MBL2 and CD93

Number of citations of the paper that reports this interaction (PubMedID 9476117)
0

Data Source:
HPRD (in vitro)

		MBL2	CD93
Description		mannose binding lectin 2	CD93 molecule
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Multivesicular Body External Side Of Plasma Membrane Cell Surface Symbiont Cell Surface Serine-type Endopeptidase Complex	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Cytoplasmic Vesicle Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Identical Protein Binding Calcium-dependent Protein Binding	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Proteolysis Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Zymogen Activation Killing Of Cells Of Another Organism Defense Response To Bacterium Surfactant Homeostasis Innate Immune Response Negative Regulation Of Viral Process Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Protein Maturation Killing By Host Of Symbiont Cells Antiviral Innate Immune Response Positive Regulation Of Opsonization	Angiogenesis Phagocytosis Cell Adhesion Macrophage Activation Cell-cell Adhesion
Pathways		Lectin pathway of complement activation Initial triggering of complement SARS-CoV-2 activates/modulates innate and adaptive immune responses	Neutrophil degranulation
Drugs		O3-Sulfonylgalactose Methyl alpha-D-mannoside 4-(Hydrogen sulfate)-beta-D-galactopyranose Methyl beta-L-fucopyranoside N-acetyl-alpha-neuraminic acid alpha-L-methyl-fucose Alpha-Methyl-N-Acetyl-D-Glucosamine
Diseases		Tuberculosis Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency
GWAS		Age-related macular degeneration ( 23326517) Blood protein levels ( 30072576) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chin dimples ( 27182965) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 29499414) Fractures ( 30158200 30598549) Heel bone mineral density ( 28869591 30598549) Lumbar spine bone mineral density ( 22504420 29499414) Metabolite levels ( 23823483) Monobrow ( 27182965) Rosacea symptom severity ( 29771307)	Liver enzyme levels (alanine transaminase) ( 24124411) Obesity-related traits ( 23251661) Venous thromboembolism ( 26888256 31676865)
Interacting Genes		9 interacting genes: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC UBQLN2	25 interacting genes: ARHGAP15 BAG6 C1QA COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COPS5 F12 GIPC1 ITGB1 KIR2DL2 KNG1 MBL2 MMRN2 MSN MYD88 RANBP1 SCYL1 TENT5A UBQLN2
Entrez ID		4153	22918
HPRD ID		01107	00396
Ensembl ID		ENSG00000165471	ENSG00000125810
Uniprot IDs		P11226	Q9NPY3
PDB IDs		1HUP	8A59 8IVD
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Complement Activation Complement Component C1q Complex Binding Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Activation Of Immune Response Spectrin Binding Carbohydrate Binding Positive Regulation Of Immune System Process Response To Other Organism Zymogen Activation Calcium Ion Binding Cell Surface Amylin Receptor Complex 2 Calcitonin Family Receptor Activity Positive Regulation Of Calcium-mediated Signaling Amylin Receptor Complex 1 Calcitonin Binding Response To External Biotic Stimulus Positive Regulation Of Immune Response Humoral Immune Response Regulation Of Humoral Immune Response Plasma Membrane Raft Distribution Regulation Of Endocytosis Sarcoplasmic Reticulum Protein Maturation Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Location In Cell Maintenance Of Location Maintenance Of Protein Location In Plasma Membrane Amylin Receptor Complex 3 Calcitonin Receptor Activity Positive Regulation Of Phagocytosis Regulation Of Immune System Process Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Calcium-dependent Protein Binding Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Complement Component C4b Binding Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Calcium-mediated Signaling ERAD Pathway Immune Effector Process Secretory Granule Membrane Regulation Of Phagocytosis Regulation Of Immune Response Positive Regulation Of Cell Communication By Electrical Coupling Cytoskeleton Organization Amylin Receptor 3 Signaling Pathway	Collagen Trimer Collagen Type IV Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Extracellular Matrix Structural Constituent Extracellular Matrix Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Organization Extracellular Structure Organization Extracellular Region Platelet-derived Growth Factor Binding Response To Amino Acid Collagen Type I Trimer Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Amino Acid Stimulus Signal Transduction Signaling Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Fibrillar Collagen Trimer Inflammatory Response Glomerular Basement Membrane Development Molecular Adaptor Activity Skin Morphogenesis Regulation Of Proteolysis Endothelial Cell Migration Misfolded Protein Binding Positive Regulation Of ERAD Pathway Regulation Of Response To Endoplasmic Reticulum Stress Symbiont Cell Surface Protease Binding Cell Migration Involved In Sprouting Angiogenesis Regulation Of ERAD Pathway Killing Of Cells Of Another Organism Angiogenesis Cellular Response To Low-density Lipoprotein Particle Stimulus Killing By Host Of Symbiont Cells Leukocyte Activation Leukocyte Activation Involved In Inflammatory Response Complement Activation, Classical Pathway Cellular Response To Vitamin E Protein Heterotrimerization Neuromuscular Junction Development Basement Membrane Organization Regulation Of Anatomical Structure Morphogenesis Regulation Of Wound Healing Zymogen Activation Cellular Response To Lipoprotein Particle Stimulus
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