CAPN2 and CAPNS2

Number of citations of the paper that reports this interaction (PubMedID 11853546)
28

Data Source:
HPRD (in vitro)

		CAPN2	CAPNS2
Description		calpain 2	calpain small subunit 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Dendrite Cortical Actin Cytoskeleton Pseudopodium Cell Projection Neuronal Cell Body Membrane Raft Extracellular Exosome Perinuclear Endoplasmic Reticulum Presynapse Postsynapse Calpain Complex	Cytoplasm Cytosol Plasma Membrane Membrane Calpain Complex
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Enzyme Binding Protein-containing Complex Binding Metal Ion Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Blastocyst Development Proteolysis Myoblast Fusion Female Pregnancy Response To Mechanical Stimulus Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Autoprocessing Protein Catabolic Process Regulation Of Interleukin-6 Production Cellular Response To Interferon-beta Response To Hydrogen Peroxide Behavioral Response To Pain Synaptic Vesicle Endocytosis Regulation Of Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Protein Catabolic Process At Postsynapse Positive Regulation Of Myoblast Fusion Positive Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Carotenoid levels (alpha-carotene) ( 28002826) Febrile seizures (MMR vaccine-related) ( 25344690) Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) ( 33208821) Waist circumference ( 31170924)	Thyroid hormone levels ( 23408906)
Interacting Genes		23 interacting genes: ATG5 ATXN3 BCL2 BID CAPNS1 CAPNS2 CASP9 CDK5R1 DUX4 F2RL1 GAS2 GRK2 KCTD7 KNG1 MAPK1 MTDH NFKBIA NMT1 PBXIP1 PTPN1 PTPRN TNS1 ZFYVE21	9 interacting genes: APP ARMC10 CAPN2 CMTM5 OXNAD1 PHACTR3 PPIC PRPF31 RIN1
Entrez ID		824	84290
HPRD ID		00254	16682
Ensembl ID		ENSG00000162909	ENSG00000256812
Uniprot IDs		B4DN77 P17655 Q59EF6	Q96L46
PDB IDs		1KFU 1KFX 2NQA
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Epithelial Cell Apoptotic Process Response To Nutrient Levels Positive Regulation Of Programmed Cell Death Cellular Response To Nutrient Levels Calpain Complex Lipopolysaccharide-mediated Signaling Pathway Regulation Of Signal Transduction B Cell Receptor Signaling Pathway Vasodilation Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium-dependent Cysteine-type Endopeptidase Activity Cellular Response To Starvation Regulation Of Autophagy Apoptotic Process Programmed Cell Death Cell Death Regulation Of Cell Population Proliferation Response To Starvation Pseudopodium Viral Genome Replication Regulation Of Biological Quality G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Peptidyl-threonine Phosphorylation Neuron Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Protease Binding Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Cellular Localization Cellular Response To Topologically Incorrect Protein Regulation Of Establishment Of Protein Localization Protein Phosphatase 2A Binding Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Iron Ion NF-kappaB Binding Regulation Of Transport Cellular Response To Stress Regulation Of Intracellular Signal Transduction Stem Cell Development	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Endocytosis Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phosphatidylcholine Biosynthetic Process Calpain Complex Protein Catabolic Process At Postsynapse Regulation Of Phosphatidylcholine Biosynthetic Process Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress SnRNP Binding U4atac SnRNP Ribonucleoprotein Complex Localization SnoRNA Localization U4atac SnRNA Binding Regulation Of Growth Rate DNA Binding Domain Binding Positive Regulation Of Growth Rate Regulation Of Interleukin-6 Production Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Spliceosomal Tri-snRNP Complex Import Into Cell Axon Choice Point Recognition U4 SnRNA Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?