BMF and NNMT

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BMF	NNMT
Description		Bcl2 modifying factor	nicotinamide N-methyltransferase
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane Cytosol Plasma Membrane Myosin Complex	Cytoplasm Cytosol
	Molecular Function	Protein Binding	Nicotinamide N-methyltransferase Activity Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Pyridine N-methyltransferase Activity
	Biological Process	Apoptotic Process Negative Regulation Of Autophagy Positive Regulation Of Protein-containing Complex Assembly Cellular Response To UV Positive Regulation Of Apoptotic Process Anoikis Positive Regulation Of Release Of Cytochrome C From Mitochondria	Nicotinamide Metabolic Process Methylation NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Deacetylation
Pathways		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of BMF and translocation to mitochondria	Methylation Nicotinate metabolism Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs			Niacin
Diseases
GWAS		B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 24292274 26956414 28165464) Dehydroepiandrosterone sulphate levels ( 21533175) Endometrial cancer ( 27135401 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Ewing sarcoma ( 22327514) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Triglyceride levels ( 32203549)	Asthma ( 29273806) Diisocyanate-induced asthma ( 25918132) Volumetric brain MRI ( 17903297)
Interacting Genes		26 interacting genes: AQP1 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BCL2L2-PABPN1 CTAG1A CTAG1B CXCL9 DYNLL1 DYNLL2 GPSM3 LCN2 MAPK8 MCL1 MGAT5B MYO5A NNMT RECK REL SEC14L4 SHC3 TCF12 TFIP11 TRIM54	3 interacting genes: APP ATF6 BMF
Entrez ID		90427	4837
HPRD ID		05881	02478
Ensembl ID		ENSG00000104081	ENSG00000166741
Uniprot IDs		Q96LC9	B0YJ53 P40261
PDB IDs		7CNU 8IQK 8IQL 8IQM 8R58	2IIP 3ROD 5YJF 6CHH 6ORR 6PVE 6PVS 7BKG 7BLE 7EGU 7EHZ 7EI2 7ET7 7EU5 7NBJ 7NBM 7NBQ 7RKK 7RKL 7SOK 7WMC 7WMT 9ATV
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage BH3 Domain Binding Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Mitochondrial Outer Membrane Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Damage Response Mitochondrion Organization Negative Regulation Of Apoptotic Process Negative Regulation Of Anoikis Negative Regulation Of Programmed Cell Death Dendritic Cell Apoptotic Process Cellular Response To Stress Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Microtubule Associated Complex Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Stress Programmed Cell Death Cell Death Cell Surface Receptor Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Response To Reactive Oxygen Species Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Mitochondrial Fusion TRNA Threonylcarbamoyladenosine Metabolic Process Response To Radiation Response To Hydrogen Peroxide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To External Biotic Stimulus Programmed Cell Death Involved In Cell Development Regulation Of Neuron Apoptotic Process Negative Regulation Of Autophagy Cytoplasmic Dynein Complex Cellular Response To Reactive Oxygen Species Nuclear Membrane Identical Protein Binding Cytoplasm Metanephric Descending Thin Limb Development Cellular Response To Decreased Oxygen Levels	Enzyme Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Protein Heterodimerization Activity Positive Regulation Of Response To Endoplasmic Reticulum Stress Protein-folding Chaperone Binding Survivin Complex Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ATF6-mediated Unfolded Protein Response Peptidase Inhibitor Activity Positive Regulation Of Mitotic Cell Cycle Cell Death Apoptotic Process Nervous System Process Programmed Cell Death Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Exit From Mitosis Cobalt Ion Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Intracellular Signal Transduction Interphase Microtubule Organizing Center Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Chromosome Passenger Complex
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