CAPN2 and PBXIP1

Number of citations of the paper that reports this interaction (PubMedID 25486428)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CAPN2	PBXIP1
Description		calpain 2	PBX homeobox interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Dendrite Cortical Actin Cytoskeleton Pseudopodium Cell Projection Neuronal Cell Body Membrane Raft Extracellular Exosome Perinuclear Endoplasmic Reticulum Presynapse Postsynapse Calpain Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Cytoskeleton Microtubule
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Enzyme Binding Protein-containing Complex Binding Metal Ion Binding	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Response To Hypoxia Blastocyst Development Proteolysis Myoblast Fusion Female Pregnancy Response To Mechanical Stimulus Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Autoprocessing Protein Catabolic Process Regulation Of Interleukin-6 Production Cellular Response To Interferon-beta Response To Hydrogen Peroxide Behavioral Response To Pain Synaptic Vesicle Endocytosis Regulation Of Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Protein Catabolic Process At Postsynapse Positive Regulation Of Myoblast Fusion Positive Regulation Of Phosphatidylcholine Biosynthetic Process	Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of DNA-templated Transcription Cell Adhesion Gene Expression Cell Migration Extracellular Matrix Disassembly Hemopoiesis Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Articular Cartilage Development Gene Expression Involved In Extracellular Matrix Organization Positive Regulation Of Chondrocyte Proliferation
Pathways		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Carotenoid levels (alpha-carotene) ( 28002826) Febrile seizures (MMR vaccine-related) ( 25344690) Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) ( 33208821) Waist circumference ( 31170924)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)
Interacting Genes		23 interacting genes: ATG5 ATXN3 BCL2 BID CAPNS1 CAPNS2 CASP9 CDK5R1 DUX4 F2RL1 GAS2 GRK2 KCTD7 KNG1 MAPK1 MTDH NFKBIA NMT1 PBXIP1 PTPN1 PTPRN TNS1 ZFYVE21	27 interacting genes: BRPF1 CAMLG CAPN2 CCDC85B DAXX DEF6 DPPA2 DSCR9 ESR1 GABARAPL1 GMCL1 GRB2 KRTAP10-6 LCA5L MDFI MDM2 MORF4L1 PCBD2 PPTC7 PRKAA2 SGTA TSNAX UBQLN1 UBQLN4 WASHC3 ZMYND8 ZZZ3
Entrez ID		824	57326
HPRD ID		00254	17823
Ensembl ID		ENSG00000162909	ENSG00000163346
Uniprot IDs		B4DN77 P17655 Q59EF6	B4E0K4 Q96AQ6
PDB IDs		1KFU 1KFX 2NQA
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Epithelial Cell Apoptotic Process Response To Nutrient Levels Positive Regulation Of Programmed Cell Death Cellular Response To Nutrient Levels Calpain Complex Lipopolysaccharide-mediated Signaling Pathway Regulation Of Signal Transduction B Cell Receptor Signaling Pathway Vasodilation Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium-dependent Cysteine-type Endopeptidase Activity Cellular Response To Starvation Regulation Of Autophagy Apoptotic Process Programmed Cell Death Cell Death Regulation Of Cell Population Proliferation Response To Starvation Pseudopodium Viral Genome Replication Regulation Of Biological Quality G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Peptidyl-threonine Phosphorylation Neuron Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Protease Binding Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Cellular Localization Cellular Response To Topologically Incorrect Protein Regulation Of Establishment Of Protein Localization Protein Phosphatase 2A Binding Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Iron Ion NF-kappaB Binding Regulation Of Transport Cellular Response To Stress Regulation Of Intracellular Signal Transduction Stem Cell Development	Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stress Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Metabolic Process Autophagy Regulation Of Primary Metabolic Process Regulation Of Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Metabolic Process Nucleus Chromatin Organization Cellular Response To Estrogen Stimulus Positive Regulation Of Proteolysis Regulation Of Macroautophagy Positive Regulation Of ERAD Pathway Autophagosome Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Protein Insertion Into ER Membrane
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