MT-CO3

Description		cytochrome c oxidase subunit III
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Electron Transfer Activity
	Biological Process	Mitochondrial Electron Transport, Cytochrome C To Oxygen Respiratory Chain Complex IV Assembly Aerobic Electron Transport Chain Respiratory Electron Transport Chain Cellular Respiration Proton Transmembrane Transport
Pathways		Mitochondrial translation termination TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly
Drugs		Cholic Acid N-Formylmethionine
Diseases		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS
Interacting Genes		5 interacting genes: HSPB2 KRAS LIG4 RAC1 SNCA
Entrez ID		4514
HPRD ID		02471
Ensembl ID		ENSG00000198938
Uniprot IDs		P00414 Q7GIM7
PDB IDs		5Z62
Enriched GO Terms of Interacting Partners?		Regulation Of Neuronal Synaptic Plasticity Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of Synaptic Plasticity Rac Protein Signal Transduction Regulation Of Neuron Apoptotic Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Vesicle Recycling Negative Regulation Of Programmed Cell Death Homeostasis Of Number Of Cells Within A Tissue Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Stress Enzyme Activator Activity G Protein Activity Positive Regulation Of Small GTPase Mediated Signal Transduction Modulation Of Chemical Synaptic Transmission Establishment Of Integrated Proviral Latency Positive Regulation Of Organelle Organization Regulation Of Microtubule Polymerization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Microtubule Polymerization Or Depolymerization Establishment Of Viral Latency Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Synaptic Vesicle Membrane Regulation Of Reactive Oxygen Species Metabolic Process Somatic Muscle Development Anatomical Structure Homeostasis Tissue Homeostasis Response To Isolation Stress Regulation Of Cell Development Response To Lipid GMP Binding Forebrain Astrocyte Development Homeostasis Of Number Of Cells DNA Ligase (ATP) Activity
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