CAPN2 and KCTD7

Number of citations of the paper that reports this interaction (PubMedID 36964131)
96

Data Source:
BioGRID (enzymatic study)

		CAPN2	KCTD7
Description		calpain 2	potassium channel tetramerization domain containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Lysosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Dendrite Cortical Actin Cytoskeleton Pseudopodium Cell Projection Neuronal Cell Body Membrane Raft Extracellular Exosome Perinuclear Endoplasmic Reticulum Presynapse Postsynapse Calpain Complex	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Enzyme Binding Protein-containing Complex Binding Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Blastocyst Development Proteolysis Myoblast Fusion Female Pregnancy Response To Mechanical Stimulus Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Autoprocessing Protein Catabolic Process Regulation Of Interleukin-6 Production Cellular Response To Interferon-beta Response To Hydrogen Peroxide Behavioral Response To Pain Synaptic Vesicle Endocytosis Regulation Of Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Protein Catabolic Process At Postsynapse Positive Regulation Of Myoblast Fusion Positive Regulation Of Phosphatidylcholine Biosynthetic Process	Intracellular Potassium Ion Homeostasis Protein Homooligomerization Membrane Hyperpolarization Intracellular Glutamate Homeostasis
Pathways		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Carotenoid levels (alpha-carotene) ( 28002826) Febrile seizures (MMR vaccine-related) ( 25344690) Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) ( 33208821) Waist circumference ( 31170924)	Aortic root size ( 21223598) Cotinine glucuronidation ( 25293881) Estimated glomerular filtration rate ( 31152163)
Interacting Genes		23 interacting genes: ATG5 ATXN3 BCL2 BID CAPNS1 CAPNS2 CASP9 CDK5R1 DUX4 F2RL1 GAS2 GRK2 KCTD7 KNG1 MAPK1 MTDH NFKBIA NMT1 PBXIP1 PTPN1 PTPRN TNS1 ZFYVE21	44 interacting genes: ADAMTSL4 ATXN7L2 BAG4 CAPN1 CAPN2 CAPNS1 CUL3 DVL3 EFHC2 GAS2L2 GORASP2 INCA1 INO80B KAT5 KRT75 KRTAP13-3 LNX1 MDFI MEOX1 MEOX2 NIF3L1 NTAQ1 NXF1 PARVG PAX6 PIN1 PPARA PRPF18 PRR22 PSMA1 RAB4A REL TCEA2 TCEANC TERF1 TRIM2 TRIM3 UBC VEZF1 ZNF417 ZNF438 ZNF474 ZNF552 ZNF587
Entrez ID		824	154881
HPRD ID		00254	13770
Ensembl ID		ENSG00000162909	ENSG00000243335
Uniprot IDs		B4DN77 P17655 Q59EF6	Q96MP8
PDB IDs		1KFU 1KFX 2NQA
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Epithelial Cell Apoptotic Process Response To Nutrient Levels Positive Regulation Of Programmed Cell Death Cellular Response To Nutrient Levels Calpain Complex Lipopolysaccharide-mediated Signaling Pathway Regulation Of Signal Transduction B Cell Receptor Signaling Pathway Vasodilation Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium-dependent Cysteine-type Endopeptidase Activity Cellular Response To Starvation Regulation Of Autophagy Apoptotic Process Programmed Cell Death Cell Death Regulation Of Cell Population Proliferation Response To Starvation Pseudopodium Viral Genome Replication Regulation Of Biological Quality G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Peptidyl-threonine Phosphorylation Neuron Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Protease Binding Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Cellular Localization Cellular Response To Topologically Incorrect Protein Regulation Of Establishment Of Protein Localization Protein Phosphatase 2A Binding Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Iron Ion NF-kappaB Binding Regulation Of Transport Cellular Response To Stress Regulation Of Intracellular Signal Transduction Stem Cell Development	Calpain Complex Calcium-dependent Cysteine-type Endopeptidase Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Somite Specification Proteolysis Involved In Protein Catabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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