MUC1 and RPS24

Data Source: HiPPIP (Novel)

		MUC1	RPS24
Name		mucin 1, cell surface associated	ribosomal protein S24
Structure
GO Annotations	Cellular Component	Chromatin Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Lumen Plasma Membrane Membrane Apical Plasma Membrane Vesicle Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding P53 Binding Transcription Coregulator Activity Protein Binding	RNA Binding Structural Constituent Of Ribosome Translation Initiation Factor Binding
	Biological Process	Negative Regulation Of Transcription By Competitive Promoter Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Cytoplasmic Translation RRNA Processing Translation Erythrocyte Homeostasis Ribosomal Small Subunit Biogenesis
Pathways		Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family Interleukin-4 and Interleukin-13 signaling O-linked glycosylation of mucins Termination of O-glycan biosynthesis Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		TG4010	None
Diseases		None	Diamond-Blackfan anemia (DBA)
GWAS		Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease ( 21102463 28067908 ) Estimated glomerular filtration rate ( 31015462 ) Gastric adenocarcinoma (histologically verified) ( 26098866 ) Gastric cancer ( 26098866 26129866 31383772 ) Gout ( 31578528 ) Inflammatory bowel disease ( 28067908 ) Magnesium levels ( 26058915 25886283 20700443 ) Non-cardia gastric cancer ( 26701879 ) Serum magnesium levels ( 29093028 ) Serum uric acid levels ( 30993211 29403010 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Urinary albumin-to-creatinine ratio ( 26631737 ) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737 )	California verbal learning test score ( 31596458 ) Diverticular disease ( 30177863 ) Metabolite levels ( 23823483 )
Novel Interactors		12 novel interactors: ADGRL2 E2F2 GALE IKBKE LTB4R2 OAZ1 PKLR PSMB4 RFX5 RPS24 SYT13 TFB2M	2 novel interactors: MUC1 PCDHA9
Interacting Genes		143 interacting genes: ABL1 ADAM33 ADGRB3 ADIPOQ ANKRD46 APC APOA2 APP AQP1 AQP2 AQP3 ARV1 ATM BCL2L2 BMI1 BRICD5 BTN2A2 C14orf180 C1GALT1 C2 C2CD2L C3orf52 CACNG1 CCDC167 CD47 CD53 CD68 CLDN19 CLDN6 CLDND2 CMTM7 COL8A2 CSGALNACT2 CTNNB1 CTNND1 CTSA CXCL16 CXCL9 CYB5B CYP4F2 EDDM3B EGFR EMC6 EMP3 ENTPD3 ERBB2 ERBB3 ERBB4 ERG28 ESR1 EZH2 GALNT1 GALNT10 GALNT12 GALNT15 GALNT2 GALNT4 GAST GDNF GOLT1B GPR108 GRB2 GSK3B H2AX HHATL HSP90AA1 HSPA4 ICMT INSIG2 ITGAM JUP LCK LPAR3 LYN MAL2 MALL MARCHF2 MIP MYADM NDUFA3 NEU1 NINJ1 NINJ2 NKG7 NUP62 OR10AG1 OSGEP PAQR6 PLN PLP1 PLP2 PLPP6 PNLIPRP1 PPARG PPIF PRKCD RFT1 RHD RTP2 SCAMP5 SEC22B SELENOK SERP2 SFTPC SIGLEC1 SLC22A1 SLC30A8 SLC35B4 SLC35E4 SLC38A7 SLC61A1 SMCO4 SMIM1 SOS1 SRC TECR THBD TM6SF2 TMEM11 TMEM120B TMEM121 TMEM128 TMEM147 TMEM14A TMEM14C TMEM187 TMEM218 TMEM229B TMEM243 TMEM86A TMEM86B TMEM97 TMEM98 TNFRSF10B TP53 TRAM1L1 TWIST1 UNC50 VAMP5 VKORC1 YIPF6 ZAP70 ZDHHC21	9 interacting genes: CBR1 DUX4 ERCC6 OGT PAH PCBD1 PNISR STK17B TAF9
Entrez ID		4582	6229
HPRD ID		01152	03877
Ensembl ID		ENSG00000185499	ENSG00000138326
Uniprot IDs		A0A087X0L2 A0A0A0MRB3 A0A0C4DGW3 A0A384NPK6 A5YRU5 A5YRU7 A5YRV0 A5YRV2 A6ZID6 A6ZID7 A6ZIE4 A6ZIE6 B6ECB3 P15941 Q7Z538 Q7Z551	A0A2R8Y849 P62847
PDB IDs		1SM3 2ACM 2FO4 5T6P 5T78 6FZQ 6FZR 6KX1 6TGG 7Q4I 7V4W 7V64 7V7K 7V8Q 7VAC 7VAZ 8AXH 8P6I	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6MTD 6MTE 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7QVP 7R4X 7TQL 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
GO Terms Enriched among Interactors		Membrane Polypeptide N-acetylgalactosaminyltransferase Activity Epidermal Growth Factor Receptor Signaling Pathway Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane ERBB Signaling Pathway Ephrin Receptor Binding Protein Tyrosine Kinase Activity Regulation Of Transport Positive Regulation Of Protein Localization Protein O-linked Glycosylation Via N-acetyl-galactosamine Leukocyte Activation Cellular Response To Oxygen-containing Compound Golgi Membrane Positive Regulation Of Transport ERBB2 Signaling Pathway Glial Cell Development Non-membrane Spanning Protein Tyrosine Kinase Activity Cell-cell Junction Response To Lipid Protein Binding Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Cell Migration Water Channel Activity Peptidyl-tyrosine Phosphorylation Cell Activation Apoptotic Signaling Pathway Regulation Of Protein Localization Protein O-linked Glycosylation Protein Tyrosine Kinase Activator Activity Fc Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Fc-gamma Receptor Signaling Pathway Basolateral Plasma Membrane Regulation Of Cell-cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Perinuclear Region Of Cytoplasm Regulation Of Fibroblast Proliferation Lymphocyte Activation Regulation Of Multicellular Organismal Process Golgi Apparatus Regulation Of Cell Activation Renal Water Homeostasis Schwann Cell Development Positive Regulation Of Protein Localization To Centrosome Glycerol Transmembrane Transport Protein Phosphatase Binding Myelination	Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Tyrosine Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Aromatic Amino Acid Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Carboxylic Acid Biosynthetic Process Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Negative Regulation Of Cell Cycle Process Positive Regulation Of Transcription By RNA Polymerase II Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Amino Acid Biosynthetic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II P53 Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity S-nitrosoglutathione Reductase (NADPH) Activity Negative Regulation Of Cell Cycle Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process DNA Damage Checkpoint Signaling Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Small Molecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process