NDUFA6 and HSPB2

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		NDUFA6	HSPB2
Description		NADH:ubiquinone oxidoreductase subunit A6	heat shock protein family B (small) member 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex I	Nucleus Cytoplasm Cytosol
	Molecular Function	NADH Dehydrogenase (ubiquinone) Activity	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Mitochondrial Respiratory Chain Complex I Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process
Pathways		Respiratory electron transport Complex I biogenesis
Drugs		NADH
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Intelligence ( 28530673) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: ATP5MF BAG6 HSPB2 TBPL1	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		4700	3316
HPRD ID		11884	03712
Ensembl ID		ENSG00000184983	ENSG00000170276
Uniprot IDs		A0A2Y9D025 P56556	A8KAH6 Q16082
PDB IDs		5XTB 5XTD 5XTH 5XTI	6F2R
Enriched GO Terms of Interacting Partners?		Somatic Muscle Development Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Maintenance Of Unfolded Protein BAT3 Complex Nucleoside Triphosphate Biosynthetic Process General Transcription Initiation Factor Activity Nucleotide Biosynthetic Process DTTP Biosynthetic Process Transcription Factor TFIIA Complex Nucleoside Phosphate Biosynthetic Process Pyrimidine Deoxyribonucleotide Biosynthetic Process Internal Protein Amino Acid Acetylation Internal Peptidyl-lysine Acetylation Protein Carrier Chaperone NK T Cell Activation Spermatid Nucleus Differentiation Structural Constituent Of Eye Lens Male Gamete Generation Peptidyl-lysine Acetylation Synaptonemal Complex Assembly Spermatogenesis Proteasome Binding Positive Regulation Of ERAD Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ubiquitin-specific Protease Binding Misfolded Protein Binding Tail-anchored Membrane Protein Insertion Into ER Membrane Deoxyribonucleotide Biosynthetic Process Nucleotide Metabolic Process 2'-deoxyribonucleotide Biosynthetic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Carbohydrate Derivative Biosynthetic Process Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATP Synthase Complex Gamete Generation Synaptonemal Complex Organization Organophosphate Biosynthetic Process Regulation Of ERAD Pathway Nucleoside Phosphate Metabolic Process Protein Refolding Nucleobase-containing Small Molecule Metabolic Process Protein Targeting To ER Protein Insertion Into ER Membrane Acrosome Assembly Pyrimidine Nucleotide Biosynthetic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Acetylation Establishment Of Protein Localization To Endoplasmic Reticulum Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding	Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding
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