MMP16 and KISS1

Number of citations of the paper that reports this interaction (PMID 12879005)
19

Data Source:
HPRD (in vitro, in vivo)

		MMP16	KISS1
Gene Name		matrix metallopeptidase 16 (membrane-inserted)	KiSS-1 metastasis-suppressor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Extracellular Region
	Molecular Function	Metalloendopeptidase Activity Calcium Ion Binding Enzyme Activator Activity Zinc Ion Binding	Protein Binding
	Biological Process	Endochondral Ossification Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Chondrocyte Proliferation Positive Regulation Of Catalytic Activity Embryonic Cranial Skeleton Morphogenesis Craniofacial Suture Morphogenesis	Cytoskeleton Organization
Pathways		Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Marimastat Batimastat
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index and cholesterol (psychopharmacological treatment) ( 22417934) Schizophrenia ( 21926974 22688191)
Protein-Protein Interactions		2 interactors: KISS1 LRP1	7 interactors: APP KISS1R MMP14 MMP16 MMP2 MMP24 MMP9
Entrez ID		4325	3814
HPRD ID		03776	04475
Ensembl ID			ENSG00000170498
Uniprot IDs		P51512	Q15726
PDB IDs		1RM8
Enriched GO Terms of Interacting Partners?		Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Phospholipase A2 Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cholesterol Efflux Positive Regulation Of Cholesterol Transport Lipoprotein Transport Regulation Of Cholesterol Efflux Aorta Morphogenesis Aorta Development Apoptotic Cell Clearance Regulation Of Cholesterol Transport Regulation Of Smooth Muscle Cell Migration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Artery Morphogenesis Positive Regulation Of Lipid Transport Artery Development Phototransduction, Visible Light Retinoid Metabolic Process Regulation Of Phospholipase Activity Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Sterol Metabolic Process Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Migration	Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Endoderm Formation Ossification Endoderm Development Chondrocyte Proliferation Formation Of Primary Germ Layer Craniofacial Suture Morphogenesis Skeletal System Development Gastrulation Embryonic Morphogenesis Proteolysis Positive Regulation Of Catalytic Activity Neurogenesis Response To External Stimulus Skeletal System Morphogenesis Endochondral Ossification Response To Abiotic Stimulus Axon Guidance Nervous System Development Embryonic Cranial Skeleton Morphogenesis Embryo Development System Development Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Embryo Implantation Locomotion Endochondral Bone Morphogenesis Reproductive Process Ephrin Receptor Signaling Pathway Axonogenesis Multicellular Organismal Development Axon Development Anatomical Structure Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Organ Development Bone Morphogenesis Synaptic Growth At Neuromuscular Junction Embryonic Skeletal System Morphogenesis Neuron Projection Morphogenesis Regulation Of Protein Binding Positive Regulation Of Peptidase Activity
Tagcloud ?		ameliorate begin ccl2 ccl20 ccl28 ccl3 ccl4 ccl8 cd40lg cd47 cxcl1 cxcl12 cxcl13 gdf10 gdf3 il17f il1f10 il1f5 metalloproteinase mmp13 mmp7 mmps phosflow polymeric polyvinyl pvc tgfbeta3 tnfsf10	ahead alleles beyond compelling critically decade discusses embryo fertility follicular hypothalamic implantation implicating kisspeptin lie mammals manipulated neuroendocrine oocyte ovulation placentation playing powerful reproductive researchers steroid strides tremendous
Tagcloud (Difference) ?		ameliorate begin ccl2 ccl20 ccl28 ccl3 ccl4 ccl8 cd40lg cd47 cxcl1 cxcl12 cxcl13 gdf10 gdf3 il17f il1f10 il1f5 metalloproteinase mmp13 mmp7 mmps phosflow polymeric polyvinyl pvc tgfbeta3 tnfsf10	ahead alleles beyond compelling critically decade discusses embryo fertility follicular hypothalamic implantation implicating kisspeptin lie mammals manipulated neuroendocrine oocyte ovulation placentation playing powerful reproductive researchers steroid strides tremendous
Tagcloud (Intersection) ?