RFC1

Description		replication factor C subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Elg1 RFC-like Complex Protein-containing Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Double-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATP Hydrolysis Activity Protein Domain Specific Binding Sequence-specific DNA Binding DNA Clamp Unloader Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA-templated DNA Replication DNA Repair Telomere Maintenance Via Telomerase Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 30929738) Asthma (adult onset) ( 30929738) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494)
Novel Interacting Genes		1 novel interacting genes: PCDH7
Interacting Genes		20 interacting genes: BRCA1 BRD4 CASP3 CCND1 CDK4 CEBPA CSNK2B HDAC1 MYOC PCNA RELA RFC2 RFC3 SMC1A SSBP3 TCEAL1 UBC USP7 YWHAQ ZSCAN1
Entrez ID		5981
HPRD ID		00024
Ensembl ID		ENSG00000035928
Uniprot IDs		P35251
PDB IDs		2EBU 2K6G 2K7F 6VVO
Enriched GO Terms of Interacting Partners?		DNA Damage Response Positive Regulation Of DNA-directed DNA Polymerase Activity Enzyme Binding Nucleoplasm Nucleus Cellular Response To Stress Response To Xenobiotic Stimulus Chromatin Binding Cyclin D1-CDK4 Complex P53 Binding Protein-containing Complex Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Response To Ketone Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Liver Development Response To Steroid Hormone Symbiont-mediated Disruption Of Host Cell PML Body Transcription Regulator Complex Response To Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Transcription Cis-regulatory Region Binding Response To Tumor Necrosis Factor DNA Replication Factor C Complex Histone Deacetylase Binding Regulation Of Metabolic Process Response To Glucocorticoid Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Positive Regulation Of DNA Biosynthetic Process DNA Repair Condensed Nuclear Chromosome Ctf18 RFC-like Complex Response To Corticosteroid Response To UV Animal Organ Regeneration DNA Clamp Loader Activity Protein-containing Complex Binding Negative Regulation Of Macromolecule Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Vitamin Negative Regulation Of Macromolecule Biosynthetic Process Host-mediated Suppression Of Viral Transcription Chromosome
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