NF1 and GRIN2D

Number of citations of the paper that reports this interaction (PMID 10862698)
203

Data Source:
HPRD (in vivo)

		NF1	GRIN2D
Gene Name		neurofibromin 1	glutamate receptor, ionotropic, N-methyl D-aspartate 2D
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Membrane Axon Dendrite Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane	Plasma Membrane N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Postsynaptic Membrane
	Molecular Function	Ras GTPase Activator Activity Protein Binding Phosphatidylethanolamine Binding Phosphatidylcholine Binding	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding
	Biological Process	MAPK Cascade Osteoblast Differentiation Metanephros Development Response To Hypoxia Liver Development Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Communication Ras Protein Signal Transduction Negative Regulation Of Neuroblast Proliferation Brain Development Peripheral Nervous System Development Heart Development Skeletal Muscle Tissue Development Visual Learning Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Schwann Cell Development Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Spinal Cord Development Forebrain Astrocyte Development Neural Tube Development Cerebral Cortex Development Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Extracellular Matrix Organization Collagen Fibril Organization Adrenal Gland Development Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Regulation Of Ras GTPase Activity Positive Regulation Of Ras GTPase Activity Negative Regulation Of Rac Protein Signal Transduction Wound Healing Negative Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Neuron Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Bone Resorption Negative Regulation Of Osteoclast Differentiation Regulation Of Glial Cell Differentiation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Angiogenesis Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotransmitter Secretion Negative Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Sympathetic Nervous System Development Camera-type Eye Morphogenesis Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Artery Morphogenesis Forebrain Morphogenesis Cognition Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Startle Response Signal Transduction Synaptic Transmission Adult Locomotory Behavior Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Sensory Perception Of Pain
Pathways			Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Meperidine Orphenadrine Tenocyclidine
Diseases
GWAS
Protein-Protein Interactions		13 interactors: APP DNAJC7 FAF2 GRIN1 GRIN2D HRAS MYOG SDC2 SMAD2 SMAD3 SMAD4 TBPL1 VCP	33 interactors: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA INADL MAP2 MAP2K2 NANOS1 NF1 PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3
Entrez ID		4763	2906
HPRD ID		01203	04095
Ensembl ID		ENSG00000196712	ENSG00000105464
Uniprot IDs		P21359	O15399 Q59G17
PDB IDs		1NF1 2D4Q 2E2X 3P7Z 3PEG 3PG7
Enriched GO Terms of Interacting Partners?		SMAD Protein Complex Assembly Response To Abiotic Stimulus Cell Development Regulation Of Cell Development Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial To Mesenchymal Transition Response To Organic Substance Axon Guidance Cellular Component Assembly Regulation Of Cellular Component Organization Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Stem Cell Differentiation SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cell Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Primary MiRNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Visual Learning Glutamate Receptor Signaling Pathway DNA-templated Transcription, Initiation Positive Regulation Of Gene Expression Axonogenesis Visual Behavior Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Cellular Response To Growth Factor Stimulus Protein Complex Assembly Axon Development Endoderm Development Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Embryonic Pattern Specification Response To Growth Factor Cell Differentiation Regulation Of Transforming Growth Factor Beta2 Production Paraxial Mesoderm Morphogenesis Chemotaxis Developmental Growth Associative Learning Positive Regulation Of Cellular Metabolic Process Neuron Projection Morphogenesis Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Ephrin Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation	Nervous System Development Regulation Of MAPK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurogenesis Cell Development Locomotion Generation Of Neurons Intracellular Signal Transduction Neuron Projection Development Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Neuronal Synaptic Plasticity Cellular Response To Stimulus Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Cell Projection Organization Signaling Cell Morphogenesis Involved In Differentiation Axonogenesis MyD88-independent Toll-like Receptor Signaling Pathway Neuron Development Cell Communication Apoptotic Process Response To Organic Substance Signal Transduction Axon Guidance Axon Development Programmed Cell Death Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Death Toll-like Receptor 4 Signaling Pathway Death Regulation Of Neuron Death Developmental Process Neuron Projection Morphogenesis Response To Ammonium Ion Immune Response-regulating Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Response To Morphine Regulation Of Intracellular Signal Transduction Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development Response To External Stimulus Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink pepa pig prkca rara representatives sheep southern swine synteny tk1 umph2	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink pepa pig prkca rara representatives sheep southern swine synteny tk1 umph2	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?