CAPN2 and TNS1

Number of citations: 43 (PubMedID 11023826)
Data Source: HPRD (in vivo, in vitro)

		CAPN2	TNS1
Name		calpain 2	tensin 1
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Dendrite Cortical Actin Cytoskeleton Pseudopodium Cell Projection Neuronal Cell Body Membrane Raft Extracellular Exosome Perinuclear Endoplasmic Reticulum Presynapse Postsynapse Calpain Complex	Cytoplasm Cytoskeleton Focal Adhesion Cell Surface Cell-substrate Junction Anchoring Junction
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Enzyme Binding Protein-containing Complex Binding Metal Ion Binding	RNA Binding Actin Binding Phosphoprotein Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Response To Hypoxia Blastocyst Development Proteolysis Myoblast Fusion Female Pregnancy Response To Mechanical Stimulus Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Autoprocessing Protein Catabolic Process Regulation Of Interleukin-6 Production Cellular Response To Interferon-beta Response To Hydrogen Peroxide Behavioral Response To Pain Synaptic Vesicle Endocytosis Regulation Of Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Protein Catabolic Process At Postsynapse Positive Regulation Of Myoblast Fusion Positive Regulation Of Phosphatidylcholine Biosynthetic Process	Cell-substrate Junction Assembly Fibroblast Migration
Pathways		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	None
GWAS		Blood protein levels ( 30072576 ) Carotenoid levels (alpha-carotene) ( 28002826 ) Febrile seizures (MMR vaccine-related) ( 25344690 ) Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) ( 33208821 ) Waist circumference ( 31170924 )	Age-related cognitive decline (language) (slope of z-scores) ( 30954325 ) Asthma and hay fever ( 24388013 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Chronic obstructive pulmonary disease ( 33909500 30804561 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Coronary artery disease ( 33020668 29212778 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Diastolic blood pressure ( 27841878 28135244 ) Diverticular disease ( 30177863 ) FEV1 ( 30804560 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) HDL cholesterol levels in HIV infection ( 33109212 ) Height ( 20881960 28552196 25429064 25282103 21998595 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Intraocular pressure ( 30054594 29785010 29617998 29235454 ) Lung function (FEV1) ( 28166213 ) Lung function (FEV1/FVC) ( 30804560 28166213 ) Lung function (FVC) ( 30804560 28166213 ) Lung function (low FEV1 vs high FEV1) ( 26423011 ) Mitral valve prolapse ( 26301497 ) Myocardial infarction ( 33532862 ) Pulmonary function ( 20010834 ) Pulmonary function (smoking interaction) ( 23284291 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Systolic blood pressure ( 27841878 30578418 )
Novel Interactors		1 novel interactors: TUBA4A	None recorded
Interacting Genes		23 interacting genes: ATG5 ATXN3 BCL2 BID CAPNS1 CAPNS2 CASP9 CDK5R1 DUX4 F2RL1 GAS2 GRK2 KCTD7 KNG1 MAPK1 MTDH NFKBIA NMT1 PBXIP1 PTPN1 PTPRN TNS1 ZFYVE21	16 interacting genes: AR CAPN2 EGFR ERBB2 ERBB3 ERBB4 FRS3 GAB1 KIT KLF10 MET OSGEP PPP1CC PTK2 RNF10 YWHAZ
Entrez ID		824	7145
HPRD ID		00254	02512
Ensembl ID		ENSG00000162909	ENSG00000079308
Uniprot IDs		B4DN77 P17655 Q59EF6	A0A2R8Y4T1 A1L0S7 B2RU35 B7Z6H8 E9PF55 E9PGF5 Q0VG54 Q0VG55 Q59G71 Q86VB0 Q9HBL0
PDB IDs		1KFU 1KFX 2NQA	Not available
GO Terms Enriched among Interactors		Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Epithelial Cell Apoptotic Process Response To Nutrient Levels Positive Regulation Of Programmed Cell Death Cellular Response To Nutrient Levels Calpain Complex Lipopolysaccharide-mediated Signaling Pathway Regulation Of Signal Transduction B Cell Receptor Signaling Pathway Vasodilation Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium-dependent Cysteine-type Endopeptidase Activity Cellular Response To Starvation Regulation Of Autophagy Apoptotic Process Programmed Cell Death Cell Death Regulation Of Cell Population Proliferation Response To Starvation Pseudopodium Viral Genome Replication Regulation Of Biological Quality G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Peptidyl-threonine Phosphorylation Neuron Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Protease Binding Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Cellular Localization Cellular Response To Topologically Incorrect Protein Regulation Of Establishment Of Protein Localization Protein Phosphatase 2A Binding Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Iron Ion NF-kappaB Binding Regulation Of Transport Cellular Response To Stress Regulation Of Intracellular Signal Transduction Stem Cell Development	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Developmental Process Basal Plasma Membrane ERBB2 Signaling Pathway Receptor Complex Protein Phosphatase Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Programmed Cell Death Protein Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Neuron Differentiation Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Kinase Activity Positive Regulation Of Epithelial Cell Proliferation ERBB3:ERBB2 Complex Regulation Of MAPK Cascade Animal Organ Development Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Apoptotic Process Transferase Activity Regulation Of Phosphorus Metabolic Process Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Regulation Of Apoptotic Process Regulation Of Epithelial Cell Proliferation