RFC1 and RFC2

Number of citations of the paper that reports this interaction (PubMedID 37071682)
87

Data Source:
BioGRID (cross-linking study)
HPRD (in vivo)

		RFC1	RFC2
Description		replication factor C subunit 1	replication factor C subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Elg1 RFC-like Complex Protein-containing Complex Extracellular Exosome	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Ctf18 RFC-like Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Double-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATP Hydrolysis Activity Protein Domain Specific Binding Sequence-specific DNA Binding DNA Clamp Unloader Activity DNA-binding Transcription Factor Binding	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA-templated DNA Replication DNA Repair Telomere Maintenance Via Telomerase Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription	DNA Replication DNA-templated DNA Replication DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 30929738) Asthma (adult onset) ( 30929738) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494)
Interacting Genes		20 interacting genes: BRCA1 BRD4 CASP3 CCND1 CDK4 CEBPA CSNK2B HDAC1 MYOC PCNA RELA RFC2 RFC3 SMC1A SSBP3 TCEAL1 UBC USP7 YWHAQ ZSCAN1	14 interacting genes: CEBPA HGS KLHL20 PCNA PRKAR1A PSMA1 RAD17 RAD18 RFC1 RFC4 RFC5 SUMO2 YOD1 ZIC1
Entrez ID		5981	5982
HPRD ID		00024	02675
Ensembl ID		ENSG00000035928	ENSG00000049541
Uniprot IDs		P35251	A0A087WVY3 P35250 Q75MT5
PDB IDs		2EBU 2K6G 2K7F 6VVO	6VVO 7Z6H 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ
Enriched GO Terms of Interacting Partners?		DNA Damage Response Positive Regulation Of DNA-directed DNA Polymerase Activity Enzyme Binding Nucleoplasm Nucleus Cellular Response To Stress Response To Xenobiotic Stimulus Chromatin Binding Cyclin D1-CDK4 Complex P53 Binding Protein-containing Complex Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Response To Ketone Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Liver Development Response To Steroid Hormone Symbiont-mediated Disruption Of Host Cell PML Body Transcription Regulator Complex Response To Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Transcription Cis-regulatory Region Binding Response To Tumor Necrosis Factor DNA Replication Factor C Complex Histone Deacetylase Binding Regulation Of Metabolic Process Response To Glucocorticoid Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Positive Regulation Of DNA Biosynthetic Process DNA Repair Condensed Nuclear Chromosome Ctf18 RFC-like Complex Response To Corticosteroid Response To UV Animal Organ Regeneration DNA Clamp Loader Activity Protein-containing Complex Binding Negative Regulation Of Macromolecule Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Vitamin Negative Regulation Of Macromolecule Biosynthetic Process Host-mediated Suppression Of Viral Transcription Chromosome	DNA Clamp Loader Activity DNA Replication Factor C Complex Positive Regulation Of DNA-directed DNA Polymerase Activity Elg1 RFC-like Complex DNA Repair Macromolecule Metabolic Process DNA Replication Positive Regulation Of DNA Biosynthetic Process DNA-templated DNA Replication Ctf18 RFC-like Complex Cellular Response To Stress DNA Metabolic Process DNA Damage Response Protein Domain Specific Binding Regulation Of DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Ubiquitin Protein Ligase Binding Single-stranded DNA Helicase Activity DNA Strand Elongation Chromosome Ubiquitin-like Protein Ligase Binding Replication Fork Nucleoplasm Regulation Of Primary Metabolic Process Postreplication Repair Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process PCNA Complex Replisome Rad17 RFC-like Complex Type II Interferon Binding Rad6-Rad18 Complex Animal Organ Regeneration DNA Binding Regulation Of Catalytic Activity Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Vitamin B2 C/EBP Complex Damaged DNA Binding PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Positive Regulation Of DNA Metabolic Process Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
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