MMP16 and LRP1

Number of citations of the paper that reports this interaction (PMID 14645246)
21

Data Source:
HPRD (in vitro)

		MMP16	LRP1
Gene Name		matrix metallopeptidase 16 (membrane-inserted)	low density lipoprotein receptor-related protein 1
Image
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex
	Molecular Function	Metalloendopeptidase Activity Calcium Ion Binding Enzyme Activator Activity Zinc Ion Binding	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding
	Biological Process	Endochondral Ossification Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Chondrocyte Proliferation Positive Regulation Of Catalytic Activity Embryonic Cranial Skeleton Morphogenesis Craniofacial Suture Morphogenesis	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport
Drugs		Marimastat Batimastat
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index and cholesterol (psychopharmacological treatment) ( 22417934) Schizophrenia ( 21926974 22688191)	Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)
Protein-Protein Interactions		2 interactors: KISS1 LRP1	63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A
Entrez ID		4325	4035
HPRD ID		03776	00138
Ensembl ID			ENSG00000123384
Uniprot IDs		P51512	Q07954 Q59FG2
PDB IDs		1RM8	1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Phospholipase A2 Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cholesterol Efflux Positive Regulation Of Cholesterol Transport Lipoprotein Transport Regulation Of Cholesterol Efflux Aorta Morphogenesis Aorta Development Apoptotic Cell Clearance Regulation Of Cholesterol Transport Regulation Of Smooth Muscle Cell Migration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Artery Morphogenesis Positive Regulation Of Lipid Transport Artery Development Phototransduction, Visible Light Retinoid Metabolic Process Regulation Of Phospholipase Activity Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Sterol Metabolic Process Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Migration	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell
Tagcloud ?		ameliorate begin ccl2 ccl20 ccl28 ccl3 ccl4 ccl8 cd40lg cd47 cxcl1 cxcl12 cxcl13 gdf10 gdf3 il17f il1f10 il1f5 metalloproteinase mmp13 mmp7 mmps phosflow polymeric polyvinyl pvc tgfbeta3 tnfsf10	aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis
Tagcloud (Difference) ?		ameliorate begin ccl2 ccl20 ccl28 ccl3 ccl4 ccl8 cd40lg cd47 cxcl1 cxcl12 cxcl13 gdf10 gdf3 il17f il1f10 il1f5 metalloproteinase mmp13 mmp7 mmps phosflow polymeric polyvinyl pvc tgfbeta3 tnfsf10	aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis
Tagcloud (Intersection) ?