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NF1 and TBPL1
Number of citations of the paper that reports this interaction (PubMedID
15767669
)
43
Data Source:
HPRD
(in vivo)
NF1
TBPL1
Description
neurofibromin 1
TATA-box binding protein like 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Axon
Dendrite
Presynapse
Glutamatergic Synapse
Male Germ Cell Nucleus
Nucleus
Transcription Factor TFIIA Complex
Cytoplasm
Molecular Function
GTPase Activator Activity
Protein Binding
Lipid Binding
Phosphatidylethanolamine Binding
Phosphatidylcholine Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA Binding
Protein Binding
RNA Polymerase II General Transcription Initiation Factor Activity
General Transcription Initiation Factor Activity
Biological Process
MAPK Cascade
Angiogenesis
Osteoblast Differentiation
Metanephros Development
Response To Hypoxia
Liver Development
Endothelial Cell Proliferation
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Cell-matrix Adhesion
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Leukocyte Migration
Protein Import Into Nucleus
Apoptotic Process
Cell Communication
Ras Protein Signal Transduction
Neurotransmitter Secretion
Neuroblast Proliferation
Negative Regulation Of Neuroblast Proliferation
Brain Development
Peripheral Nervous System Development
Heart Development
Skeletal Muscle Tissue Development
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Visual Learning
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Gene Expression
Negative Regulation Of Schwann Cell Proliferation
Glial Cell Proliferation
Schwann Cell Proliferation
Schwann Cell Development
Cell Migration
Negative Regulation Of Angiogenesis
Rac Protein Signal Transduction
Spinal Cord Development
Amygdala Development
Forebrain Astrocyte Development
Neural Tube Development
Cerebral Cortex Development
Myelination In Peripheral Nervous System
Actin Cytoskeleton Organization
Extracellular Matrix Organization
Collagen Fibril Organization
Osteoclast Differentiation
Adrenal Gland Development
Negative Regulation Of Cell Migration
Regulation Of Synaptic Transmission, GABAergic
Mast Cell Apoptotic Process
Positive Regulation Of Mast Cell Apoptotic Process
Myeloid Cell Apoptotic Process
Positive Regulation Of Myeloid Cell Apoptotic Process
Cellular Response To Heat
Negative Regulation Of Rac Protein Signal Transduction
Schwann Cell Migration
Wound Healing
Regulation Of Cell Population Proliferation
Negative Regulation Of Protein Import Into Nucleus
Positive Regulation Of Apoptotic Process
Regulation Of MAPK Cascade
Negative Regulation Of MAPK Cascade
Pigmentation
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of GTPase Activity
Regulation Of Bone Resorption
Negative Regulation Of Osteoclast Differentiation
Regulation Of Glial Cell Differentiation
Regulation Of Angiogenesis
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Neurotransmitter Secretion
Fibroblast Proliferation
Negative Regulation Of Fibroblast Proliferation
Regulation Of Long-term Neuronal Synaptic Plasticity
Sympathetic Nervous System Development
Camera-type Eye Morphogenesis
Astrocyte Differentiation
Oligodendrocyte Differentiation
Negative Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Smooth Muscle Tissue Development
Hair Follicle Maturation
Artery Morphogenesis
Forebrain Morphogenesis
Regulation Of Developmental Process
Cognition
Neuron Apoptotic Process
Negative Regulation Of Glial Cell Proliferation
Long-term Synaptic Potentiation
Gamma-aminobutyric Acid Secretion, Neurotransmission
Glutamate Secretion, Neurotransmission
Regulation Of ERK1 And ERK2 Cascade
Mast Cell Proliferation
Negative Regulation Of Mast Cell Proliferation
Leukocyte Apoptotic Process
Stem Cell Proliferation
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Myeloid Leukocyte Migration
Observational Learning
Regulation Of Postsynapse Organization
Negative Regulation Of Schwann Cell Migration
Regulation Of Long-term Synaptic Potentiation
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Leukocyte Apoptotic Process
Negative Regulation Of Stem Cell Proliferation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Acrosome Assembly
DTTP Biosynthetic Process
DNA-templated Transcription Initiation
Transcription By RNA Polymerase II
Spermatogenesis
Spermatid Nucleus Differentiation
Nucleobase-containing Compound Biosynthetic Process
Pathways
Regulation of RAS by GAPs
RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Adventurousness (
30643258
)
Apolipoprotein B levels (
32203549
)
Appendicular lean mass (
33097823
)
Aspartate aminotransferase levels (
33547301
)
Bitter alcoholic beverage consumption (
31046077
)
Body size at age 10 (
32376654
)
Brain morphology (MOSTest) (
32665545
)
Endometrial cancer (
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Familial squamous cell lung carcinoma (
29924316
)
Feeling nervous (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Haemorrhoidal disease (
33888516
)
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
28552196
34021172
)
LDL cholesterol levels (
32203549
)
Low density lipoprotein cholesterol levels (
32154731
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Oily fish consumption (
32066663
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Pork consumption (
32066663
)
Total cholesterol levels (
29083408
)
Type 2 diabetes (
32499647
30297969
)
Height (
28552196
)
Night sleep phenotypes (
27126917
)
Interacting Genes
17 interacting genes:
AKT1
APP
CLK1
DNAJC7
EFS
EPHA2
GRIN1
GRIN2D
HRAS
HTR6
LIMK2
MAP2K3
RAF1
SDC2
SOX4
TBPL1
VCP
18 interacting genes:
ABCF3
APP
DVL3
FBXO7
GTF2A1
GTF2A2
GTF2B
IRAK4
LSM5
NDUFA6
NF1
PLIN3
PRNP
PTCD3
RAB35
RPL10
SLC35F6
TNNT1
Entrez ID
4763
9519
HPRD ID
01203
09272
Ensembl ID
ENSG00000196712
ENSG00000028839
Uniprot IDs
P21359
P62380
PDB IDs
1NF1
2D4Q
2E2X
3P7Z
3PEG
3PG7
6OB2
6OB3
6V65
6V6F
7MOC
7MP5
7MP6
7PGP
7PGQ
7PGR
7PGS
7PGT
7PGU
7R03
7R04
8E20
8EDL
8EDM
8EDN
8EDO
Enriched GO Terms of Interacting Partners
?
