NARS1 and HSPB2

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		NARS1	HSPB2
Description		asparaginyl-tRNA synthetase 1	heat shock protein family B (small) member 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Aminoacyl-tRNA Ligase Activity Asparagine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity CCR3 Chemokine Receptor Binding Protein Dimerization Activity	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Asparaginyl-tRNA Aminoacylation Cell Migration Cerebral Cortex Development	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process
Pathways		Cytosolic tRNA aminoacylation
Drugs		Asparagine
Diseases
GWAS			Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: ATXN1 CEBPA DSCR9 HSPB2 LSM1 SUMO2	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		4677	3316
HPRD ID		00154	03712
Ensembl ID		ENSG00000134440	ENSG00000170276
Uniprot IDs		O43776	A8KAH6 Q16082
PDB IDs		4ZYA 5XIX 8H53 8TC7 8TC8 8TC9	6F2R
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Nuclear Matrix Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 White Fat Cell Proliferation Memory C/EBP Complex Regulation Of Cell Differentiation Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Somatic Muscle Development POZ Domain Binding Lsm1-7-Pat1 Complex Positive Regulation Of Proteolysis Response To Phenylpropanoid Regulation Of Proteasomal Protein Catabolic Process Anterior/posterior Axon Guidance Negative Regulation Of Dendrite Development Positive Regulation Of Protein Catabolic Process Fat Cell Proliferation Poly(G) Binding Regulation Of Cell Development Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Postsynapse	Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding
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