MBL2 and CALCR

Number of citations of the paper that reports this interaction (PMID 11560994)
165

Data Source:
HPRD (in vivo)

		MBL2	CALCR
Gene Name		mannose-binding lectin (protein C) 2, soluble	calcitonin receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Cell Surface	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Binding Calcium Ion Binding Protein Binding Mannose Binding Calcium-dependent Protein Binding	Receptor Activity Calcitonin Receptor Activity Protein Binding Protein Transporter Activity Calcitonin Binding
	Biological Process	Complement Activation, Lectin Pathway Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Defense Response To Bacterium Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Negative Regulation Of Viral Process Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Killing By Host Of Symbiont Cells	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Positive Regulation Of Adenylate Cyclase Activity Response To Glucocorticoid Protein Localization To Plasma Membrane
Pathways		Creation of C4 and C2 activators Complement cascade Initial triggering of complement Lectin pathway of complement activation Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Salmon Calcitonin Pramlintide
Diseases
GWAS		Age-related macular degeneration ( 23326517) Bone mineral density ( 22504420)	Birth weight ( 23202124)
Protein-Protein Interactions		8 interactors: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC	8 interactors: CALM1 FLNA GPRASP1 GPRASP2 MBL2 RAMP1 RAMP3 THBS1
Entrez ID		4153	799
HPRD ID		01107	00239
Ensembl ID		ENSG00000165471	ENSG00000004948
Uniprot IDs		P11226 Q5SQS3	A4D1G6 P30988
PDB IDs		1HUP
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Positive Regulation Of Immune System Process Complement Activation Immune System Process Protein Activation Cascade Regulation Of Immune System Process Positive Regulation Of Immune Response Endocytosis Humoral Immune Response Cellular Calcium Ion Homeostasis Regulation Of Immune Response Chemical Homeostasis Calcium Ion Homeostasis Negative Regulation Of Protein Metabolic Process Regulation Of Humoral Immune Response Receptor-mediated Endocytosis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Peptide Antigen Assembly With MHC Class I Protein Complex Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Defense Response Homeostatic Process Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Ion Homeostasis Vesicle-mediated Transport Negative Regulation Of Immune Response Positive Regulation Of DNA Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Homeostasis Negative Regulation Of APC-Cdc20 Complex Activity Sequestering Of Calcium Ion Cytosolic Calcium Ion Homeostasis Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of T Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Spindle Checkpoint Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Response To Stress Glucocorticoid Receptor Signaling Pathway Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Cell Division Positive Regulation Of Gamma-delta T Cell Differentiation	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Vesicle-mediated Transport Platelet Degranulation Membrane Organization Receptor Metabolic Process Establishment Of Localization In Cell Cellular Localization Regulation Of Signal Transduction Platelet Activation Transport Endocytosis Regulation Of Signaling Receptor Internalization Negative Regulation Of Ion Transmembrane Transport Exocytosis Negative Regulation Of Transmembrane Transport Protein Localization To Membrane Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Transport Positive Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Steroid Hormone Regulation Of CAMP Biosynthetic Process Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Secretion By Cell Negative Regulation Of Ion Transport Regulation Of CAMP Metabolic Process Regulation Of Body Fluid Levels Response To Calcium Ion Intracellular Transport Wound Healing G-protein Coupled Receptor Catabolic Process Secretion Cell Activation Response To Wounding Protein Localization To Plasma Membrane Engulfment Of Apoptotic Cell Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Transport Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Protein Glycosylation G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Antigen Processing And Presentation
Tagcloud ?		32p alkali arises cytoskeletal detergent distinctive encode enzymatic heavily incubation insoluble labelled lstra membranous mo moloney momulv mulv murine phosphoproteins phosphorylate pp60src reflecting sarcoma shares transformed transforming view viruses	acp5 b220 calcitonin cd11b cd2 cd31 cd3e cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11
Tagcloud (Difference) ?		32p alkali arises cytoskeletal detergent distinctive encode enzymatic heavily incubation insoluble labelled lstra membranous mo moloney momulv mulv murine phosphoproteins phosphorylate pp60src reflecting sarcoma shares transformed transforming view viruses	acp5 b220 calcitonin cd11b cd2 cd31 cd3e cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11
Tagcloud (Intersection) ?