RPN2 and RCHY1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RPN2	RCHY1
Description		ribophorin II	ring finger and CHY zinc finger domain containing 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Nuclear Body Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Protein Modification Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Error-free Translesion Synthesis Rescue Of Stalled Ribosome
Pathways		SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane	Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 31562340) Hippocampal atrophy ( 19668339) Initial pursuit acceleration in psychotic disorders ( 29064472) Kawasaki disease ( 33692975)	Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Interacting Genes		17 interacting genes: ADRM1 BCL2L13 EZH2 FBN3 ISG15 LINC00632 LTB4R2 NDRG1 NGFR PDE4B PTEN RBBP4 RCHY1 RHOA SLC22A2 SMO WEE2-AS1	74 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 AXIN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160
Entrez ID		6185	25898
HPRD ID		01609	07607
Ensembl ID		ENSG00000118705	ENSG00000163743
Uniprot IDs		P04844	Q96PM5
PDB IDs		6S7O 6S7T 8B6L 8PN9	2JRJ 2K2C 2K2D 7YNX
Enriched GO Terms of Interacting Partners?		Dendritic Spine Negative Regulation Of Hair Follicle Development Regulation Of Protein Modification Process Negative Regulation Of Cell Size Forebrain Morphogenesis ESC/E(Z) Complex Myelin Maintenance Odontogenesis Negative Regulation Of Cell Migration Animal Organ Development Regulation Of Cell Migration Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Motility Regulation Of Cell Motility Negative Regulation Of Cell Communication Regulation Of Hair Cycle Regulation Of Hair Follicle Development Dentate Gyrus Development Negative Regulation Of Locomotion Regulation Of Locomotion Central Nervous System Development Hair Follicle Morphogenesis Molecular Function Inhibitor Activity Regulation Of Protein Phosphorylation Gamma-tubulin Binding Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of Kidney Development Negative Regulation Of Multicellular Organismal Process Regulation Of Phosphorylation Regulation Of Cell Development Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Hepatocyte Homeostasis Homeostasis Of Number Of Cells Hair Follicle Development Negative Regulation Of Synaptic Vesicle Clustering Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Ventral Midline Determination Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorus Metabolic Process Rho Protein Signal Transduction Cellular Response To Oxygen-containing Compound Negative Regulation Of Cell-substrate Adhesion Aortic Valve Formation Regulation Of Focal Adhesion Assembly	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Skeletal System Morphogenesis Regionalization Anterior/posterior Pattern Specification Skeletal System Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Organ Morphogenesis Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Embryonic Morphogenesis Chromatin Positive Regulation Of Biosynthetic Process Rhombomere Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Localization To Plasma Membrane P53 Binding MDM2/MDM4 Family Protein Binding Skeletal System Development Regulation Of Macromolecule Biosynthetic Process Rhombomere 4 Development Developmental Process Nucleus Nucleoplasm Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Rhombomere 3 Development Regulation Of Protein Localization To Cell Periphery Animal Organ Morphogenesis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?