MUC1 and ZAP70

Number of citations of the paper that reports this interaction (PMID 14766232)
11

Data Source:
HPRD (in vitro)

		MUC1	ZAP70
Gene Name		mucin 1, cell surface associated	zeta-chain (TCR) associated protein kinase 70kDa
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Extracellular Space Cytoplasm Golgi Lumen Integral Component Of Plasma Membrane Cell Surface Apical Plasma Membrane Vesicle Extracellular Vesicular Exosome	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding P53 Binding Transcription Cofactor Activity Protein Binding	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding
	Biological Process	Protein O-linked Glycosylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Transcription By Competitive Promoter Binding O-glycan Processing Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Peptidyl-tyrosine Phosphorylation T Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration
Pathways		Post-translational protein modification Termination of O-glycan biosynthesis O-linked glycosylation of mucins O-linked glycosylation	TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Adaptive Immune System
Drugs			Staurosporine
Diseases
GWAS		Crohn's disease ( 21102463) Magnesium levels ( 20700443)
Protein-Protein Interactions		29 interactors: ABL1 APC CTNNB1 CTNND1 EGFR ERBB2 ERBB3 ERBB4 ESR1 GALNT1 GALNT10 GALNT12 GALNT15 GALNT2 GALNT4 GRB2 GSK3B JUP LCK LYN NUP62 OSGEP PPARG PRKCD SIGLEC1 SOS1 SRC TP53 ZAP70	58 interactors: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DBNL DEF6 DUSP3 EGFR ERBB3 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 LAT LAX1 LCK LCP2 MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP VAV1 WIPF1
Entrez ID		4582	7535
HPRD ID		01152	01495
Ensembl ID		ENSG00000185499	ENSG00000115085
Uniprot IDs		A5YRU5 A5YRU7 A5YRU8 A5YRV0 A5YRV2 A6ZID6 A6ZID7 A6ZIE0 A6ZIE2 A6ZIE4 A6ZIE5 A6ZIE6 A6ZIF0 B1AVQ5 B1AVQ7 B6ECB3 P15941 Q7Z538 Q7Z549 Q7Z551	P43403
PDB IDs		1SM3 2ACM 2FO4	1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Signaling Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Neurotrophin Signaling Pathway Regulation Of Cell Death Cellular Response To Organic Substance Immune Response Regulation Of Immune System Process Negative Regulation Of Signal Transduction Regulation Of Immune Response Defense Response Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Negative Regulation Of Signaling Regulation Of Cell Proliferation Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Immune System Process Regulation Of MAPK Cascade Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Cell Migration Fc-epsilon Receptor Signaling Pathway Cell Activation Single Organismal Cell-cell Adhesion Cell Motility Peptidyl-amino Acid Modification Regulation Of Phosphorus Metabolic Process O-glycan Processing Response To Organic Substance Positive Regulation Of Protein Metabolic Process Locomotion	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Cell Activation Positive Regulation Of Immune System Process Innate Immune Response Immune Response Positive Regulation Of Immune Response Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Cell Activation Defense Response Fc Receptor Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Regulation Of Signaling Regulation Of T Cell Activation Cell Communication Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Response To Stimulus Leukocyte Activation T Cell Receptor Signaling Pathway Intracellular Signal Transduction Lymphocyte Activation Platelet Activation Blood Coagulation Regulation Of Intracellular Signal Transduction Hemostasis T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Homotypic Cell-cell Adhesion Response To Stress Wound Healing Single Organismal Cell-cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation
Tagcloud ?		antigens apomucin basal carbohydrate carcinomas eyelid galnac gland glycoprotein granuloma immunohistochemically keratosis mucin neuac nevus organs papilloma pseudotumors rarely sebaceous seborrheic ser sialosyl squamous stn thr tn verruca vulgaris	cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta
Tagcloud (Difference) ?		antigens apomucin basal carbohydrate carcinomas eyelid galnac gland glycoprotein granuloma immunohistochemically keratosis mucin neuac nevus organs papilloma pseudotumors rarely sebaceous seborrheic ser sialosyl squamous stn thr tn verruca vulgaris	cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta
Tagcloud (Intersection) ?