BMF and BCL2L1

Number of citations of the paper that reports this interaction (PMID 15694340)
428

Data Source:
BioGRID (unspecified method, two hybrid, affinity chromatography technology)
HPRD (in vitro)

		BMF	BCL2L1
Gene Name		Bcl2 modifying factor	BCL2-like 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Mitochondrial Outer Membrane Cytosol Plasma Membrane Myosin Complex	Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Centrosome Cytosol Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Nuclear Membrane Bcl-2 Family Protein Complex
	Molecular Function	Protein Binding	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding
	Biological Process	Apoptotic Process Positive Regulation Of Protein Homooligomerization Anoikis Positive Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cytokinesis Ovarian Follicle Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Endocytosis Apoptotic Process Mitotic Cell Cycle Checkpoint Germ Cell Development Spermatogenesis Cell Proliferation Positive Regulation Of Cell Proliferation Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Fertilization Negative Regulation Of Autophagy Suppression By Virus Of Host Apoptotic Process Response To Cytokine Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Cycloheximide Regulation Of Mitochondrial Membrane Permeability Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Cellular Process Regulating Host Cell Cycle In Response To Virus Mitochondrion Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Alkaloid Cellular Response To Gamma Radiation Apoptotic Process In Bone Marrow Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Programmed Cell Death Activation of BH3-only proteins BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of BMF and translocation to mitochondria Intrinsic Pathway for Apoptosis	Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Programmed Cell Death BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Innate Immune System Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Dehydroepiandrosterone sulphate levels ( 21533175) Ewing sarcoma ( 22327514)
Protein-Protein Interactions		15 interactors: BCL2 BCL2A1 BCL2L1 BCL2L2 CXCL9 DYNLL1 DYNLL2 MAPK8 MCL1 MYO5A NNMT REL SEC14L4 TCF12 TFIP11	79 interactors: ACTB AKT1 ANTXR1 APAF1 AVEN BAD BAG1 BAK1 BAX BBC3 BCAP31 BCL2 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BID BIK BLK BMF BNIP1 BNIP3 BNIP3L BNIPL CAPN1 CASP1 CASP8 CASP9 CDKN2A CFLAR CRYAA CRYAB CYCS DOCK7 EDRF1 FBP1 FKBP8 GLOD4 HRK IKZF3 IRS1 IRS2 LARP1 MAPK8 MCL1 METTL23 MOAP1 MTOR NLRP1 PARK7 PDIA4 PLD3 PMAIP1 PPHLN1 PPP1CA PSEN1 PSEN2 PTN RAD9A RAF1 RBM5 RTN1 RTN4 SIVA1 SNCA SPNS1 TLE1 TMBIM6 TP53 TP53BP2 TPT1 UBR1 UHRF2 VDAC1 ZFYVE1 ZHX1 ZNF219
Entrez ID		90427	598
HPRD ID		05881	02497
Ensembl ID		ENSG00000104081	ENSG00000171552
Uniprot IDs		Q96LC9	Q07817 Q5TE63
PDB IDs			1BXL 1G5J 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 2B48 2LP8 2LPC 2M03 2M04 2O1Y 2O2M 2O2N 2P1L 2PON 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 3ZK6 3ZLN 3ZLO 3ZLR 4A1U 4A1W 4AQ3 4EHR 4HNJ 4IEH
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Mitochondrion Organization Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Regulation Of Cell Death Negative Regulation Of Anoikis Regulation Of Signaling Regulation Of Anoikis Positive Regulation Of Intracellular Transport Positive Regulation Of Signal Transduction Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Immune System Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Localization Regulation Of Neuron Death Cellular Response To Stimulus Regulation Of Establishment Of Protein Localization Response To Stimulus Response To Organic Substance Response To Cytokine Melanin Metabolic Process Positive Regulation Of Transport	Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Mitochondrion Organization Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endopeptidase Activity Zymogen Activation Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Negative Regulation Of Programmed Cell Death Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Peptidase Activity Negative Regulation Of Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Protein Processing Positive Regulation Of Proteolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Proteolysis Mitochondrial Membrane Organization Positive Regulation Of Organelle Organization Positive Regulation Of Protein Oligomerization Regulation Of Cellular Process Regulation Of Intracellular Transport Mitochondrion Organization
Tagcloud ?		70z bcgf begin bpa call chromatographic die discrete etc glycoproteins glycosylated hcgf helper heterogeneously ig implying lymphokine lymphokines mcgf mildly permeation psf purifies purify splenic supernatants synthesize variously wehi	aacr antiapoptotic antiestrogens aromatase competitive deprivation drives escaped estrogen eventually fulvestrant hcc1428 junb kinome letrozole lted mcf7 ovariectomized parental pharmacologic plk1 polo potently recur res rnai top volasertib xl
Tagcloud (Difference) ?		70z bcgf begin bpa call chromatographic die discrete etc glycoproteins glycosylated hcgf helper heterogeneously ig implying lymphokine lymphokines mcgf mildly permeation psf purifies purify splenic supernatants synthesize variously wehi	aacr antiapoptotic antiestrogens aromatase competitive deprivation drives escaped estrogen eventually fulvestrant hcc1428 junb kinome letrozole lted mcf7 ovariectomized parental pharmacologic plk1 polo potently recur res rnai top volasertib xl
Tagcloud (Intersection) ?