4 Deacetylation
Pathways		Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE NRAGE signals death through JNK Programmed Cell Death p75 NTR receptor-mediated signalling Role of DCC in regulating apoptosis Extrinsic Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		49 interactors: AKAP9 BAG3 BHLHE40 BIRC8 BRCA2 C1orf94 CA8 CCDC33 DAB1 DLX4 DLX5 EIF3J EIF4E2 EP300 GPR135 HIVEP1 KPNA2 KRTAP19-5 MAPK3 MDFI MEOX2 MPC1 MSX2 NGFR NUMBL PITX1 PJA1 PJA2 PLK1 PRKAB2 RBFOX1 RBFOX2 RBM23 RBPMS RFX1 RHOXF2 ROR2 SIRT7 SMAP2 SNRPC TFG TRAF4 TRIM28 TTC23 TTC32 TUBA4A UNC5A XIAP ZNF488	6 interactors: APP HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE MAGED1
Entrez ID		9500	51547
HPRD ID		02202	12094
Ensembl ID		ENSG00000179222	ENSG00000187531
Uniprot IDs		Q9Y5V3	Q9NRC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Binding Transcription, DNA-templated Metabolic Process Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Cellular Response To Stimulus Positive Regulation Of Signal Transduction RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cell Death Death Regulation Of Protein Metabolic Process Multicellular Organismal Development Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Signaling Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Embryo Development Radial Glia Guided Migration Of Purkinje Cell Cellular Process Macromolecule Biosynthetic Process Apoptotic Signaling Pathway Cell Morphogenesis Involved In Differentiation Cell Communication Positive Regulation Of Metabolic Process System Development Apoptotic Process Response To Stimulus	DNA Replication-dependent Nucleosome Assembly Nucleosome Assembly Chromatin Assembly DNA Methylation On Cytosine Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Silencing At RDNA Protein-DNA Complex Assembly DNA Packaging Chromatin Silencing DNA Conformation Change DNA Methylation Negative Regulation Of Gene Expression, Epigenetic DNA Modification Gene Silencing Cellular Macromolecular Complex Assembly Synaptic Growth At Neuromuscular Junction Chromatin Organization Cellular Component Assembly Collateral Sprouting In Absence Of Injury Histone H4-K20 Demethylation Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Chromosome Organization Protein Complex Assembly Axon Choice Point Recognition Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Neuron Remodeling Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Methylation Innate Immune Response In Mucosa Blood Coagulation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Cellular Copper Ion Homeostasis Hemostasis Regulation Of Megakaryocyte Differentiation Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Gene Silencing Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle CENP-A Containing Nucleosome Assembly
Tagcloud ?		allelic analytical coexpression coordinator datasets esrp2 exemplifies fgfr2 gbp1 glud2 illustrates impairs indels landscape mad2l1bp mtap overlaid principle proof r353q revealing signatures slc30a8 splicing substitution tbnc tnbc tpp1 transcriptome	advanced aimed altered biomarkers carcinoma circulating family head healthy hnscc individuals leukocytes markers neck pb peripheral possibility postoperative profiles prognostic recovery regulated sirt1 sirt3 sirt6 squamous stage surgery
Tagcloud (Difference) ?		allelic analytical coexpression coordinator datasets esrp2 exemplifies fgfr2 gbp1 glud2 illustrates impairs indels landscape mad2l1bp mtap overlaid principle proof r353q revealing signatures slc30a8 splicing substitution tbnc tnbc tpp1 transcriptome	advanced aimed altered biomarkers carcinoma circulating family head healthy hnscc individuals leukocytes markers neck pb peripheral possibility postoperative profiles prognostic recovery regulated sirt1 sirt3 sirt6 squamous stage surgery
Tagcloud (Intersection) ?