Intracellular Signaling Cassette
Positive Regulation Of Signal Transduction
Regulation Of Neuronal Synaptic Plasticity
Glial Cell Development
Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Ionotropic Glutamate Receptor Signaling Pathway
Positive Regulation Of Excitatory Postsynaptic Potential
Regulation Of Signal Transduction
Protein Kinase Activity
Regulation Of Intracellular Signal Transduction
Ligand-gated Ion Channel Signaling Pathway
Positive Regulation Of Phosphate Metabolic Process
Cellular Response To Oxygen-containing Compound
Modulation Of Excitatory Postsynaptic Potential
Regulation Of Protein Localization
Glutamate Receptor Signaling Pathway
NMDA Glutamate Receptor Activity
Glutamate Binding
Protein Serine Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Kinase Activity
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Excitatory Postsynaptic Potential
NMDA Selective Glutamate Receptor Complex
Glutamate-gated Calcium Ion Channel Activity
Regulation Of MAPK Cascade
Regulation Of Cell Projection Organization
Protein Serine/threonine Kinase Activity
Excitatory Chemical Synaptic Transmission
Regulation Of Synaptic Plasticity
Regulation Of Membrane Potential
Positive Regulation Of Protein Localization
Response To Radiation
Insulin Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Projection Assembly
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Postsynaptic Membrane Potential
Nucleotide Binding
Schwann Cell Development
Cell Development
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Cell Migration
Developmental Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Long-term Synaptic Potentiation
Cytosol
TBP-class Protein Binding
RNA Polymerase II General Transcription Initiation Factor Activity
Transcription Factor TFIIA Complex
Transcription Factor TFIID Complex
Protein Heterodimerization Activity
RNA Polymerase II Preinitiation Complex Assembly
RNA Polymerase II General Transcription Initiation Factor Binding
Transcription Initiation At RNA Polymerase II Promoter
Transcription Preinitiation Complex Assembly
Positive Regulation Of Neuron Apoptotic Process
Neuron Projection Maintenance
Regulation Of Dendritic Spine Maintenance
Negative Regulation Of Long-term Synaptic Potentiation
Transcription Preinitiation Complex
DNA-templated Transcription Initiation
Regulation Of Neuron Apoptotic Process
Intracellular Copper Ion Homeostasis
Copper Ion Homeostasis
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Cellular Response To Copper Ion
Molecular Function Activator Activity
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Postsynapse Organization
Response To Copper Ion
Amyloid-beta Complex
Growth Cone Lamellipodium
Neuron Projection Organization
Regulation Of Response To Calcium Ion
Response To Nerve Growth Factor
Amylin Binding
Positive Regulation Of Toll Signaling Pathway
Regulation Of Apoptotic Signaling Pathway
Frizzled Binding
Cellular Response To Nerve Growth Factor Stimulus
Protein-DNA Complex Assembly
Transcriptional Start Site Selection At RNA Polymerase II Promoter
Positive Regulation Of Mast Cell Apoptotic Process
Type 8 Metabotropic Glutamate Receptor Binding
Slow-twitch Skeletal Muscle Fiber Contraction
Glial Cytoplasmic Inclusion
Classical Lewy Body
Lewy Body Corona
Lewy Neurite
Negative Regulation Of Protein Localization To Nucleus
Regulation Of Synaptic Plasticity
Cellular Response To Amyloid-beta
Protein-containing Complex Assembly
Regulation Of Amyloid Precursor Protein Catabolic Process
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