RFC1 and TCEAL1

Number of citations of the paper that reports this interaction (PMID 10353443)
2

Data Source:
HPRD (in vivo)

		RFC1	TCEAL1
Gene Name		replication factor C (activator 1) 1, 145kDa	transcription elongation factor A (SII)-like 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Nucleolus Golgi Apparatus Cell Junction Extracellular Vesicular Exosome	Nucleus Nucleoplasm
	Molecular Function	DNA Binding DNA Clamp Loader Activity Double-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity Protein Domain Specific Binding Sequence-specific DNA Binding	Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Transcription, DNA-templated Telomere Maintenance Via Telomerase Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Catalytic Activity Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated
Pathways		Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: BRCA1 BRD4 CASP3 CCND1 CDK4 CEBPA CSNK2B HDAC1 MYOC PCNA RELA RFC2 RFC3 RFC4 SMC1A SSBP3 TCEAL1 YWHAQ ZSCAN1	2 interactors: HOXB6 RFC1
Entrez ID		5981	9338
HPRD ID		00024	02211
Ensembl ID		ENSG00000035928	ENSG00000172465
Uniprot IDs		P35251	Q15170
PDB IDs		2EBU 2K6G 2K7F
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling Cell Cycle Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Response To DNA Damage Stimulus Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Chromosome Organization Transcription-coupled Nucleotide-excision Repair Nucleobase-containing Compound Metabolic Process Cell Cycle Process Negative Regulation Of Cell Cycle Cellular Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance Nitrogen Compound Metabolic Process Cellular Response To Stimulus Organelle Organization Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Nucleotide-excision Repair DNA Recombination Anatomical Structure Development Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA-dependent DNA Replication DNA Replication Regulation Of Metabolic Process Developmental Process Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process DNA Repair Multicellular Organismal Development Response To Organic Substance Regulation Of G2/M Transition Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Biosynthetic Process DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus	Methotrexate Transport Folic Acid Transport Telomere Maintenance Via Telomerase Folic Acid Metabolic Process Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication RNA-dependent DNA Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Cofactor Transport Transcription-coupled Nucleotide-excision Repair Homeostatic Process Drug Transport Vitamin Transport Folic Acid-containing Compound Metabolic Process Pteridine-containing Compound Metabolic Process Telomere Maintenance Dicarboxylic Acid Transport Water-soluble Vitamin Metabolic Process Nucleotide-excision Repair Dicarboxylic Acid Metabolic Process DNA-dependent DNA Replication Vitamin Metabolic Process Transcription, DNA-templated Erythrocyte Homeostasis RNA Biosynthetic Process Embryonic Skeletal System Morphogenesis Amide Transport Myeloid Cell Homeostasis
Tagcloud ?		b12 bnip3 brac1 brca1 c1420t c1561t cnnd1 cpg cshmt dependency g80a gcpii homocysteine hyperhomocysteinemia hypermethylation hypomethioninemia hypothesize influencing inverse inversely island loci methionine methylation positively rarbeta1 rassf1 remethylation suppressors
Tagcloud (Difference) ?		b12 bnip3 brac1 brca1 c1420t c1561t cnnd1 cpg cshmt dependency g80a gcpii homocysteine hyperhomocysteinemia hypermethylation hypomethioninemia hypothesize influencing inverse inversely island loci methionine methylation positively rarbeta1 rassf1 remethylation suppressors
Tagcloud (Intersection) ?