MMP16

Gene Name		matrix metallopeptidase 16 (membrane-inserted)
Image
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Metalloendopeptidase Activity Calcium Ion Binding Enzyme Activator Activity Zinc Ion Binding
	Biological Process	Endochondral Ossification Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Chondrocyte Proliferation Positive Regulation Of Catalytic Activity Embryonic Cranial Skeleton Morphogenesis Craniofacial Suture Morphogenesis
Pathways		Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs		Marimastat Batimastat
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index and cholesterol (psychopharmacological treatment) ( 22417934) Schizophrenia ( 21926974 22688191)
Protein-protein Interactions		2 interactors: KISS1 LRP1
Entrez ID		4325
HPRD ID		03776
Ensembl ID
Uniprot IDs		P51512
PDB IDs		1RM8
Enriched GO Terms of Interacting Partners?		Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Phospholipase A2 Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cholesterol Efflux Positive Regulation Of Cholesterol Transport Lipoprotein Transport Regulation Of Cholesterol Efflux Aorta Morphogenesis Aorta Development Apoptotic Cell Clearance Regulation Of Cholesterol Transport Regulation Of Smooth Muscle Cell Migration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Artery Morphogenesis Positive Regulation Of Lipid Transport Artery Development Phototransduction, Visible Light Retinoid Metabolic Process Regulation Of Phospholipase Activity Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Sterol Metabolic Process Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Migration
Tagcloud ?		ameliorate begin ccl2 ccl20 ccl28 ccl3 ccl4 ccl8 cd40lg cd47 cxcl1 cxcl12 cxcl13 gdf10 gdf3 il17f il1f10 il1f5 metalloproteinase mmp13 mmp7 mmps phosflow polymeric polyvinyl pvc tgfbeta3 tnfsf10