MBL2 and CALCR

Number of citations of the paper that reports this interaction (PubMedID 11560994)
130

Data Source:
HPRD (in vivo)

		MBL2	CALCR
Description		mannose binding lectin 2	calcitonin receptor
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Multivesicular Body External Side Of Plasma Membrane Cell Surface Symbiont Cell Surface Serine-type Endopeptidase Complex	Acrosomal Vesicle Plasma Membrane Cilium Membrane Axon Amylin Receptor Complex 1 Amylin Receptor Complex 2 Amylin Receptor Complex 3
	Molecular Function	Signaling Receptor Binding Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Identical Protein Binding Calcium-dependent Protein Binding	Amyloid-beta Binding Calcitonin Gene-related Peptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Calcitonin Binding Calcitonin Family Receptor Activity Amylin Receptor Activity
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Proteolysis Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Zymogen Activation Killing Of Cells Of Another Organism Defense Response To Bacterium Surfactant Homeostasis Innate Immune Response Negative Regulation Of Viral Process Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Protein Maturation Killing By Host Of Symbiont Cells Antiviral Innate Immune Response Positive Regulation Of Opsonization	Ossification Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Gene Expression Negative Regulation Of Ossification Osteoclast Differentiation Regulation Of MRNA Stability Positive Regulation Of Calcium-mediated Signaling Response To Glucocorticoid Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Calcitonin Family Receptor Signaling Pathway Amylin Receptor Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Amylin Receptor 3 Signaling Pathway Response To Amyloid-beta Calcitonin Gene-related Peptide Receptor Signaling Pathway
Pathways		Lectin pathway of complement activation Initial triggering of complement SARS-CoV-2 activates/modulates innate and adaptive immune responses	G alpha (s) signalling events Calcitonin-like ligand receptors
Drugs		O3-Sulfonylgalactose Methyl alpha-D-mannoside 4-(Hydrogen sulfate)-beta-D-galactopyranose Methyl beta-L-fucopyranoside N-acetyl-alpha-neuraminic acid alpha-L-methyl-fucose Alpha-Methyl-N-Acetyl-D-Glucosamine	Salmon calcitonin Pramlintide
Diseases		Tuberculosis Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency
GWAS		Age-related macular degeneration ( 23326517) Blood protein levels ( 30072576) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chin dimples ( 27182965) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 29499414) Fractures ( 30158200 30598549) Heel bone mineral density ( 28869591 30598549) Lumbar spine bone mineral density ( 22504420 29499414) Metabolite levels ( 23823483) Monobrow ( 27182965) Rosacea symptom severity ( 29771307)	A body shape index ( 34021172) Birth weight ( 23202124) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413 25760438 28448500 28892062) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Cutaneous leishmaniasis ( 32830257) Hip circumference ( 28552196 25673412) Lean body mass ( 28552196 28724990) Type 2 diabetes ( 32499647) Weight ( 28552196)
Interacting Genes		9 interacting genes: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC UBQLN2	9 interacting genes: CALM1 FLNA GPRASP1 GPRASP2 MBL2 RAMP1 RAMP3 SQSTM1 THBS1
Entrez ID		4153	799
HPRD ID		01107	00239
Ensembl ID		ENSG00000165471	ENSG00000004948
Uniprot IDs		P11226	A0A0A0MSQ7 P30988
PDB IDs		1HUP	5II0 5UZ7 6NIY 6PFO 6PGQ 7TYF 7TYH 7TYI 7TYL 7TYN 7TYO 7TYW 7TYX 7TYY 7TZF 8F0J 8F0K 8F2A 8F2B 9AUC
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Complement Activation Complement Component C1q Complex Binding Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Activation Of Immune Response Spectrin Binding Carbohydrate Binding Positive Regulation Of Immune System Process Response To Other Organism Zymogen Activation Calcium Ion Binding Cell Surface Amylin Receptor Complex 2 Calcitonin Family Receptor Activity Positive Regulation Of Calcium-mediated Signaling Amylin Receptor Complex 1 Calcitonin Binding Response To External Biotic Stimulus Positive Regulation Of Immune Response Humoral Immune Response Regulation Of Humoral Immune Response Plasma Membrane Raft Distribution Regulation Of Endocytosis Sarcoplasmic Reticulum Protein Maturation Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Location In Cell Maintenance Of Location Maintenance Of Protein Location In Plasma Membrane Amylin Receptor Complex 3 Calcitonin Receptor Activity Positive Regulation Of Phagocytosis Regulation Of Immune System Process Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Calcium-dependent Protein Binding Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Complement Component C4b Binding Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Calcium-mediated Signaling ERAD Pathway Immune Effector Process Secretory Granule Membrane Regulation Of Phagocytosis Regulation Of Immune Response Positive Regulation Of Cell Communication By Electrical Coupling Cytoskeleton Organization Amylin Receptor 3 Signaling Pathway	Amylin Receptor Activity Amylin Receptor Signaling Pathway Calcitonin Family Receptor Signaling Pathway Protein Activation Cascade Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Vesicle-mediated Transport Protein Localization To Plasma Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Protein Localization To Cell Periphery Calcium Ion Transport Protein Sequestering Activity Cell Surface G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Sperm Midpiece Sarcomere Regulation Of Action Potential Regulation Of Signaling Establishment Of Localization In Cell Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Protein Maturation Cellular Localization Protein Localization To Membrane Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Calcitonin Gene-related Peptide Binding Coreceptor Activity Cross-receptor Inhibition Within G Protein-coupled Receptor Heterodimer Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Receptor Internalization G Protein-coupled Receptor Binding Calcium-dependent Protein Binding Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Communication Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Signaling Regulation Of Calcium-mediated Signaling Negative Regulation Of Nitric Oxide Mediated Signal Transduction Collagen V Binding Brown Fat Cell Proliferation Amphisome Positive Regulation Of Protein Localization To Membrane G Protein-coupled Receptor Catabolic Process CGRP Receptor Complex Amyloid-beta Binding Amylin Receptor Complex 3 Signal Transduction Endocytosis
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