BMF and SEC14L4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		BMF	SEC14L4
Description		Bcl2 modifying factor	SEC14 like lipid binding 4
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane Cytosol Plasma Membrane Myosin Complex	Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Lipid Binding
	Biological Process	Apoptotic Process Negative Regulation Of Autophagy Positive Regulation Of Protein-containing Complex Assembly Cellular Response To UV Positive Regulation Of Apoptotic Process Anoikis Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of BMF and translocation to mitochondria
Drugs			Vitamin E
Diseases
GWAS		B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 24292274 26956414 28165464) Dehydroepiandrosterone sulphate levels ( 21533175) Endometrial cancer ( 27135401 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Ewing sarcoma ( 22327514) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Triglyceride levels ( 32203549)	Brain morphology (MOSTest) ( 32665545) hemolysis of donated blood (oxidative) ( 34014839) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		26 interacting genes: AQP1 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BCL2L2-PABPN1 CTAG1A CTAG1B CXCL9 DYNLL1 DYNLL2 GPSM3 LCN2 MAPK8 MCL1 MGAT5B MYO5A NNMT RECK REL SEC14L4 SHC3 TCF12 TFIP11 TRIM54	21 interacting genes: BMF CRX CTAG1A CTAG1B HAO2 INCA1 KRT31 KRT34 MEOX1 MEOX2 PAX5 PAX6 PLEKHF2 REL RHOU SERTAD1 TCF4 TEPSIN TRIM54 USHBP1 ZMYND12
Entrez ID		90427	284904
HPRD ID		05881	15312
Ensembl ID		ENSG00000104081	ENSG00000133488
Uniprot IDs		Q96LC9	B2RMR2 B3KRP9 Q9UDX3
PDB IDs		7CNU 8IQK 8IQL 8IQM 8R58	4TLG
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage BH3 Domain Binding Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Mitochondrial Outer Membrane Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Damage Response Mitochondrion Organization Negative Regulation Of Apoptotic Process Negative Regulation Of Anoikis Negative Regulation Of Programmed Cell Death Dendritic Cell Apoptotic Process Cellular Response To Stress Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Microtubule Associated Complex Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Stress Programmed Cell Death Cell Death Cell Surface Receptor Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Response To Reactive Oxygen Species Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Mitochondrial Fusion TRNA Threonylcarbamoyladenosine Metabolic Process Response To Radiation Response To Hydrogen Peroxide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To External Biotic Stimulus Programmed Cell Death Involved In Cell Development Regulation Of Neuron Apoptotic Process Negative Regulation Of Autophagy Cytoplasmic Dynein Complex Cellular Response To Reactive Oxygen Species Nuclear Membrane Identical Protein Binding Cytoplasm Metanephric Descending Thin Limb Development Cellular Response To Decreased Oxygen Levels	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Somite Specification Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding HMG Box Domain Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Segment Specification Somite Development TRNA Threonylcarbamoyladenosine Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of RNA Metabolic Process Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Coated Vesicle Membrane
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