MT-CO3 and HSPB2

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		MT-CO3	HSPB2
Description		cytochrome c oxidase subunit III	heat shock protein family B (small) member 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV	Nucleus Cytoplasm Cytosol
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Electron Transfer Activity	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding
	Biological Process	Mitochondrial Electron Transport, Cytochrome C To Oxygen Respiratory Chain Complex IV Assembly Aerobic Electron Transport Chain Respiratory Electron Transport Chain Cellular Respiration Proton Transmembrane Transport	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process
Pathways		Mitochondrial translation termination TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly
Drugs		Cholic Acid N-Formylmethionine
Diseases		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS			Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: HSPB2 KRAS LIG4 RAC1 SNCA	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		4514	3316
HPRD ID		02471	03712
Ensembl ID		ENSG00000198938	ENSG00000170276
Uniprot IDs		P00414 Q7GIM7	A8KAH6 Q16082
PDB IDs		5Z62	6F2R
Enriched GO Terms of Interacting Partners?		Regulation Of Neuronal Synaptic Plasticity Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of Synaptic Plasticity Rac Protein Signal Transduction Regulation Of Neuron Apoptotic Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Vesicle Recycling Negative Regulation Of Programmed Cell Death Homeostasis Of Number Of Cells Within A Tissue Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Stress Enzyme Activator Activity G Protein Activity Positive Regulation Of Small GTPase Mediated Signal Transduction Modulation Of Chemical Synaptic Transmission Establishment Of Integrated Proviral Latency Positive Regulation Of Organelle Organization Regulation Of Microtubule Polymerization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Microtubule Polymerization Or Depolymerization Establishment Of Viral Latency Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Synaptic Vesicle Membrane Regulation Of Reactive Oxygen Species Metabolic Process Somatic Muscle Development Anatomical Structure Homeostasis Tissue Homeostasis Response To Isolation Stress Regulation Of Cell Development Response To Lipid GMP Binding Forebrain Astrocyte Development Homeostasis Of Number Of Cells DNA Ligase (ATP) Activity	Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding
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