MBL2 and PTPRC

Number of citations of the paper that reports this interaction (PubMedID 11564800)
0

Data Source:
HPRD (in vivo, in vitro)

		MBL2	PTPRC
Description		mannose binding lectin 2	protein tyrosine phosphatase receptor type C
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Multivesicular Body External Side Of Plasma Membrane Cell Surface Symbiont Cell Surface Serine-type Endopeptidase Complex	Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Bleb Membrane Raft Synapse Extracellular Exosome Cell Periphery Side Of Membrane Membrane Microdomain
	Molecular Function	Signaling Receptor Binding Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Identical Protein Binding Calcium-dependent Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Heparin Binding Hydrolase Activity Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Ankyrin Binding Spectrin Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Proteolysis Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Zymogen Activation Killing Of Cells Of Another Organism Defense Response To Bacterium Surfactant Homeostasis Innate Immune Response Negative Regulation Of Viral Process Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Protein Maturation Killing By Host Of Symbiont Cells Antiviral Innate Immune Response Positive Regulation Of Opsonization	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Natural Killer Cell Differentiation Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Mediated Immunity Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Leukocyte Cell-cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Response To Gamma Radiation Regulation Of Gene Expression Dephosphorylation B Cell Differentiation T Cell Differentiation Positive Regulation Of B Cell Proliferation Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Gamma-delta T Cell Differentiation Positive Regulation Of MAPK Cascade Cell Cycle Phase Transition Plasma Membrane Raft Distribution Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Alpha-beta T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Stem Cell Development Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Microglial Cell Activation Response To Aldosterone DN2 Thymocyte Differentiation Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Lectin pathway of complement activation Initial triggering of complement SARS-CoV-2 activates/modulates innate and adaptive immune responses	Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation
Drugs		O3-Sulfonylgalactose Methyl alpha-D-mannoside 4-(Hydrogen sulfate)-beta-D-galactopyranose Methyl beta-L-fucopyranoside N-acetyl-alpha-neuraminic acid alpha-L-methyl-fucose Alpha-Methyl-N-Acetyl-D-Glucosamine
Diseases		Tuberculosis Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency	T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Age-related macular degeneration ( 23326517) Blood protein levels ( 30072576) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chin dimples ( 27182965) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 29499414) Fractures ( 30158200 30598549) Heel bone mineral density ( 28869591 30598549) Lumbar spine bone mineral density ( 22504420 29499414) Metabolite levels ( 23823483) Monobrow ( 27182965) Rosacea symptom severity ( 29771307)	Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 34103634 32296059 31619474 30929738) Asthma (adult onset) ( 30929738) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 28067908 26192919) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) LDL cholesterol levels ( 32203549) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 20139978 29403010 28017375) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 33272962) Type 1 diabetes ( 34012112) Ulcerative colitis ( 24837172) Vitiligo ( 27723757) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC UBQLN2	45 interacting genes: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MAPK1 MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 SRC TYK2 UHRF2 ZAP70
Entrez ID		4153	5788
HPRD ID		01107	01050
Ensembl ID		ENSG00000165471	ENSG00000081237
Uniprot IDs		P11226	M9MML4 P08575
PDB IDs		1HUP	1YGR 1YGU 5FMV 5FN6 5FN7 8VSE
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Complement Activation Complement Component C1q Complex Binding Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Activation Of Immune Response Spectrin Binding Carbohydrate Binding Positive Regulation Of Immune System Process Response To Other Organism Zymogen Activation Calcium Ion Binding Cell Surface Amylin Receptor Complex 2 Calcitonin Family Receptor Activity Positive Regulation Of Calcium-mediated Signaling Amylin Receptor Complex 1 Calcitonin Binding Response To External Biotic Stimulus Positive Regulation Of Immune Response Humoral Immune Response Regulation Of Humoral Immune Response Plasma Membrane Raft Distribution Regulation Of Endocytosis Sarcoplasmic Reticulum Protein Maturation Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Location In Cell Maintenance Of Location Maintenance Of Protein Location In Plasma Membrane Amylin Receptor Complex 3 Calcitonin Receptor Activity Positive Regulation Of Phagocytosis Regulation Of Immune System Process Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Calcium-dependent Protein Binding Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Complement Component C4b Binding Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Calcium-mediated Signaling ERAD Pathway Immune Effector Process Secretory Granule Membrane Regulation Of Phagocytosis Regulation Of Immune Response Positive Regulation Of Cell Communication By Electrical Coupling Cytoskeleton Organization Amylin Receptor 3 Signaling Pathway	Leukocyte Activation Cell Surface Receptor Signaling Pathway Lymphocyte Activation Cell Activation Regulation Of Immune Response Positive Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation T Cell Costimulation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of Lymphocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune Response Immune System Process Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Immune System Process Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Signaling Pathway Immune Response Activation Of Immune Response T Cell Activation Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway T Cell Receptor Signaling Pathway Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Protein Kinase Activity Protein Phosphorylation Regulation Of Leukocyte Proliferation Phosphorylation Immune Effector Process Signaling Receptor Binding Lymphocyte Differentiation Regulation Of Mononuclear Cell Proliferation Fc Receptor Signaling Pathway Mononuclear Cell Differentiation
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