MUC1 and SIGLEC1

Number of citations of the paper that reports this interaction (PMID 10610356)
23

Data Source:
HPRD (in vivo)

		MUC1	SIGLEC1
Gene Name		mucin 1, cell surface associated	sialic acid binding Ig-like lectin 1, sialoadhesin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Extracellular Space Cytoplasm Golgi Lumen Integral Component Of Plasma Membrane Cell Surface Apical Plasma Membrane Vesicle Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding P53 Binding Transcription Cofactor Activity Protein Binding	Carbohydrate Binding
	Biological Process	Protein O-linked Glycosylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Transcription By Competitive Promoter Binding O-glycan Processing Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Endocytosis Inflammatory Response Cell-matrix Adhesion Single Organismal Cell-cell Adhesion Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Post-translational protein modification Termination of O-glycan biosynthesis O-linked glycosylation of mucins O-linked glycosylation
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Magnesium levels ( 20700443)
Protein-Protein Interactions		29 interactors: ABL1 APC CTNNB1 CTNND1 EGFR ERBB2 ERBB3 ERBB4 ESR1 GALNT1 GALNT10 GALNT12 GALNT15 GALNT2 GALNT4 GRB2 GSK3B JUP LCK LYN NUP62 OSGEP PPARG PRKCD SIGLEC1 SOS1 SRC TP53 ZAP70	3 interactors: MUC1 SPN TNR
Entrez ID		4582	6614
HPRD ID		01152	02854
Ensembl ID		ENSG00000185499	ENSG00000088827
Uniprot IDs		A5YRU5 A5YRU7 A5YRU8 A5YRV0 A5YRV2 A6ZID6 A6ZID7 A6ZIE0 A6ZIE2 A6ZIE4 A6ZIE5 A6ZIE6 A6ZIF0 B1AVQ5 B1AVQ7 B6ECB3 P15941 Q7Z538 Q7Z549 Q7Z551	Q9BZZ2
PDB IDs		1SM3 2ACM 2FO4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Signaling Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Neurotrophin Signaling Pathway Regulation Of Cell Death Cellular Response To Organic Substance Immune Response Regulation Of Immune System Process Negative Regulation Of Signal Transduction Regulation Of Immune Response Defense Response Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Negative Regulation Of Signaling Regulation Of Cell Proliferation Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Immune System Process Regulation Of MAPK Cascade Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Cell Migration Fc-epsilon Receptor Signaling Pathway Cell Activation Single Organismal Cell-cell Adhesion Cell Motility Peptidyl-amino Acid Modification Regulation Of Phosphorus Metabolic Process O-glycan Processing Response To Organic Substance Positive Regulation Of Protein Metabolic Process Locomotion	Associative Learning Negative Regulation Of Cell-cell Adhesion Learning Negative Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Cell Adhesion Negative Regulation Of Type IV Hypersensitivity Learning Or Memory Cognition Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Cell-cell Adhesion Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Axon Regeneration Positive Regulation Of Transmission Of Nerve Impulse Single-organism Behavior Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Transmission Of Nerve Impulse Locomotory Exploration Behavior Single Organismal Cell-cell Adhesion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Thymic T Cell Selection Negative Regulation Of Acute Inflammatory Response Negative Regulation Of T Cell Mediated Immunity Negative T Cell Selection Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Behavior Chemotaxis Neuron Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of Histone H4 Acetylation Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Axon Regeneration Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Histone Acetylation Thymic T Cell Selection Positive Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Axon Extension Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein Acetylation Response To Protozoan Exploration Behavior Cell Migration Cell Motility
Tagcloud ?		antigens apomucin basal carbohydrate carcinomas eyelid galnac gland glycoprotein granuloma immunohistochemically keratosis mucin neuac nevus organs papilloma pseudotumors rarely sebaceous seborrheic ser sialosyl squamous stn thr tn verruca vulgaris	alternative biomarker ccr1 cd14 cluster clustering clusters complication cutaneous diffuse distinguished exclusively greatly hierarchical idiopathic ifn il13ra1 immunoassay lcssc messenger monocyte mononuclear mrc1 mx1 pah pbmc pbmcs ssc supervised
Tagcloud (Difference) ?		antigens apomucin basal carbohydrate carcinomas eyelid galnac gland glycoprotein granuloma immunohistochemically keratosis mucin neuac nevus organs papilloma pseudotumors rarely sebaceous seborrheic ser sialosyl squamous stn thr tn verruca vulgaris	alternative biomarker ccr1 cd14 cluster clustering clusters complication cutaneous diffuse distinguished exclusively greatly hierarchical idiopathic ifn il13ra1 immunoassay lcssc messenger monocyte mononuclear mrc1 mx1 pah pbmc pbmcs ssc supervised
Tagcloud (Intersection) ?