RPN2 and ADRM1

Number of citations of the paper that reports this interaction (PubMedID 16990800)
36

Data Source:
HPRD (in vitro)

		RPN2	ADRM1
Description		ribophorin II	ADRM1 26S proteasome ubiquitin receptor
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Nuclear Body Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Proteasome Regulatory Particle, Lid Subcomplex
	Molecular Function	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding	Protease Binding Protein Binding Endopeptidase Activator Activity Proteasome Binding Molecular Function Inhibitor Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Protein Modification Process	Transcription Elongation By RNA Polymerase II Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasome Assembly
Pathways		SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 31562340) Hippocampal atrophy ( 19668339) Initial pursuit acceleration in psychotic disorders ( 29064472) Kawasaki disease ( 33692975)	Prostate cancer ( 23535732)
Interacting Genes		17 interacting genes: ADRM1 BCL2L13 EZH2 FBN3 ISG15 LINC00632 LTB4R2 NDRG1 NGFR PDE4B PTEN RBBP4 RCHY1 RHOA SLC22A2 SMO WEE2-AS1	23 interacting genes: APP ATP6V0D2 CDC42 DDI1 EGFR MAILR MX1 PRKN PSMD1 PSMD14 PSMD2 PSMD4 RAD23A RAD23B RPN1 RPN2 SGTA SMURF1 STUB1 UBE3A UBQLN1 UBQLN2 UCHL5
Entrez ID		6185	11047
HPRD ID		01609	06440
Ensembl ID		ENSG00000118705	ENSG00000130706
Uniprot IDs		P04844	A0A087WX59 Q16186
PDB IDs		6S7O 6S7T 8B6L 8PN9	2KQZ 2KR0 2L5V 2MKZ 2NBV 4UEL 4UEM 4WLQ 4WLR 5IRS 5V1Y 5V1Z 5YMY 6CO4 6OI4 6UYI 6UYJ 7KXI 8FTQ
Enriched GO Terms of Interacting Partners?		Dendritic Spine Negative Regulation Of Hair Follicle Development Regulation Of Protein Modification Process Negative Regulation Of Cell Size Forebrain Morphogenesis ESC/E(Z) Complex Myelin Maintenance Odontogenesis Negative Regulation Of Cell Migration Animal Organ Development Regulation Of Cell Migration Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Motility Regulation Of Cell Motility Negative Regulation Of Cell Communication Regulation Of Hair Cycle Regulation Of Hair Follicle Development Dentate Gyrus Development Negative Regulation Of Locomotion Regulation Of Locomotion Central Nervous System Development Hair Follicle Morphogenesis Molecular Function Inhibitor Activity Regulation Of Protein Phosphorylation Gamma-tubulin Binding Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of Kidney Development Negative Regulation Of Multicellular Organismal Process Regulation Of Phosphorylation Regulation Of Cell Development Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Hepatocyte Homeostasis Homeostasis Of Number Of Cells Hair Follicle Development Negative Regulation Of Synaptic Vesicle Clustering Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation Ventral Midline Determination Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorus Metabolic Process Rho Protein Signal Transduction Cellular Response To Oxygen-containing Compound Negative Regulation Of Cell-substrate Adhesion Aortic Valve Formation Regulation Of Focal Adhesion Assembly	Proteasomal Protein Catabolic Process Proteasome Complex Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Catabolic Process Regulation Of Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Regulation Of Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Proteasome Accessory Complex Positive Regulation Of Proteasomal Protein Catabolic Process Proteasome Binding Positive Regulation Of ERAD Pathway Positive Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Protein Metabolic Process ERAD Pathway Kinase Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Catabolic Process Proteasome Regulatory Particle, Base Subcomplex Cytosol Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome Storage Granule Regulation Of Macroautophagy Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Post-translational Protein Modification Oligosaccharyltransferase Complex B Positive Regulation Of Cell Growth Cellular Response To Manganese Ion Oligosaccharyltransferase Complex A Ubiquitin Protein Ligase Activity
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