NTF4 and NTRK2

Number of citations of the paper that reports this interaction (PMID 11855816)
0

Data Source:
HPRD (in vivo)

		NTF4	NTRK2
Gene Name		neurotrophin 4	neurotrophic tyrosine kinase, receptor, type 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Cytoplasmic Membrane-bounded Vesicle	Rough Endoplasmic Reticulum Cytosol Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Growth Cone Terminal Bouton Dendritic Spine Perikaryon Receptor Complex Postsynaptic Membrane Presynaptic Active Zone Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Neurotrophin P75 Receptor Binding Growth Factor Activity	ATP Binding Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor-activated Receptor Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Ganglion Mother Cell Fate Determination Long-term Memory Sensory Organ Boundary Specification Adult Locomotory Behavior Epidermis Development Mechanoreceptor Differentiation Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Innervation Taste Bud Development	Vasculogenesis Neuron Migration Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Neuromuscular Junction Development Aging Learning Long-term Memory Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Proliferation Response To Light Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Glutamate Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Development Cerebral Cortex Development Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Rac GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Mechanoreceptor Differentiation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Dendrite Development Regulation Of Protein Kinase B Signaling Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Anoikis
Pathways			Signalling by NGF Activation of TRKA receptors NGF-independant TRKA activation NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS			Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		4 interactors: ADAMTSL4 CLIC1 NGFR NTRK2	29 interactors: AP1B1 BDNF DOK5 DYNLL1 FRS2 FRS3 FYN GIPC1 KIDINS220 NCK1 NCK2 NGFR NMNAT1 NTF3 NTF4 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB
Entrez ID		4909	4915
HPRD ID		01220	02712
Ensembl ID		ENSG00000225950	ENSG00000148053
Uniprot IDs		P34130	Q16620 Q548C2 Q5VWE5
PDB IDs		1B8M 1B98 1HCF	1HCF 1WWB 4ASZ 4AT3 4AT4 4AT5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Axonogenesis Positive Regulation Of Cell Differentiation Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Circadian Rhythm Negative Regulation Of Hair Follicle Development Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Neurotrophin Signaling Pathway Brain-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Cell Projection Organization Regulation Of Apoptotic Process Rhythmic Process Regulation Of Cell Death Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Neuron Projection Development Positive Regulation Of Neurogenesis Protein O-linked Fucosylation Positive Regulation Of Odontogenesis Retinal Rod Cell Development Peripheral Nervous System Neuron Development Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Negative Regulation Of Anoikis Positive Regulation Of Cell Development Regulation Of Odontogenesis Of Dentin-containing Tooth Membrane Protein Intracellular Domain Proteolysis Regulation Of Hair Follicle Development Regulation Of Anoikis Regulation Of Neuron Differentiation Response To Auditory Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death Response To Growth Factor Regulation Of Hair Cycle Regulation Of Rac GTPase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cell Death Glutamate Secretion Cellular Response To Nerve Growth Factor Stimulus Anion Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Detection Of Temperature Stimulus	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Regulation Of Phosphorylation Cellular Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Nervous System Development Insulin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Intracellular Signal Transduction Response To Stimulus Cellular Response To Peptide Hormone Stimulus Neuron Projection Development Cellular Response To Peptide Cellular Response To Organonitrogen Compound Neuron Projection Morphogenesis Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cell Projection Organization Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Activation Of MAPK Activity Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Response To Organic Substance
Tagcloud ?		actin contain cytosolic exclusively filament fractionation germination kim map mature motif mutagenesis ntmek2 ntprof2 p45 pellet phosphorylate pollen predominantly profilin profilins residue sipk speed substrates thought threonine tobacco tube	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		actin contain cytosolic exclusively filament fractionation germination kim map mature motif mutagenesis ntmek2 ntprof2 p45 pellet phosphorylate pollen predominantly profilin profilins residue sipk speed substrates thought threonine tobacco tube	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?