MBL2 and MASP2

Number of citations of the paper that reports this interaction (PMID 10878362)
11

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		MBL2	MASP2
Gene Name		mannose-binding lectin (protein C) 2, soluble	mannan-binding lectin serine peptidase 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Cell Surface	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Calcium Ion Binding Protein Binding Mannose Binding Calcium-dependent Protein Binding	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Calcium-dependent Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Defense Response To Bacterium Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Negative Regulation Of Viral Process Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Killing By Host Of Symbiont Cells	Complement Activation, Lectin Pathway Proteolysis Complement Activation Complement Activation, Classical Pathway Innate Immune Response
Pathways		Creation of C4 and C2 activators Complement cascade Initial triggering of complement Lectin pathway of complement activation Innate Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Bone mineral density ( 22504420)
Protein-Protein Interactions		8 interactors: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC	3 interactors: FCN2 MBL2 SERPING1
Entrez ID		4153	10747
HPRD ID		01107	05484
Ensembl ID		ENSG00000165471	ENSG00000009724
Uniprot IDs		P11226 Q5SQS3	O00187
PDB IDs		1HUP	1Q3X 1SZB 1ZJK 3TVJ 4FXG
Enriched GO Terms of Interacting Partners?		Complement Activation, Lectin Pathway Positive Regulation Of Immune System Process Complement Activation Immune System Process Protein Activation Cascade Regulation Of Immune System Process Positive Regulation Of Immune Response Endocytosis Humoral Immune Response Cellular Calcium Ion Homeostasis Regulation Of Immune Response Chemical Homeostasis Calcium Ion Homeostasis Negative Regulation Of Protein Metabolic Process Regulation Of Humoral Immune Response Receptor-mediated Endocytosis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Peptide Antigen Assembly With MHC Class I Protein Complex Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Defense Response Homeostatic Process Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Ion Homeostasis Vesicle-mediated Transport Negative Regulation Of Immune Response Positive Regulation Of DNA Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Homeostasis Negative Regulation Of APC-Cdc20 Complex Activity Sequestering Of Calcium Ion Cytosolic Calcium Ion Homeostasis Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of T Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Spindle Checkpoint Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Response To Stress Glucocorticoid Receptor Signaling Pathway Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Cell Division Positive Regulation Of Gamma-delta T Cell Differentiation	Complement Activation Complement Activation, Lectin Pathway Protein Activation Cascade Opsonization Humoral Immune Response Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Regulation Of Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Defense Response Defense Response To Bacterium Vesicle-mediated Transport Negative Regulation Of Complement Activation, Lectin Pathway Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Phagocytosis Leukocyte Mediated Immunity Adaptive Immune Response Immune System Process Recognition Of Apoptotic Cell Killing By Host Of Symbiont Cells Response To Bacterium Negative Regulation Of Complement Activation Blood Coagulation, Intrinsic Pathway Phagocytosis, Recognition Endocytosis Response To Other Organism Response To Biotic Stimulus Killing Of Cells Of Other Organism Response To Stress Negative Regulation Of Growth Of Symbiont In Host Fibrinolysis Regulation Of Complement Activation Apoptotic Cell Clearance Interaction With Symbiont Defense Response To Gram-negative Bacterium Negative Regulation Of Innate Immune Response Acute-phase Response Positive Regulation Of Phagocytosis Regulation Of Humoral Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Phagocytosis Negative Regulation Of Wound Healing
Tagcloud ?		32p alkali arises cytoskeletal detergent distinctive encode enzymatic heavily incubation insoluble labelled lstra membranous mo moloney momulv mulv murine phosphoproteins phosphorylate pp60src reflecting sarcoma shares transformed transforming view viruses	2d apoa1 apoa4 biochemistry bioinformatic cfhr1 clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur
Tagcloud (Difference) ?		32p alkali arises cytoskeletal detergent distinctive encode enzymatic heavily incubation insoluble labelled lstra membranous mo moloney momulv mulv murine phosphoproteins phosphorylate pp60src reflecting sarcoma shares transformed transforming view viruses	2d apoa1 apoa4 biochemistry bioinformatic cfhr1 clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur
Tagcloud (Intersection) ?