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NF1 and GRIN1
Number of citations of the paper that reports this interaction (PMID
10862698
)
203
Data Source:
HPRD
(in vivo)
NF1
GRIN1
Gene Name
neurofibromin 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Membrane
Axon
Dendrite
Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane
Endoplasmic Reticulum
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
N-methyl-D-aspartate Selective Glutamate Receptor Complex
Cell Junction
Dendrite
Dendrite Membrane
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Neuronal Postsynaptic Density
Molecular Function
Ras GTPase Activator Activity
Protein Binding
Phosphatidylethanolamine Binding
Phosphatidylcholine Binding
N-methyl-D-aspartate Selective Glutamate Receptor Activity
Extracellular-glutamate-gated Ion Channel Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Glycine Binding
Glutamate Binding
Enzyme Binding
Voltage-gated Cation Channel Activity
Glutamate Receptor Binding
Neurotransmitter Binding
Protein Heterodimerization Activity
Biological Process
MAPK Cascade
Osteoblast Differentiation
Metanephros Development
Response To Hypoxia
Liver Development
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Cell-matrix Adhesion
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Protein Kinase Activity
Cell Communication
Ras Protein Signal Transduction
Negative Regulation Of Neuroblast Proliferation
Brain Development
Peripheral Nervous System Development
Heart Development
Skeletal Muscle Tissue Development
Visual Learning
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Schwann Cell Development
Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Angiogenesis
Spinal Cord Development
Forebrain Astrocyte Development
Neural Tube Development
Cerebral Cortex Development
Myelination In Peripheral Nervous System
Actin Cytoskeleton Organization
Extracellular Matrix Organization
Collagen Fibril Organization
Adrenal Gland Development
Negative Regulation Of Cell Migration
Regulation Of Synaptic Transmission, GABAergic
Regulation Of Ras GTPase Activity
Positive Regulation Of Ras GTPase Activity
Negative Regulation Of Rac Protein Signal Transduction
Wound Healing
Negative Regulation Of Transcription Factor Import Into Nucleus
Positive Regulation Of Apoptotic Process
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of MAPK Cascade
Pigmentation
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Bone Resorption
Negative Regulation Of Osteoclast Differentiation
Regulation Of Glial Cell Differentiation
Positive Regulation Of Adenylate Cyclase Activity
Regulation Of Angiogenesis
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Neurotransmitter Secretion
Negative Regulation Of Fibroblast Proliferation
Regulation Of Long-term Neuronal Synaptic Plasticity
Sympathetic Nervous System Development
Camera-type Eye Morphogenesis
Negative Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Smooth Muscle Tissue Development
Artery Morphogenesis
Forebrain Morphogenesis
Cognition
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Conditioned Taste Aversion
Suckling Behavior
Response To Amphetamine
Cation Transport
Cellular Calcium Ion Homeostasis
Synaptic Transmission
Axon Guidance
Respiratory Gaseous Exchange
Long-term Memory
Adult Locomotory Behavior
Olfactory Learning
Visual Learning
Propylene Metabolic Process
Sensory Perception Of Pain
Pons Maturation
Cerebral Cortex Development
Ion Transmembrane Transport
Regulation Of Ion Transmembrane Transport
Social Behavior
Ionotropic Glutamate Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Regulation Of Membrane Potential
Positive Regulation Of Apoptotic Process
Response To Morphine
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Respiratory Gaseous Exchange
Response To Ethanol
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Ephrin Receptor Signaling Pathway
Regulation Of Long-term Neuronal Synaptic Plasticity
Rhythmic Process
Regulation Of Dendrite Morphogenesis
Regulation Of Axonogenesis
Protein Tetramerization
Response To Calcium Ion
Regulation Of Synapse Assembly
Calcium Ion Homeostasis
Regulation Of Excitatory Postsynaptic Membrane Potential
Prepulse Inhibition
Male Mating Behavior
Response To Fungicide
Calcium Ion Transmembrane Transport
Cellular Response To Manganese Ion
Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways
EPHB-mediated forward signaling
Axon guidance
Activation of NMDA receptor upon glutamate binding and postsynaptic events
CREB phosphorylation through the activation of CaMKII
EPH-Ephrin signaling
CREB phosphorylation through the activation of Ras
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Unblocking of NMDA receptor, glutamate binding and activation
Ras activation uopn Ca2+ infux through NMDA receptor
Post NMDA receptor activation events
Transmission across Chemical Synapses
Drugs
L-Glutamic Acid
Meperidine
Orphenadrine
Dcka, 5,7-Dichlorokynurenic Acid
D-Serine
Cycloleucine
Milnacipran
Agmatine
Diseases
GWAS
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Protein-Protein Interactions
13 interactors:
APP
DNAJC7
FAF2
GRIN1
GRIN2D
HRAS
MYOG
SDC2
SMAD2
SMAD3
SMAD4
TBPL1
VCP
53 interactors:
ACTN2
AKAP9
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
RAP2A
RPS6KA3
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
Entrez ID
4763
2902
HPRD ID
01203
15926
Ensembl ID
ENSG00000196712
ENSG00000176884
Uniprot IDs
P21359
Q05586
Q59GW0
Q5VSF9
PDB IDs
1NF1
2D4Q
2E2X
3P7Z
3PEG
3PG7
2HQW
2NR1
3BYA
Enriched GO Terms of Interacting Partners
?
