EGR1 and NFATC1

Number of citations of the paper that reports this interaction (PubMedID 12560487)
56

Data Source:
BioGRID (pull down)

		EGR1	NFATC1
Description		early growth response 1	nuclear factor of activated T cells 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Enzyme Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding FK506 Binding Protein Phosphatase 2B Binding Mitogen-activated Protein Kinase P38 Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Response To Ischemia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Glucose Positive Regulation Of Gene Expression T Cell Differentiation BMP Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Protein Sumoylation Skeletal Muscle Cell Differentiation Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Estrous Cycle Locomotor Rhythm Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Biosynthetic Process Rhythmic Process Circadian Temperature Homeostasis Interleukin-1-mediated Signaling Pathway Cellular Response To Gamma Radiation Cellular Response To Heparin Cellular Response To Mycophenolic Acid Glomerular Mesangial Cell Proliferation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Interleukin-8 Positive Regulation Of Post-translational Protein Modification Positive Regulation Of MiRNA Transcription Regulation Of Progesterone Biosynthetic Process	Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Regulation Of DNA-templated Transcription Negative Regulation Of Wnt Signaling Pathway Calcineurin-NFAT Signaling Cascade Intracellular Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription NGF-stimulated transcription Interferon alpha/beta signaling	Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs			Pseudoephedrine
Diseases
GWAS		Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Autism spectrum disorder or schizophrenia ( 28540026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 25056061 28991256)	Appendicular lean mass ( 33097823) Blood urea nitrogen levels ( 31152163 29403010) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic kidney disease ( 31152163 29124443) Creatinine levels ( 29124443 31015462 29403010) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 29124443 31015462 31152163 31451708 29779033 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling hurt ( 29500382) Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Glomerular filtration rate ( 29403010 27588450) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Hyperuricemia ( 29124443) Inflammatory bowel disease ( 26192919) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Medication use (thyroid preparations) ( 31015401) Neonatal white matter microstructure ( 33009551) Neutrophil percentage of white cells ( 32888494) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Serum creatinine levels ( 29779033) Waist circumference adjusted for body mass index ( 34021172) Working memory ( 31598132)
Interacting Genes		27 interacting genes: CDKN2A CEBPB CRBN CREBBP CSNK2A1 DNMT3L EP300 ERBB3 IL1B JUN MTDH NAB1 NAB2 NEAT1 NEDD4 NFATC1 NFATC2 NGFR PITX1 PSMA3 RELA SNCA SP1 SRA1 SREBF2 TP53 WT1	16 interacting genes: EGR1 EGR2 EP300 HDAC5 KAT2B KPNB1 MAPK14 PARP1 PIAS1 PIM1 PPP3R1 PRKCA RACK1 SPI1 TUBA1A YWHAQ
Entrez ID		1958	4772
HPRD ID		00549	02729
Ensembl ID		ENSG00000120738	ENSG00000131196
Uniprot IDs		P18146 Q546S1	A8K9C6 B4DER8 F5H4S8 O95644
PDB IDs		4R2A 4R2C 4R2D 4X9J 5N14	1A66 1NFA 5SVE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Positive Regulation Of MiRNA Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Intracellular Signaling Cassette Transcription Regulator Complex Regulation Of Developmental Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Signal Transduction Chromatin DNA-binding Transcription Factor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Schwann Cell Differentiation NF-kappaB Binding Cellular Response To Stress Regulation Of Signal Transduction	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Enzyme Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Gene Expression, Epigenetic Response To Peptide Hormone Response To Insulin Cellular Response To Oxygen-containing Compound Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA-binding Transcription Factor Binding Programmed Cell Death Response To Hormone Positive Regulation Of Developmental Process Cell Death RNA Polymerase II-specific DNA-binding Transcription Factor Binding Leukocyte Differentiation Regulation Of Developmental Process Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization Response To Radiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process N-terminal Peptidyl-lysine Acetylation Regulation Of Cell Differentiation Protein-containing Complex Positive Regulation Of Intracellular Signal Transduction Chromatin Binding Transcription Cis-regulatory Region Binding Nucleus Negative Regulation Of Metabolic Process
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