MBL2 and PTPRC

Number of citations of the paper that reports this interaction (PMID 11564800)
9

Data Source:
HPRD (in vivo, in vitro)

		MBL2	PTPRC
Gene Name		mannose-binding lectin (protein C) 2, soluble	protein tyrosine phosphatase, receptor type, C
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Cell Surface	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Calcium Ion Binding Protein Binding Mannose Binding Calcium-dependent Protein Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process	Complement Activation, Lectin Pathway Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Defense Response To Bacterium Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Negative Regulation Of Viral Process Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Killing By Host Of Symbiont Cells	Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Immunoglobulin Biosynthetic Process Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell Surface Receptor Signaling Pathway Axon Guidance Dephosphorylation T Cell Differentiation Positive Regulation Of B Cell Proliferation Peptidyl-tyrosine Dephosphorylation B Cell Proliferation Positive Regulation Of T Cell Proliferation Cell Cycle Phase Transition Positive Regulation Of Protein Kinase Activity Bone Marrow Development Stem Cell Development T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation
Pathways		Creation of C4 and C2 activators Complement cascade Initial triggering of complement Lectin pathway of complement activation Innate Immune System	TCR signaling Axon guidance Semaphorin interactions Other semaphorin interactions Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Bone mineral density ( 22504420)	Mean corpuscular hemoglobin ( 20139978)
Protein-Protein Interactions		8 interactors: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC	43 interactors: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 TYK2 UHRF2 ZAP70
Entrez ID		4153	5788
HPRD ID		01107	01050
Ensembl ID		ENSG00000165471	ENSG00000081237
Uniprot IDs		P11226 Q5SQS3	M9MML4 P08575
PDB IDs		1HUP	1YGR 1YGU
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Positive Regulation Of Immune System Process Complement Activation Immune System Process Protein Activation Cascade Regulation Of Immune System Process Positive Regulation Of Immune Response Endocytosis Humoral Immune Response Cellular Calcium Ion Homeostasis Regulation Of Immune Response Chemical Homeostasis Calcium Ion Homeostasis Negative Regulation Of Protein Metabolic Process Regulation Of Humoral Immune Response Receptor-mediated Endocytosis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Peptide Antigen Assembly With MHC Class I Protein Complex Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Defense Response Homeostatic Process Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Ion Homeostasis Vesicle-mediated Transport Negative Regulation Of Immune Response Positive Regulation Of DNA Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Homeostasis Negative Regulation Of APC-Cdc20 Complex Activity Sequestering Of Calcium Ion Cytosolic Calcium Ion Homeostasis Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of T Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Spindle Checkpoint Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Response To Stress Glucocorticoid Receptor Signaling Pathway Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Cell Division Positive Regulation Of Gamma-delta T Cell Differentiation	Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Cell Activation Immune Response Immune System Process Defense Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Innate Immune Response Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Activation Leukocyte Activation Regulation Of Lymphocyte Activation T Cell Costimulation Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Homotypic Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Aggregation Locomotion Lymphocyte Activation Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Response To Stress Immune Response-regulating Signaling Pathway Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Cell Adhesion Signaling Response To Stimulus Regulation Of Signal Transduction Cell Communication T Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		32p alkali arises cytoskeletal detergent distinctive encode enzymatic heavily incubation insoluble labelled lstra membranous mo moloney momulv mulv murine phosphoproteins phosphorylate pp60src reflecting sarcoma shares transformed transforming view viruses	abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv
Tagcloud (Difference) ?		32p alkali arises cytoskeletal detergent distinctive encode enzymatic heavily incubation insoluble labelled lstra membranous mo moloney momulv mulv murine phosphoproteins phosphorylate pp60src reflecting sarcoma shares transformed transforming view viruses	abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv
Tagcloud (Intersection) ?