RFC1 and RFC3

Number of citations of the paper that reports this interaction (PubMedID 8692848)
31

Data Source:
HPRD (in vitro, in vivo)

		RFC1	RFC3
Description		replication factor C subunit 1	replication factor C subunit 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Elg1 RFC-like Complex Protein-containing Complex Extracellular Exosome	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Ctf18 RFC-like Complex Protein-containing Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Double-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATP Hydrolysis Activity Protein Domain Specific Binding Sequence-specific DNA Binding DNA Clamp Unloader Activity DNA-binding Transcription Factor Binding	DNA Binding DNA Clamp Loader Activity Protein Binding ATP-dependent Activity, Acting On DNA Single-stranded DNA Helicase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA-templated DNA Replication DNA Repair Telomere Maintenance Via Telomerase Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 30929738) Asthma (adult onset) ( 30929738) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494)	Alzheimer's disease ( 20061627) Colorectal cancer or advanced adenoma ( 30510241) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Obesity-related traits ( 23251661)
Interacting Genes		20 interacting genes: BRCA1 BRD4 CASP3 CCND1 CDK4 CEBPA CSNK2B HDAC1 MYOC PCNA RELA RFC2 RFC3 SMC1A SSBP3 TCEAL1 UBC USP7 YWHAQ ZSCAN1	14 interacting genes: ANKRD40 ARFGAP1 CEBPA CHTF8 INCA1 KHDRBS2 KHDRBS3 MESD PCNA PICK1 PTEN RAD17 RFC1 RFC4
Entrez ID		5981	5983
HPRD ID		00024	02676
Ensembl ID		ENSG00000035928	ENSG00000133119
Uniprot IDs		P35251	P40938
PDB IDs		2EBU 2K6G 2K7F 6VVO	6VVO 7Z6H 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ
Enriched GO Terms of Interacting Partners?		DNA Damage Response Positive Regulation Of DNA-directed DNA Polymerase Activity Enzyme Binding Nucleoplasm Nucleus Cellular Response To Stress Response To Xenobiotic Stimulus Chromatin Binding Cyclin D1-CDK4 Complex P53 Binding Protein-containing Complex Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Response To Ketone Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Liver Development Response To Steroid Hormone Symbiont-mediated Disruption Of Host Cell PML Body Transcription Regulator Complex Response To Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Transcription Cis-regulatory Region Binding Response To Tumor Necrosis Factor DNA Replication Factor C Complex Histone Deacetylase Binding Regulation Of Metabolic Process Response To Glucocorticoid Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Positive Regulation Of DNA Biosynthetic Process DNA Repair Condensed Nuclear Chromosome Ctf18 RFC-like Complex Response To Corticosteroid Response To UV Animal Organ Regeneration DNA Clamp Loader Activity Protein-containing Complex Binding Negative Regulation Of Macromolecule Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Vitamin Negative Regulation Of Macromolecule Biosynthetic Process Host-mediated Suppression Of Viral Transcription Chromosome	DNA Clamp Loader Activity Positive Regulation Of DNA-directed DNA Polymerase Activity Elg1 RFC-like Complex Positive Regulation Of DNA Biosynthetic Process DNA Replication DNA Replication Factor C Complex Ctf18 RFC-like Complex Protein Domain Specific Binding Regulation Of DNA Biosynthetic Process Nucleic Acid Metabolic Process DNA Strand Elongation Involved In DNA Replication Single-stranded DNA Helicase Activity DNA Strand Elongation Negative Regulation Of Cell Cycle Nucleoplasm Identical Protein Binding DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Dendritic Spine Organization Response To Dexamethasone Regulation Of DNA Metabolic Process Neuron Projection Organization Postsynapse Organization DNA Repair Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding PCNA Complex Replisome Negative Regulation Of Synaptic Vesicle Clustering Rad17 RFC-like Complex DNA-templated DNA Replication Regulation Of Catalytic Activity Cellular Response To Stress Animal Organ Regeneration Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Vitamin B2 C/EBP Complex PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Positive Regulation Of DNA Metabolic Process Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity DNA Clamp Unloader Activity Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Catalytic Activity
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