RFC1 and SSBP3

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		RFC1	SSBP3
Gene Name		replication factor C (activator 1) 1, 145kDa	single stranded DNA binding protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Nucleolus Golgi Apparatus Cell Junction Extracellular Vesicular Exosome	Nucleus Protein Complex
	Molecular Function	DNA Binding DNA Clamp Loader Activity Double-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity Protein Domain Specific Binding Sequence-specific DNA Binding	Single-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Transcription, DNA-templated Telomere Maintenance Via Telomerase Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Catalytic Activity Positive Regulation Of Transcription, DNA-templated	Hematopoietic Progenitor Cell Differentiation Transcription, DNA-templated Protein Complex Assembly Positive Regulation Of Cell Proliferation Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Head Morphogenesis Positive Regulation Of Anterior Head Development
Pathways		Polymerase switching on the C-strand of the telomere Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Gap-filling DNA repair synthesis and ligation in TC-NER Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres S Phase Telomere C-strand (Lagging Strand) Synthesis Leading Strand Synthesis DNA strand elongation Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Polymerase switching Global Genomic NER (GG-NER) Telomere Maintenance Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: BRCA1 BRD4 CASP3 CCND1 CDK4 CEBPA CSNK2B HDAC1 MYOC PCNA RELA RFC2 RFC3 RFC4 SMC1A SSBP3 TCEAL1 YWHAQ ZSCAN1	16 interactors: ANKEF1 APP ARNT2 EWSR1 HCLS1 IL36RN LDB1 LDB2 LMX1B NXT2 PIN1 RFC1 SUPT5H TBC1D23 YES1 ZNF226
Entrez ID		5981	23648
HPRD ID		00024	09578
Ensembl ID		ENSG00000035928	ENSG00000157216
Uniprot IDs		P35251	Q9BWW4
PDB IDs		2EBU 2K6G 2K7F
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling Cell Cycle Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Response To DNA Damage Stimulus Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Chromosome Organization Transcription-coupled Nucleotide-excision Repair Nucleobase-containing Compound Metabolic Process Cell Cycle Process Negative Regulation Of Cell Cycle Cellular Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance Nitrogen Compound Metabolic Process Cellular Response To Stimulus Organelle Organization Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Nucleotide-excision Repair DNA Recombination Anatomical Structure Development Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA-dependent DNA Replication DNA Replication Regulation Of Metabolic Process Developmental Process Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process DNA Repair Multicellular Organismal Development Response To Organic Substance Regulation Of G2/M Transition Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Biosynthetic Process DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Epithelial Structure Maintenance Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Cerebellum Morphogenesis Gene Expression Regulation Of Cellular Process Regulation Of DNA-templated Transcription, Elongation Hindbrain Morphogenesis Histone H3-K4 Acetylation Negative Regulation Of Interferon-gamma Secretion Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Somatic Stem Cell Maintenance Brain Development Negative Regulation Of Cellular Metabolic Process Homeostatic Process Head Development Innate Immune Response Antifungal Humoral Response Synaptic Growth At Neuromuscular Junction Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Trabecular Meshwork Development Positive Regulation Of Hemoglobin Biosynthetic Process Hair Follicle Development Hair Cycle Process Collateral Sprouting In Absence Of Injury Regulation Of Interleukin-6 Production Hair Cycle Cerebellum Development Regulation Of Receptor Activity Central Nervous System Development Metencephalon Development Response To Organic Substance Collateral Sprouting Axon Midline Choice Point Recognition
Tagcloud ?		b12 bnip3 brac1 brca1 c1420t c1561t cnnd1 cpg cshmt dependency g80a gcpii homocysteine hyperhomocysteinemia hypermethylation hypomethioninemia hypothesize influencing inverse inversely island loci methionine methylation positively rarbeta1 rassf1 remethylation suppressors	applicable biogenesis btb btbd9 clones crlf3 detail easily elusive head legs microvesicles morphogenesis morphology nervous pc12 phenotypes pheochromocytoma poz restless slmvs stranded synaptic theoretically transport trapped uncovering vesicle vesicles
Tagcloud (Difference) ?		b12 bnip3 brac1 brca1 c1420t c1561t cnnd1 cpg cshmt dependency g80a gcpii homocysteine hyperhomocysteinemia hypermethylation hypomethioninemia hypothesize influencing inverse inversely island loci methionine methylation positively rarbeta1 rassf1 remethylation suppressors	applicable biogenesis btb btbd9 clones crlf3 detail easily elusive head legs microvesicles morphogenesis morphology nervous pc12 phenotypes pheochromocytoma poz restless slmvs stranded synaptic theoretically transport trapped uncovering vesicle vesicles
Tagcloud (Intersection) ?