SMAD Protein Complex Assembly
Response To Abiotic Stimulus
Cell Development
Regulation Of Cell Development
Regulation Of Cell Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Epithelial To Mesenchymal Transition
Response To Organic Substance
Axon Guidance
Cellular Component Assembly
Regulation Of Cellular Component Organization
Ionotropic Glutamate Receptor Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Stem Cell Differentiation
SMAD Protein Signal Transduction
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Cell Morphogenesis
Enzyme Linked Receptor Protein Signaling Pathway
Primary MiRNA Processing
Positive Regulation Of Macromolecule Biosynthetic Process
Visual Learning
Glutamate Receptor Signaling Pathway
DNA-templated Transcription, Initiation
Positive Regulation Of Gene Expression
Axonogenesis
Visual Behavior
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Binding
Cellular Response To Growth Factor Stimulus
Protein Complex Assembly
Axon Development
Endoderm Development
Anatomical Structure Morphogenesis
Cell Morphogenesis Involved In Neuron Differentiation
Embryonic Pattern Specification
Response To Growth Factor
Cell Differentiation
Regulation Of Transforming Growth Factor Beta2 Production
Paraxial Mesoderm Morphogenesis
Chemotaxis
Developmental Growth
Associative Learning
Positive Regulation Of Cellular Metabolic Process
Neuron Projection Morphogenesis
Response To External Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cell Proliferation
Ephrin Receptor Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Morphogenesis Involved In Differentiation
Synaptic Transmission
Cell-cell Signaling
Nervous System Development
Signaling
Locomotion
Cell Communication
Neurogenesis
Cell Differentiation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Organic Substance
Generation Of Neurons
Neuron Projection Development
Neuron Development
Developmental Process
Cell Development
Neuron Differentiation
Response To External Stimulus
Signal Transduction
Cell Projection Organization
Movement Of Cell Or Subcellular Component
Enzyme Linked Receptor Protein Signaling Pathway
Multicellular Organismal Development
System Development
Cellular Response To Stimulus
Anatomical Structure Development
Axon Development
Axon Guidance
Regulation Of Synaptic Transmission
Regulation Of Synaptic Plasticity
Neuron Projection Morphogenesis
Cell Surface Receptor Signaling Pathway
Axonogenesis
Cellular Response To Organic Substance
Response To Wounding
Cell Morphogenesis Involved In Neuron Differentiation
Cell Morphogenesis Involved In Differentiation
Learning
Response To Stimulus
Regulation Of Signaling
Chemotaxis
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Response To Abiotic Stimulus
Fibroblast Growth Factor Receptor Signaling Pathway
Blood Coagulation
Hemostasis
Cell Projection Morphogenesis
Single-organism Behavior
Cellular Response To Growth Factor Stimulus
Learning Or Memory
Tagcloud
?
american
artiodactyla
assigned
block
blot
cattle
chr
conservative
conserved
cow
electrophoresis
erbb2
hybrid
hybridization
localization
localized
means
mink
pepa
pig
prkca
rara
representatives
sheep
southern
swine
synteny
tk1
umph2
Tagcloud (Difference)
?
american
artiodactyla
assigned
block
blot
cattle
chr
conservative
conserved
cow
electrophoresis
erbb2
hybrid
hybridization
localization
localized
means
mink
pepa
pig
prkca
rara
representatives
sheep
southern
swine
synteny
tk1
umph2
Tagcloud (Intersection)
?