EGR1 and CEBPB

Number of citations of the paper that reports this interaction (PMID 12947119)
14

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EGR1	CEBPB
Gene Name		early growth response 1	CCAAT/enhancer binding protein (C/EBP), beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Condensed Chromosome, Centromeric Region Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Glucocorticoid Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Amphetamine Transcription From RNA Polymerase II Promoter Learning Or Memory Circadian Rhythm Response To Glucose Cytokine-mediated Signaling Pathway T Cell Differentiation BMP Signaling Pathway Response To Nutrient Levels Cellular Response To Insulin Stimulus Regulation Of Protein Sumoylation Response To Carbon Monoxide Cellular Response To Drug Skeletal Muscle Cell Differentiation Response To Cocaine Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Long-term Neuronal Synaptic Plasticity Oligodendrocyte Differentiation Response To Electrical Stimulus Long-term Synaptic Potentiation Type I Interferon Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Antibiotic Cellular Response To Mechanical Stimulus Cellular Response To Isoquinoline Alkaloid Cellular Response To CAMP Cellular Response To Growth Factor Stimulus Cellular Response To Gonadotropin Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Hyperoxia Cellular Response To Hypoxia Cellular Response To Gamma Radiation Cellular Response To Heparin Cellular Response To Mycophenolic Acid Response To Norepinephrine Glomerular Mesangial Cell Proliferation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Embryonic Placenta Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Acute-phase Response Inflammatory Response Immune Response Neuron Differentiation Response To Lipopolysaccharide Mammary Gland Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress Negative Regulation Of Neuron Apoptotic Process Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Brown Fat Cell Differentiation Mammary Gland Epithelial Cell Differentiation Regulation Of Transcription Involved In Cell Fate Commitment Cellular Response To Amino Acid Stimulus
Pathways		Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Transcriptional regulation of white adipocyte differentiation Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		20 interactors: CDKN2A CEBPB CREBBP CSNK2A1 EP300 ERBB3 IL1B JUN NAB1 NAB2 NFATC1 NFATC2 PITX1 PSMA3 RELA SP1 SRA1 SREBF2 TP53 WT1	54 interactors: AR ATF2 ATF4 CAMK2A CCL3 CEBPA CEBPD CEBPG CREB1 CREBBP DDIT3 EGFR EGR1 ELK1 EP300 ESR1 FOXO1 HMGA1 HMGB1 HNRNPK HOMER3 HSF1 KAT2A KAT2B MAPK1 MAPK3 MED23 MYB MYC NCOR2 NFKB1 NOLC1 NR3C1 PTGES2 RARB RB1 RELA RPS6KA1 RPS6KA5 RUNX1 RUNX2 SMAD3 SMAD4 SMARCA4 SMARCB1 SMARCC1 SP1 SPI1 SPIB SRF STAT5A STAT6 TAF9 TRIM28
Entrez ID		1958	1051
HPRD ID		00549	01801
Ensembl ID		ENSG00000120738	ENSG00000172216
Uniprot IDs		P18146 Q546S1	P17676
PDB IDs			1GTW 1GU4 1GU5 1H88 1H89 1H8A 1HJB 1IO4 2E42 2E43
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Apoptotic Process Cell Differentiation Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Developmental Process Negative Regulation Of Apoptotic Process Immune System Process Negative Regulation Of Programmed Cell Death Immune Response Negative Regulation Of Cell Death Cellular Metabolic Process Positive Regulation By Host Of Viral Transcription Anatomical Structure Morphogenesis	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression DNA-templated Transcription, Initiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune System Process Cellular Metabolic Process System Development Developmental Process Gland Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Anatomical Structure Development Organ Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus
Tagcloud ?		acidic acts astrocyte astrocytes astrocytosis capable cascade controlling decreases exhibits fibrillary gfap glial hiv immunodeficiency importantly indirect nervous neurological neurotoxicity pathogenic roles sequential stat3 tat transactivation transducer upstream	activates anticancer atf4 attenuated autophagy chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Difference) ?		acidic acts astrocyte astrocytes astrocytosis capable cascade controlling decreases exhibits fibrillary gfap glial hiv immunodeficiency importantly indirect nervous neurological neurotoxicity pathogenic roles sequential stat3 tat transactivation transducer upstream	activates anticancer atf4 attenuated autophagy chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Intersection) ?